1085
  Mrv0541 02231215142D          

 15 16  0  0  1  0            999 V2000
    4.1277   -1.4158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8178   -2.0833    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1834    0.7557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3229    2.0833    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7152   -0.1463    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.0478   -0.6312    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7152    0.6787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3827   -0.6312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2631   -0.3763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3027   -1.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4297    1.0913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.9283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5160    1.9117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7354    1.3688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3549   -0.0513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  8  1  0  0  0  0
  1 10  1  0  0  0  0
  2 10  2  0  0  0  0
  3 11  1  0  0  0  0
  3 14  1  0  0  0  0
  3 15  1  0  0  0  0
  4 13  1  0  0  0  0
  4 14  2  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
M  END
> <DATABASE_ID>
DB01085

> <DATABASE_NAME>
drugbank

> <SMILES>
CC[C@H]1[C@@H](CC2=CN=CN2C)COC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1

> <INCHI_KEY>
QCHFTSOMWOSFHM-WPRPVWTQSA-N

> <FORMULA>
C11H16N2O2

> <MOLECULAR_WEIGHT>
208.2569

> <EXACT_MASS>
208.121177766

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
31

> <JCHEM_AVERAGE_NEUTRAL_MICROSPECIES_CHARGE>
0.18896039642523255

> <JCHEM_AVERAGE_POLARIZABILITY>
22.339274635707056

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]oxolan-2-one

> <ALOGPS_LOGP>
1.15

> <JCHEM_LOGP>
0.949751419333334

> <ALOGPS_LOGS>
-2.00

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NEUTRAL_CHARGE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
6.367328729786709

> <JCHEM_POLAR_SURFACE_AREA>
44.120000000000005

> <JCHEM_REFRACTIVITY>
56.53419999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.07e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
biotin

> <JCHEM_VEBER_RULE>
0

> <DRUGBANK_ID>
DB01085

> <SECONDARY_ACCESSION_NUMBERS>
APRD00382

> <DRUG_GROUPS>
approved; investigational

> <GENERIC_NAME>
Pilocarpine

> <SYNONYMS>
2(3H)-FURANONE, 3-ETHYLDIHYDRO-4-((1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-, (3S-CIS)-; OCUCARPINE; Pilocarpina; Pilocarpine; PILOKARPIN; SPERSACARPINE; SYNCARPINE

> <PRODUCTS>
Betoptic Pilo; Betoptic/pilo; E-pilo 1 Ophthalmic Solution; E-pilo 2 Ophthalmic Solution; E-pilo 4 Ophthalmic Solution; E-pilo 6 Ophthalmic Solution; E-pilo-1 Oph Soln; E-pilo-2 Oph Soln; E-pilo-4 Oph Soln; E-pilo-6 Oph Soln; Isopto Carpine; Isopto Carpine 0.5%; Isopto Carpine Liq 6%; Jamp Pilocarpine; M-pilocarpine; Minims Pilocarpine Nitrate; Minims Pilocarpine Nitrate 4%; Miocarpine Oph Soln 1%; Miocarpine Oph Soln 2%; Miocarpine Oph Soln 4%; Miocarpine Oph Soln 6%; Miocarpine Ophthalmic Solution 1%; Miocarpine Ophthalmic Solution 2%; Miocarpine Ophthalmic Solution 4%; Miocarpine Ophthalmic Solution 6%; Ocusert Pilo 20; Ocusert Pilo 40; Odan-pilocarpine; PMS-pilocarpine 0.5%; PMS-pilocarpine 1%; PMS-pilocarpine 2%; PMS-pilocarpine 4%; PMS-pilocarpine 6%; Pilocarpine; Pilocarpine 1%; Pilocarpine 2%; Pilocarpine 4%; Pilocarpine 6%; Pilocarpine Hydrchloride; Pilocarpine Hydrochloride; Pilocarpine Hydrochloride 1% - Liq Oph; Pilocarpine Hydrochloride 2% - Liq Oph; Pilocarpine Hydrochloride 4% - Liq Oph; Pilocarpine Hydrochloride Ophthalmic Solution 1% USP; Pilocarpine Hydrochloride Ophthalmic Solution 2% USP; Pilocarpine Hydrochloride Ophthalmic Solution 4% USP; Pilocarpine Hydrochloride Tablets; Pilocarpine Hydrochloride Tablets, USP; Pilocarpine hydrochloride; Pilopine Hs; Pilopine Hs 4%; R.O. -carpine 1%; R.O.-carpine 2%; R.O.-carpine 4%; Salagen; Timpilo 2; Timpilo 4; Vuity; pilocarpine Hydrochloride

> <INTERNATIONAL_BRANDS>
Diocarpine; Miocarpine; Pilostat; Pilovisc; Timpilo

> <SALTS>
Pilocarpine hydrochloride; Pilocarpine nitrate; Pilocarpine pamoate

$$$$