Mrv1718008081814082D          

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  1  2  1  0  0  0  0
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 20 24  2  0  0  0  0
M  END
> <DATABASE_ID>
DB00381

> <DATABASE_NAME>
drugbank

> <SMILES>
CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

> <INCHI_IDENTIFIER>
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3

> <INCHI_KEY>
HTIQEAQVCYTUBX-UHFFFAOYSA-N

> <FORMULA>
C20H25ClN2O5

> <MOLECULAR_WEIGHT>
408.876

> <EXACT_MASS>
408.145199627

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
53

> <JCHEM_AVERAGE_POLARIZABILITY>
42.31141604801554

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

> <ALOGPS_LOGP>
2.22

> <JCHEM_LOGP>
1.6355954516666678

> <ALOGPS_LOGS>
-4.74

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.12333262212675

> <JCHEM_PKA_STRONGEST_BASIC>
9.445646936621939

> <JCHEM_POLAR_SURFACE_AREA>
99.88

> <JCHEM_REFRACTIVITY>
108.63810000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
10

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.40e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
amlodipine

> <JCHEM_VEBER_RULE>
0

> <DRUGBANK_ID>
DB00381

> <SECONDARY_ACCESSION_NUMBERS>
APRD00520

> <DRUG_GROUPS>
approved

> <GENERIC_NAME>
Amlodipine

> <SYNONYMS>
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; Amlodipine; Amlodipine free base; Amlodipino; Amlodipinum

> <PRODUCTS>
AMLODIPINE BESYLATE 10 mg; AMLODIPINE BESYLATE 2.5 mg; AMLODIPINE BESYLATE 5 mg; AMLODIPINE and OLMESARTAN medoxomil; AMLODIPINE and VALSARTAN; Accel-amlodipine; Ach-amlodipine; Act Amlodipine; Ag-amlodipine; Amlobenz; Amlodipine; Amlodipine Besylate; Amlodipine Besylate Tablets, 10mg; Amlodipine Besylate Tablets, 5mg; Amlodipine Besylate and Atorvastatin Calcium; Amlodipine Besylate and Benazepril HCL; Amlodipine Besylate and Benazepril Hydrochloride; Amlodipine Besylate and Olmesartan Medoxomil; Amlodipine Tablets; Amlodipine and Atorvastatin; Amlodipine and Benazepril Hydrochloride; Amlodipine and Olmesartan Medoxomil; Amlodipine and Valsartan; Amlodipine and atorvastatin; Amlodipine and olmesartan Medoxomil; Amlodipine and olmesartan medoxomil; Amlodipine and valsartan; Amlodipine besylate; Amlodipine besylate and Atorvastatin calcium; Amlodipine besylate and Benazepril hydrochloride; Amlodipine besylate and Olmesartan medoxomil; Amlodipine besylate and Olmesartran medoxomil; Amlodipine besylate and benazepril hydrochloride; Amlodipine besylate/atorvastatin calcium; Amlodipine, Valsartan and Hydrochlorothiazide; Amlodipine, Valsartan, Hydrochlorothiazide; Amlodipine, Valsartan, and Hydrochlorothiazide; Amlodipine-odan; Amlodipine-valsartan Mylan; Amoldipine Benazepril HCl; Amturnide; Apo-amlodipine; Apo-amlodipine-atorvastatin; Apo-perindopril/amlodipine; Apo-telmisartan-amlodipine; Auro-amlodipine; Ava-amlodipine; Azor; Bio-amlodipine; Caduet; Consensi; Copalia; Copalia HCT; Dafiro; Dafiro HCT; Dom-amlodipine; Exforge; Exforge HCT; Gd-amlodipine; Hypertenipine; Imprida; Imprida HCT; Ipg-amlodipine; Jamp-amlodipine; Katerzia; Lotrel; M-amlodipine; Manda-amlodipine Tablets; Mar-amlodipine; Mint-amlodipine; Mylan-amlodipine; Mylan-amlodipine/atorvastatin; Norliqva; Norvasc; Nra-amlodipine; Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg; Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg; PHL-amlodipine; PMS-amlodipine; PMS-amlodipine Mesylate; PMS-amlodipine-atorvastatin; PMS-perindopril-amlodipine; Pdp-amlodipine; Pendo-amlodipine-atorvastatin; Pharma-amlodipine; Prestalia; Prz-amlodipine; Q-amlodipine; Q-gen Amlodipine; Ran-amlodipine; Ratio-amlodipine Tablets 10mg; Ratio-amlodipine Tablets 5mg; Riva-amlodipine; Sandoz Amlodipine; Septa-amlodipine; Taro-amlodipine; Tekamlo; Telmisartan and Amlodipine; Teva-amlodipine; Tribenzor; Twynsta; Van-amlodipine; Viacoram; Zym-amlodipine

> <INTERNATIONAL_BRANDS>
Aforbes; Agen; Aken; Amcard; Amdepin; Amdipin; Amilostad; Amlocard; Amlod; Amlodine; Amlodipin; Amlodipin-Mepha 5/10; Amlodipine 5; Amlodis; Amlong; Amlopin; Amlopine; Amlostin; Amlosun; Amlovas; Amlovasc; Amlozek; Amvaz; Asomex; Atecard-AM; Camlodin; Cardilopina; Coroval; Dailyvasc; Istin; Lama; Lodip; Lodopin; Lopin; Nelod; Nopidin; Nordip; Perivasc; Pharex Amlodipine; Tenox

> <SALTS>
Amlodipine benzoate; Amlodipine besylate; Amlodipine camsylate; Amlodipine maleate; Amlodipine mesylate; Amlodipine mesylate monohydrate

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