Clothiapine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Clothiapine is an atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety.

Generic Name
Clothiapine
DrugBank Accession Number
DB13256
Background

Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 343.87
Monoisotopic: 343.0909965
Chemical Formula
C18H18ClN3S
Synonyms
  • Clothiapine
  • Clotiapina
  • Clotiapine
External IDs
  • HF-2159

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofAcute exacerbation of psychosis•••••••••••••••••••••• ••••••••• •••••••• • •••••• ••••••
Treatment ofAcute psychosis•••••••••••••••••••••• ••••••••• •••••••• • •••••• ••••••
Treatment ofChronic psychosis•••••••••••••••••••••• ••••••••• •••••••• • •••••• ••••••
Treatment ofNeurotic disorders•••••••••••••••••••••• ••••••••• •••••••• • •••••• ••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Clothiapine.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Clothiapine.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Clothiapine.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Clothiapine.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Clothiapine.
Food Interactions
Not Available

Products

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Categories

ATC Codes
N05AH06 — Clotiapine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dibenzothiazepines. These are compounds containing a dibenzothiazepine moiety, which consists of two benzene connected by a thiazepine ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzothiazepines
Sub Class
Dibenzothiazepines
Direct Parent
Dibenzothiazepines
Alternative Parents
Diarylthioethers / N-methylpiperazines / Imidolactams / Benzenoids / Aryl chlorides / Trialkylamines / Propargyl-type 1,3-dipolar organic compounds / Carboxamidines / Azacyclic compounds / Organopnictogen compounds
show 2 more
Substituents
1,4-diazinane / Amidine / Amine / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Aryl thioether / Azacycle / Benzenoid / Carboxylic acid amidine
show 17 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
Z05HCY0X1T
CAS number
2058-52-8
InChI Key
KAAZGXDPUNNEFN-UHFFFAOYSA-N
InChI
InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
IUPAC Name
13-chloro-10-(4-methylpiperazin-1-yl)-2-thia-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,9,12,14-heptaene
SMILES
CN1CCN(CC1)C1=NC2=CC=CC=C2SC2=C1C=C(Cl)C=C2

References

General References
  1. AIFA Product Information: Entumin (clothiapine) for oral or parenteral administration [Link]
ChemSpider
15510
BindingDB
50040237
RxNav
2620
ChEBI
31424
ChEMBL
CHEMBL304902
ZINC
ZINC000026185346
Wikipedia
Clotiapine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Unknown StatusTreatmentPsychosis Nos/Other1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntramuscular; Intravenous40 MG/4ML
Solution / dropsOral100 MG/ML
TabletOral40 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0142 mg/mLALOGPS
logP4.1ALOGPS
logP4.15Chemaxon
logS-4.4ALOGPS
pKa (Strongest Basic)7.23Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area18.84 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity101.55 m3·mol-1Chemaxon
Polarizability36.73 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0009000000-b0dd3c115d5539047b24
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0009000000-a1d58a6b1ba65b8544c0
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0029000000-04df24e1dac79ce9a7a7
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0049000000-c1e503e7d5129c991b1f
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00kv-0190000000-247f639d9cb8c01d6c7a
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0089-6192000000-5166fc65479c9eb8f7b2
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-171.48598
predicted
DeepCCS 1.0 (2019)
[M+H]+173.844
predicted
DeepCCS 1.0 (2019)
[M+Na]+179.93712
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:38 / Updated at June 05, 2021 09:13