836
  Mrv0541 02231215022D          

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M  END
> <DATABASE_ID>
DB00836

> <DATABASE_NAME>
drugbank

> <SMILES>
CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3

> <INCHI_KEY>
RDOIQAHITMMDAJ-UHFFFAOYSA-N

> <FORMULA>
C29H33ClN2O2

> <MOLECULAR_WEIGHT>
477.038

> <EXACT_MASS>
476.223056017

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
67

> <JCHEM_AVERAGE_NEUTRAL_MICROSPECIES_CHARGE>
0.9961182776434693

> <JCHEM_AVERAGE_POLARIZABILITY>
52.59475664282138

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

> <ALOGPS_LOGP>
4.44

> <JCHEM_LOGP>
4.771190858666666

> <ALOGPS_LOGS>
-5.74

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NEUTRAL_CHARGE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.964882601505003

> <JCHEM_PKA_STRONGEST_BASIC>
9.409298603197188

> <JCHEM_POLAR_SURFACE_AREA>
43.78

> <JCHEM_REFRACTIVITY>
139.31900000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.60e-04 g/l

> <JCHEM_TRADITIONAL_IUPAC>
tetrahydrofolic acid

> <JCHEM_VEBER_RULE>
0

> <DRUGBANK_ID>
DB00836

> <SECONDARY_ACCESSION_NUMBERS>
APRD00275

> <DRUG_GROUPS>
approved

> <GENERIC_NAME>
Loperamide

> <SYNONYMS>
Loperamid; Loperamida; Lopéramide; Loperamide; Loperamidum

> <PRODUCTS>
7 Select Anti Diarrheal; A D; ANTI-DIARRHEAL LOPERAMIDE HCL, 2 mg caplets; Alti-loperamide - 2mg Caplet; Anti Diarrheal; Anti Diarrheal Anti Gas; Anti Diarrheal Plus Anti Gas; Anti Diarrheal and Anti Gas; Anti-Diarrheal; Anti-Diarrheal 24/7 for Life by 7-Eleven; Anti-Diarrheal Loperamide HCl; Anti-Diarrheal loperamide HCl; Anti-Diarrheal, CVP HEALTH; Anti-Diarrheal, Caseys 4good; Anti-Diarrheal, Circle K; Anti-Diarrheal/Anti-Gas Multi-Symptom Relief; Anti-diarrheal; Anti-diarrheal Caplets - 2mg; Antidiarrheal Multi Symptom Relief; Antidiarrheal Relief; Apo-loperamide; Basic Care Loperamide Hydrochloride; Basic Care Loperamide Hydrochloride and Simethicone; Basic Care loperamide hydrochloride; Berkley and Jensen Anti Diarrheal; Care One Anti Diarrheal; Care One anti diarrheal loperamide hydrochloride; CareOne Diarrhea Control; CareOne Diarrhea and Gas Control; CareOne Loperamide Hydrochloride; CareOne loperamide hydrochloride; Circle K Anti-Diarrheal; Core Values Anti Diarrheal; DG Health Anti Diarrheal; Dg Health Anti Diarrheal; Dg Health Anti Diarrheal Anti Gas; Dg Health Loperamide Hydrochloride; Diahalt Caplets - 2mg; Diarr-eze; Diarr-eze - Liq Orl 0.2mg/ml; Diarrhea Relief; Diarrhea Relief - Caplets 2mg; Diarrhea Relief Fast Dissolve; Diarrhea Relief Liquid Gels; Doc in the Box All Day Supply; Dom-loperamide Caplets 2mg; Dom-loperamide Hydrochloride Solution-orl; Enterocina; Equaline Anti Diarrheal; Equaline Anti Diarrheal Plus Anti Gas; Equaline Loperamide Hydrochloride; Equaline loperamide hydrochloride; Equate Anti Diarrheal Anti Gas; Equate Diarrhea Control; Equate Loperamide Hydrochloride; Equate anti diarrheal; Fad First Aid Direct Anti-diarrheal; Family