Peramivir hydrateProduct ingredient for Peramivir
- Name
- Peramivir hydrate
- Drug Entry
- Peramivir
Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. Being an influenza virus neuraminidase inhibitor, peramivir works by preventing new viruses from emerging from infected cells. Due to the poor oral bioavailability, the oral formulation of the drug was previously abandoned by Johnson and Johnson Company. The injectable intravenous formulation of peramivir was approved by the FDA in September 2017 for the treatment of acute uncomplicated influenza to pediatric patients 2 years and older who have been symptomatic for no more than two days.
- Accession Number
- DBSALT001847
- Structure
- Synonyms
- Peramivir / Peramivir trihydrate
- External IDs
- BCX 1812 / BCX-1812 / BCX1812
- UNII
- QW7Y7ZR15U
- CAS Number
- 1041434-82-5
- Weight
- Average: 382.458
Monoisotopic: 382.242749451 - Chemical Formula
- C15H34N4O7
- InChI Key
- RFUCJKFZFXNIGB-ZBBHRWOZSA-N
- InChI
- InChI=1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1
- IUPAC Name
- (1S,2S,3R,4R)-4-carbamimidamido-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid trihydrate
- SMILES
- O.O.O.[H][C@@]1([C@@H](NC(C)=O)C(CC)CC)[C@H](O)[C@H](C[C@H]1NC(N)=N)C(O)=O
- External Links
- ChemSpider
- 10128666
- ChEMBL
- CHEMBL3989402
- Predicted Properties
Property Value Source Water Solubility 0.38 mg/mL ALOGPS logP -0.27 ALOGPS logP -2.1 Chemaxon logS -2.9 ALOGPS pKa (Strongest Acidic) 4.09 Chemaxon pKa (Strongest Basic) 12.46 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 6 Chemaxon Polar Surface Area 148.53 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 94.46 m3·mol-1 Chemaxon Polarizability 34.98 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon