Indium In-111 chloride
Identification
- Summary
Indium In-111 chloride is a diagnostic radiopharmaceutical agent used for radiolabelling monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures.
- Brand Names
- Indiclor, Octreoscan
- Generic Name
- Indium In-111 chloride
- DrugBank Accession Number
- DB09490
- Background
Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in O.04M HCI.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 217.26
Monoisotopic: 215.8116688 - Chemical Formula
- Cl3In
- Synonyms
- 111indium trichloride
- Indium (111In) chloride
- Indium chloride (111InCl3)
- Indium chloride In-111
- Indium In 111 chloride
- Indium In 111m chloride
- Indium In-111m chloride
- Indium-111 chloride
Pharmacology
- Indication
Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for diagnostic process Gastrointestinal tumors Combination Product in combination with: Indium In-111 pentetreotide (DB11835) •••••••••••• •••••••••• ••••••• ••• •••••••• Used in combination for diagnostic process Pancreatic tumours Combination Product in combination with: Indium In-111 pentetreotide (DB11835) •••••••••••• •••••••••• ••••••• ••• •••••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone
- Mechanism of action
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone
- Absorption
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone
- Volume of distribution
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone
- Protein binding
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone
- Metabolism
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone
- Route of elimination
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone
- Half-life
2.8 days
- Clearance
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Drink plenty of fluids. Fluids will help remove excess radiation from the body when Indium In-111 chloride is used to radiolabel pentetreotide.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Indium cation In-111 ionic WJZ06C0H8L 131391-70-3 RJMMFJHMVBOLGY-AHCXROLUSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Indiclor Solution 5 mCi/0.5mL Intravenous Medi-Physics Inc. 1992-12-29 2019-06-06 US Indium In 111 Chloride Solution 10 mCi/1mL Intravenous Curium US LLC 2007-12-07 Not applicable US Indium In 111 Chloride Solution 10 mCi/1mL Intravenous Mallinckrodt 2007-12-07 2017-07-01 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Octreoscan Indium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL) Kit Intravenous Curium US LLC 2015-10-14 Not applicable US Octreoscan Indium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL) Kit Intravenous Mallinckrodt 2007-05-01 2017-07-01 US OCTREOSCAN Indium In-111 chloride (111 MBq/ml) + Indium In-111 pentetreotide (10 mcg) Injection, powder, for solution Intravenous Curium Netherlands B.V. 2014-07-08 Not applicable Italy OctreoScan - Pulver zur Herstellung einer Injektionslösung Indium In-111 chloride (111 MBq/ml) + Pentetreotide (10 mcg) Injection, powder, for solution Intravenous Curium Netherlands B.V. 1999-07-15 Not applicable Austria OCTREOSCAN FOR INJECTION Indium In-111 chloride (122 MBq/1.1ml) + Pentetreotide (10 mcg) Injection, powder, for solution Intravenous QT INSTRUMENTS (S) PTE LTD 1999-12-16 Not applicable Singapore
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal salts
- Sub Class
- Post-transition metal chlorides
- Direct Parent
- Post-transition metal chlorides
- Alternative Parents
- Inorganic chloride salts
- Substituents
- Inorganic chloride salt / Inorganic salt / Post-transition metal chloride
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 58TD96H03I
- CAS number
- 50800-85-6
- InChI Key
- PSCMQHVBLHHWTO-FZTWWWDYSA-K
- InChI
- InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
- IUPAC Name
- trichloro(¹¹¹In)indigane
- SMILES
- Cl[111In](Cl)Cl
References
- General References
- FDA label [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Terminated Diagnostic Solid Tumors 1 1, 2 Terminated Diagnostic Gastroenteropancreatic Neuroendocrine Tumors 1 Not Available Completed Diagnostic Sarcoidosis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous 5 mCi/0.5mL Solution Intravenous Injection, solution Intravenous Injection, solution Intrathecal Injection Intravenous 370 MBq/ml Solution Intravenous 10 mCi/1mL Kit Intravenous Injection, powder, for solution Intravenous - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6123916 No 2000-09-26 2017-09-26 US US5776894 No 1998-07-07 2015-07-07 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 27.4 mg/mL ALOGPS logP 1.69 ALOGPS logP 1.9 Chemaxon logS -0.91 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 18.41 m3·mol-1 Chemaxon Polarizability 9.87 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 30, 2015 19:10 / Updated at February 13, 2021 10:51