Wellness Anti Diarrheal; Family Wellness Anti Diarrheal Plus Anti Gas; Family Wellness Anti Diarrheal Plus Multi Symptom Relief; First Aid Direct Anti-Diarrheal; Foster and Thrive Anti Diarrheal; Foster and Thrive Anti Diarrheal Anti Gas; Foster and Thrive Anti-diarrheal; Gadavyt Loperamide HCl; Good Neighbor Pharmacy Anti Diarrheal; Good Neighbor Pharmacy Anti Diarrheal Anti Gas; Good Neighbor Pharmacy Loperamide Hydrochloride; Good Sense Anti Diarrheal; Good Sense Anti Diarrheal Anti Gas; Good Sense Loperamide Hydrochloride; Good Sense anti diarrheal; Good Sense antidiarrheal; Goodnow Diarrhea Relief; Handy Solutions Anti-Diarrheal; Harmon Face Values Anti Diarrheal; Harris Teeter Anti Diarrheal; Harris Teeter Loperamide Hydrochloride; Health Mart Anti Diarrheal; Health Mart Anti Diarrheal Anti Gas; Health Mart Loperamide Hydrochloride; Healthy Accents Anti Diarrheal; IMODIUM Multi-Symptom Relief; Ibs Labs - Anti-diarrheal Original Prescription Strength, 2 mg; Imodium; Imodium - Caplet 2mg; Imodium A-D; Imodium AD; Imodium Calming Liquid; Imodium Cap 2mg; Imodium Caplets 2mg; Imodium Complete; Imodium Complete Chewable Tablets; Imodium Liqui-gels; Imodium Oral Sol 0.2mg/ml; Imodium Quick Dissolve; Injoy Diarrhea Relief; Intestinomicina; Kirkland Signature Anti Diarrheal; Leader Anti Diarrheal; Leader Anti-diarrheal; Leader Loperamide; Leader Loperamide Hydrochloride; Lil Drug Store Anti-Diarrheal; Lil Drug Store Anti-Diarrheal Soft Gelatin; Loperacap; Loperamide; Loperamide HCl; Loperamide HCl Anti-Diarrheal; Loperamide HCl and Simethicone; Loperamide Hydrochloride; Loperamide Hydrochloride and Simethicone; Loperamide Hydrochloride, Simethicone; Loperamide hydrochloride; Loperamide hydrochloride and Simethicone; Loperamide-2; MEDIQUE Diamode; Medex Anti-Diarrheal Relief; Meds on the Go; PHL-loperamide; PMS-loperamide - Caplet 2mg; PMS-loperamide Hydrochloride Solution.2mg/ml; Physicians Care Anti-Diarrheal; Preferred Plus Loperamide; Preferred Plus Loperamide Hydrochloride; Rexall Anti Diarrheal; Rhoxal-loperamide; Riva-loperamide; Rx Act Anti Diarrheal; Sandoz Loperamide; ShopRite Anti Diarrheal; Signature Care Anti Diarrheal; Signature Care Anti Diarrheal Anti Gas; Simply Right Anti Diarrheal; Smart Sense Anti Diarrheal; Smart Sense Loperamide Hydrochloride; Smart Sense anti diarrheal; Stomach Relief Anti Diarrheal; Sunmark Anti Diarrheal; Sunmark Loperamide Hydrochloride; Teva-loperamide; Topcare Anti Diarrheal; Topcare Anti Diarrheal Anti Gas; Topcare Loperamide Hydrochloride; Up and Up Anti Diarrheal Anti Gas; Up and Up anti diarrheal; Vaprino A-D; WELMATE Anti Diarrheal Loperamide HCl; WELMATE Anti Diarrheal Loperamide HCl Softgels; Welly Travel Medicine Kit; good neighbor pharmacy Loperamide hydrochloride

> <INTERNATIONAL_BRANDS>
Dimor; Fortasec; Kaopectate II; Lopedium; Lopedium express; Lopex; Maalox Anti-Diarrheal; Pepto Diarrhea Control

> <SALTS>
Loperamide hydrochloride

$$$$