Multidrug resistance protein MdtK

Details

Name
Multidrug resistance protein MdtK
Synonyms
  • Multidrug-efflux transporter
Gene Name
mdtK
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0020406|Multidrug resistance protein MdtK
MQKYISEARLLLALAIPVILAQIAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILF
GHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLIMLVLWNAGYIIRSMENID
PALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIY
GHFGMPELGGVGCGVATAAVYWVMFLAMVSYIKRARSMRDIRNEKGTAKPDPAVMKRLIQ
LGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVG
YRLGQGSTLDAQTAARTGLMVGVCMATLTAIFTVSLREQIALLYNDNPEVVTLAAHLMLL
AAVYQISDSIQVIGSGILRGYKDTRSIFYITFTAYWVLGLPSGYILALTDLVVEPMGPAG
FWIGFIIGLTSAAIMMMLRMRFLQRLPSAIILQRASR
Number of residues
457
Molecular Weight
49446.52
Theoretical pI
Not Available
GO Classification
Functions
antiporter activity / drug transmembrane transporter activity
Processes
sodium ion transport
Components
integral component of membrane / plasma membrane
General Function
Drug transmembrane transporter activity
Specific Function
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
Pfam Domain Function
Transmembrane Regions
11-31 53-73 93-113 127-147 160-180 189-209 243-263 276-296 314-334 350-370 387-407 418-438
Cellular Location
Cell inner membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDC3T8E2
UniProtKB Entry NameC3T8E2_ECOLX
General References
  1. Leopold SR, Magrini V, Holt NJ, Shaikh N, Mardis ER, Cagno J, Ogura Y, Iguchi A, Hayashi T, Mellmann A, Karch H, Besser TE, Sawyer SA, Whittam TS, Tarr PI: A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8713-8. doi: 10.1073/pnas.0812949106. Epub 2009 May 13. [Article]
  2. Mercer RG, Zheng J, Garcia-Hernandez R, Ruan L, Ganzle MG, McMullen LM: Genetic determinants of heat resistance in Escherichia coli. Front Microbiol. 2015 Sep 9;6:932. doi: 10.3389/fmicb.2015.00932. eCollection 2015. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00537Ciprofloxacinapproved, investigationalunknownDetails