Piperazine phosphateProduct ingredient for Piperazine

Name
Piperazine phosphate
Drug Entry
Piperazine

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Accession Number
DBSALT001633
Structure
Synonyms
Not Available
UNII
8TIF7T48FP
CAS Number
18534-18-4
Weight
Average: 202.147
Monoisotopic: 202.071858589
Chemical Formula
C4H15N2O5P
InChI Key
PMGABIJVFLPSLS-UHFFFAOYSA-N
InChI
InChI=1S/C4H10N2.H3O4P.H2O/c1-2-6-4-3-5-1;1-5(2,3)4;/h5-6H,1-4H2;(H3,1,2,3,4);1H2
IUPAC Name
phosphoric acid piperazine hydrate
SMILES
O.OP(O)(O)=O.C1CNCCN1
KEGG Compound
C12839
ChemSpider
392013
ChEBI
32006
ChEMBL
CHEMBL2105892
Predicted Properties
PropertyValueSource
Water Solubility16.0 mg/mLALOGPS
logP-0.96ALOGPS
logP-0.73Chemaxon
logS-0.79ALOGPS
pKa (Strongest Basic)9.56Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area24.06 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity25.45 m3·mol-1Chemaxon
Polarizability9.88 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon