Identification
- Summary
Hydroxyethyl cellulose is an ingredient used in formulations to alleviate irritation of the skin.
- Generic Name
- Hydroxyethyl cellulose
- DrugBank Accession Number
- DB11602
- Background
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Hydroxyethyl cellulose (DB11602)
- Weight
- Average: 806.937
Monoisotopic: 806.451130034 - Chemical Formula
- C36H70O19
- Synonyms
- 2-Hydroxyethyl cellulose ether
- Cellulose hydroxyethyl ether
- Cellulose hydroxyethylate
- hydroxyethylcellulose
Pharmacology
- Indication
For alleviating surface irritation in topical ocular administrations, such as artificial tear solutions. Hydroxyethyl cellulose is also found in topical formulations to aid in more efficient drug diffusion across the membranes.
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Hydroxyethyl cellulose acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels 4.
- Mechanism of action
Interacts with the solid surface through hydrogen bonding to thicken and prolong the formation time of a water-retaining film. Hydroxyethyl cellulose acts as a drug carrier or microsphere to entrap other drug molecules and form a viscous gel-like dispersion, enabling drug diffusion across biological membranes 3.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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May cause chemical pneumonitis in case of inhalation and skin irritation. Animal data suggests potential alteration in female fertility.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
- International/Other Brands
- Cellosize (The DOW Chemical Company)
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image AOPAR Water Based Personal Lubricant Lotion 0.381 g/30mL Rectal; Vaginal Shenzhen ZhiHuiChuangXiang Technology Co., Ltd 2021-04-13 Not applicable US 
Optase Allegro Solution / drops 0.35 mg/1mL Ophthalmic Scope Health Inc 2023-03-23 Not applicable US Rohto Hydra Liquid 6 mg/1mL Ophthalmic Rohto-Mentholatum (Vietnam) Co. Ltd. 2012-03-15 2014-01-31 US Rohto Hydra Liquid 6 mg/1mL Ophthalmic Rohto Pharmaceutical Co. Ltd. 2011-01-03 2018-10-31 US Rohto Hydra Liquid 6 mg/1mL Ophthalmic The Mentholatum Company 2011-01-03 2018-10-31 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image AnubisMed Hydroxyethyl cellulose (0.34875 g/50mL) + Ammonia (2.75 g/50mL) + Ascorbyl glucoside (0.25 g/50mL) + Ethanol (6.3 mL/50mL) + Ethylhexylglycerin (0.025 g/50mL) + Glycolic acid (17 g/50mL) + Hexylresorcinol (1 g/50mL) + Isopropyl alcohol (0.75 g/50mL) + Kojic acid (2.5 g/50mL) + Lactic acid (5 g/50mL) + Phenoxyethanol (0.225 g/50mL) + Propylene glycol (0.5 g/50mL) + Salicylic acid (1 g/50mL) + Water (7.333 mL/50mL) Liquid Topical ANUBIS COSMETICS SL 2022-11-04 2027-07-01 US ExEm Foam Hydroxyethyl cellulose (5500 MPa.s at 2%) (80.97 mg/5mL) + Glycerin (434.8 mg/5mL) + Water (5 mL/5mL) Kit Intrauterine GISKIT PHARMA B.V. 2020-10-16 Not applicable US Goojin Bio Serum Hydroxyethyl cellulose (100 MPa.s at 2%) (0.5 mg/1mL) + Allantoin (0.5 mg/1mL) + Glycerin (35 mg/1mL) Liquid Topical Pharmacal International Co.,Ltd. 2018-06-07 Not applicable US Gujin Bio Serum Hydroxyethyl cellulose (100 MPa.s at 2%) (0.5 mg/1mL) + Allantoin (0.5 mg/1mL) + Glycerin (35 mg/1mL) Liquid Topical Pharmacal International Co.,Ltd. 2018-06-07 Not applicable US Inner Cell Serum- Serum Hydroxyethyl cellulose (100 MPa.s at 2%) (0.5 mg/1mL) + Allantoin (0.5 mg/1mL) + Glycerin (35 mg/1mL) Emulsion Topical Pharmacal International Co.,Ltd. 2018-08-07 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image AOPAR Water Based Personal Lubricant Hydroxyethyl cellulose (140 MPa.s at 5%) (0.381 g/30mL) Lotion Rectal; Vaginal Shenzhen ZhiHuiChuangXiang Technology Co., Ltd 2021-04-13 Not applicable US Jenacell Supercell Serum Hydroxyethyl cellulose (100 MPa.s at 2%) (0.018 g/2mL) + Allantoin (0.006 g/2mL) + Glycerin (0.14 g/2mL) Liquid Topical Functionfive Inc. 2017-03-01 2019-11-01 US UTIMI Water Based Personal Lubricant Hydroxyethyl cellulose (140 MPa.s at 5%) (0.381 g/30mL) Lotion Rectal; Vaginal Shenzhen ZhiHuiChuangXiang Technology Co., Ltd 2019-03-27 Not applicable US WeDol Water-based personal lubricant Hydroxyethyl cellulose (140 MPa.s at 5%) (3.84 g/240mL) Oil Topical Shenzhenshi Huaxiang Technology Co.,Ltd. 2019-09-15 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as o-glycosyl compounds. These are glycoside in which a sugar group is bonded through one carbon to another group via a O-glycosidic bond.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- O-glycosyl compounds
- Alternative Parents
- Disaccharides / Oxanes / Secondary alcohols / Oxacyclic compounds / Dialkyl ethers / Acetals / Hydrocarbon derivatives
- Substituents
- Acetal / Alcohol / Aliphatic heteromonocyclic compound / Dialkyl ether / Disaccharide / Ether / Hydrocarbon derivative / O-glycosyl compound / Organoheterocyclic compound / Oxacycle
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- T4V6TWG28D
- CAS number
- 9004-62-0
- InChI Key
- DFJVHKAPIXJTSC-UHFFFAOYSA-N
- InChI
- InChI=1S/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3
- IUPAC Name
- 1-{[3,4,5-tris(2-hydroxypropoxy)-6-{[4,5,6-tris(2-hydroxypropoxy)-2-[(2-hydroxypropoxy)methyl]oxan-3-yl]oxy}oxan-2-yl]methoxy}propan-2-ol
- SMILES
- CC(O)COCC1OC(OC2C(COCC(C)O)OC(OCC(C)O)C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C(OCC(C)O)C1OCC(C)O
References
- General References
- Mianehrow H, Moghadam MH, Sharif F, Mazinani S: Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82. doi: 10.1016/j.ijpharm.2015.02.069. Epub 2015 Feb 28. [Article]
- Wang J, Somasundaran P: Mechanisms of ethyl(hydroxyethyl) cellulose-solid interaction: influence of hydrophobic modification. J Colloid Interface Sci. 2006 Jan 15;293(2):322-32. Epub 2005 Aug 2. [Article]
- Giandalia G, De Caro V, Cordone L, Giannola LI: Trehalose-hydroxyethylcellulose microspheres containing vancomycin for topical drug delivery. Eur J Pharm Biopharm. 2001 Jul;52(1):83-9. [Article]
- Durand-Cavagna G, Delort P, Duprat P, Bailly Y, Plazonnet B, Gordon LR: Corneal toxicity studies in rabbits and dogs with hydroxyethyl cellulose and benzalkonium chloride. Fundam Appl Toxicol. 1989 Oct;13(3):500-8. [Article]
- Baranowski P, Karolewicz B, Gajda M, Pluta J: Ophthalmic drug dosage forms: characterisation and research methods. ScientificWorldJournal. 2014 Mar 18;2014:861904. doi: 10.1155/2014/861904. eCollection 2014. [Article]
- Mortazavi SA, Jaffariazar Z, Damercheli E: Formulation and In-Vitro Evaluation of Ocular Ciprofloxacin-Containing Minitablets Prepared with Different Combinations of Carbopol 974P and Various Cellulose Derivatives. Iran J Pharm Res. 2010 Spring;9(2):107-14. [Article]
- Cellosize product information [Link]
- External Links
- KEGG Drug
- D04474
- PubChem Compound
- 4327536
- PubChem Substance
- 347828003
- ChemSpider
- 3532118
- 27244
- ChEBI
- 85249
- ChEMBL
- CHEMBL2109076
- Wikipedia
- Hydroxyethyl_cellulose
- MSDS
- Download (297 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Basic Science Dry Eyes 1 1 Completed Prevention Human Immunodeficiency Virus (HIV) Infections 1 Not Available Unknown Status Treatment Angle-Closure Glaucoma / Glaucoma, Closed-Angle / Narrow-angle glaucoma 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution / drops Ophthalmic Kit Intrauterine Liquid Topical Emulsion Topical Solution / drops Ophthalmic Solution / drops Ophthalmic 0.35 mg/1mL Solution Ophthalmic Liquid Ophthalmic 6 mg/1mL Lotion Rectal; Vaginal 0.381 g/30mL Oil Topical 3.84 g/240mL - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US9034300 No 2015-05-19 2030-10-15 US US9259494 No 2016-02-16 2035-05-04 US US9849199 No 2017-12-26 2036-02-11 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) Decomposes at 205ºC as Cellosize Cellosize product information water solubility Soluble MSDS - Predicted Properties
Property Value Source Water Solubility 2.85 mg/mL ALOGPS logP -1.1 ALOGPS logP -1.7 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 13.95 Chemaxon pKa (Strongest Basic) -2.9 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 19 Chemaxon Hydrogen Donor Count 8 Chemaxon Polar Surface Area 263.37 Å2 Chemaxon Rotatable Bond Count 28 Chemaxon Refractivity 192.04 m3·mol-1 Chemaxon Polarizability 87.56 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 263.16147 predictedDeepCCS 1.0 (2019) [M+H]+ 265.17496 predictedDeepCCS 1.0 (2019) [M+Na]+ 270.91537 predictedDeepCCS 1.0 (2019)
Drug created at June 01, 2016 19:25 / Updated at September 28, 2021 21:54