Manganese

Identification

Summary

Manganese is a transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).

Brand Names
Concept Ob, Multitrace-4, Multitrace-5, Multrys, Tandem Plus
Generic Name
Manganese
DrugBank Accession Number
DB06757
Background

Manganese is a transition metal with a molar mass of 54.94g/mol. Manganese is considered critical for human health, and plays important roles in development, metabolism, and the antioxidant system. That said, excessive manganese intake is associated with manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms.

Type
Small Molecule
Groups
Approved, Nutraceutical
Structure
Weight
Average: 54.938
Monoisotopic: 54.938049636
Chemical Formula
Mn
Synonyms
Not Available

Pharmacology

Indication

Indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialNot AvailableHumans
UIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialNot AvailableHumans
UTGF-beta-activated kinase 1 and MAP3K7-binding protein 1Not AvailableHumans
UArginase-1Not AvailableHumans
USerotransferrinNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Manganese chloride6YB4901Y907773-01-5GLFNIEUTAYBVOC-UHFFFAOYSA-L
Manganese chloride tetrahydrateQQE170PANO13446-34-9CNFDGXZLMLFIJV-UHFFFAOYSA-L
Manganese sulfateW00LYS4T2610034-96-5ISPYRSDWRDQNSW-UHFFFAOYSA-L
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
ManganeseInjection, solution0.1 mg/1mLIntravenousHospira, Inc.2005-01-31Not applicableUS flag
Manganese SulfateInjection, solution0.1 mg/1mLIntravenousAMERICAN REGENT, INC.1990-09-30Not applicableUS flag
Micro MnSolution0.5 mg / mLIntravenousSandoz Canada Incorporated1992-12-312018-08-01Canada flag
Micro MnSolution0.1 mg / mLIntravenousSandoz Canada Incorporated1992-12-31Not applicableCanada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Bio-plex Tab 0.95mgTablet.95 mg / tabOralTherapeutic Foods Co.1988-12-312001-07-31Canada flag
Chelated Manganese Tablets - 5mgTablet5 mgOralAlbion1996-09-062002-07-12Canada flag
Chelazome Manganese Cap 15mgCapsule15 mgOralTrophic Canada Ltd.1987-12-312008-08-28Canada flag
Hvp Chelated Manganese 30mgTablet30 mg / tabOralSwiss Herbal Remedies Ltd.1999-09-162003-09-10Canada flag
ManganeseCapsule30 mgOralSeroyal International Inc.1993-12-312009-07-06Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
24 Multivitamins + MineralsManganese (2 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada flag
50 Plus Multiple Vitamins & MineralsManganese (5 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada flag
A.R.T.H. Away FormulaManganese (0.58 mg) + Calcium (24 mg) + Cholecalciferol (45 unit) + Copper (0.232 mg) + Folic acid (0.025 mg) + Pyridoxine hydrochloride (0.5 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg)CapsuleOralAbundance Naturally Ltd1999-02-012006-06-16Canada flag
A/o-26 - CapletManganese (2.5 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada flag
Acti-MN + B1 + C CapletManganese (30.0 mg) + Calcium ascorbate (100 mg) + Thiamine hydrochloride (20 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Addamel NManganese chloride tetrahydrate (0.027 mg/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL)Injection, solutionIntravenousFresenius Kabi USA, LLC2013-05-072017-03-31US flag
ADDAMEL N 20 AMPULManganese chloride (990 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2019-04-30Not applicableTurkey flag
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYONManganese chloride (198 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL)Injection, solutionIntravenousFRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ.2016-09-062022-11-10Turkey flag
CentratexManganese sulfate (1.3 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs, LLC2009-06-14Not applicableUS flag
Concept OBManganese sulfate (1.3 mg/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cupric sulfate pentahydrate (800 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (42.5 mg/1) + Folic acid (1 mg/1) + Iron (42.5 mg/1) + Magnesium sulfate (6.9 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralU.S. Pharmaceutical Corporation2009-01-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous metal compounds
Class
Homogeneous transition metal compounds
Sub Class
Not Available
Direct Parent
Homogeneous transition metal compounds
Alternative Parents
Not Available
Substituents
Homogeneous transition metal
Molecular Framework
Not Available
External Descriptors
monoatomic dication, divalent metal cation, manganese cation (CHEBI:29035) / a cation (MN+2)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
H6EP7W5457
CAS number
7439-96-5
InChI Key
WAEMQWOKJMHJLA-UHFFFAOYSA-N
InChI
InChI=1S/Mn/q+2
IUPAC Name
manganese(2+) ion
SMILES
[Mn++]

References

General References
  1. Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [Article]
Human Metabolome Database
HMDB0001333
KEGG Drug
D04854
KEGG Compound
C19610
PubChem Compound
27854
PubChem Substance
310264880
ChemSpider
25916
RxNav
6623
ChEBI
29035
ChEMBL
CHEMBL2103742
PDBe Ligand
MN
Drugs.com
Drugs.com Drug Page
Wikipedia
Manganese
PDB Entries
117e / 1a0d / 1a0o / 1a16 / 1a3w / 1a3x / 1a5v / 1a6q / 1a76 / 1a9x
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MSDS
Download (61.4 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Not Yet RecruitingTreatmentManganese Safety in Adults1
4Not Yet RecruitingTreatmentManganese Safety in Pediatric Patients1
2CompletedTreatmentCentral Serous Chorioretinopathy (CSC)1
2CompletedTreatmentOvarian Cancer1
2, 3CompletedTreatmentSubstance Abuse / Substance Dependence1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
InjectionIntravenous5.33 mcg/ml
Injection, solutionIntravenous drip
SolutionIntravenous5.33 mcg/ml
TabletOral.95 mg / tab
TabletOral5 mg
CapsuleOral15 mg
Tablet, extended releaseOral
Tablet, film coated
Tablet, coatedOral
Tablet
Capsule
CapsuleCutaneous; Oral
LiquidOral
Tablet, delayed releaseOral
CapsuleOral
PowderOral
Tablet, effervescentOral
Capsule, coatedOral
CapsuleOral30 mg
TabletOral30 mg / tab
TabletOral15 mg / tab
TabletOral50 mg / tab
Injection, solutionIntravenous0.1 mg/1mL
KitOral
Tablet, film coatedOral
SolutionIntravenous0.1 mg / mL
SolutionIntravenous0.5 mg / mL
LiquidIntravenous
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
Capsule, liquid filledOral
SolutionIntravenous0.053 mg/10ml
SolutionOral
TabletOral6 mg / tab
TabletOral4 mg / tab
Injection, solution, concentrateIntravenous; Parenteral
Injection, solution, concentrateParenteral
Solution, concentrateIntravenous
InjectionIntravenous
Tablet, chewableOral
TabletOral
Capsule, gelatin coatedOral
SolutionIntravenous
Injection, solutionParenteral
Powder, for solutionOral
TabletOral300.000 mg
Tablet, sugar coatedOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US11786548No2021-07-012041-07-01US flag

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)1246Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72
boiling point (°C)2061Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72
Predicted Properties
PropertyValueSource
logP-0.16Chemaxon
pKa (Strongest Acidic)3.09Chemaxon
Physiological Charge2Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity0 m3·mol-1Chemaxon
Polarizability1.78 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Nad binding
Specific Function
Not Available
Gene Name
IDH3A
Uniprot ID
P50213
Uniprot Name
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Molecular Weight
39591.365 Da
References
  1. Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Nad binding
Specific Function
Not Available
Gene Name
IDH3G
Uniprot ID
P51553
Uniprot Name
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
Molecular Weight
42793.97 Da
References
  1. Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Protein serine/threonine phosphatase activity
Specific Function
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Gene Name
TAB1
Uniprot ID
Q15750
Uniprot Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Molecular Weight
54643.655 Da
References
  1. Conner SH, Kular G, Peggie M, Shepherd S, Schuttelkopf AW, Cohen P, Van Aalten DM: TAK1-binding protein 1 is a pseudophosphatase. Biochem J. 2006 Nov 1;399(3):427-34. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Manganese ion binding
Specific Function
Not Available
Gene Name
ARG1
Uniprot ID
P05089
Uniprot Name
Arginase-1
Molecular Weight
34734.655 Da
References
  1. Zakharian TY, Di Costanzo L, Christianson DW: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. Org Biomol Chem. 2008 Sep 21;6(18):3240-3. doi: 10.1039/b811797g. Epub 2008 Aug 6. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transferrin receptor binding
Specific Function
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from si...
Gene Name
TF
Uniprot ID
P02787
Uniprot Name
Serotransferrin
Molecular Weight
77063.195 Da
References
  1. Golub MS, Han B, Keen CL: Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures. Brain Res. 1996 May 6;719(1-2):72-7. [Article]

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Rna binding
Specific Function
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron whe...
Gene Name
ACO1
Uniprot ID
P21399
Uniprot Name
Cytoplasmic aconitate hydratase
Molecular Weight
98398.14 Da
References
  1. Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [Article]

Drug created at September 14, 2010 16:21 / Updated at March 28, 2024 06:08