Pyridoxal 5'-phosphate synthase subunit Pdx1

Details

Name
Pyridoxal 5'-phosphate synthase subunit Pdx1
Synonyms
  • 4.3.3.6
  • PLP synthase subunit Pdx1
Gene Name
pdx1
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0051544|Pyridoxal 5'-phosphate synthase subunit Pdx1
MENHKDDAVLLKHGWCEMLKGGVIMDVKSVEQAKIAEEAGAIGVMVLENIPSELRNKEGV
ARSVDPSKVEEIKKCVSINVLAKVRIGHFVEAQILEELKIDMIDESEVLTIADEMHHIDK
HKFKTPFVCGCTNLGEALRRISEGASMIRTKGEAGTGNIIEAIKHIRTVNNEIKYLCSLS
DSEVYHFAKKINAPIDLVLLTKKLKRLPVVNFAAGGVATPADAAMCMQLGMDGVFVGSGI
FESENPRKMAASIVSAVSNFNNPKILLDVSMNLGKAMCGSTRVSDKWKNKNEEHTKFLTP
Q
Number of residues
301
Molecular Weight
33013.16
Theoretical pI
Not Available
GO Classification
Functions
catalytic activity / glutaminase activity / identical protein binding / pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Processes
pyridoxal phosphate biosynthetic process / pyridoxine biosynthetic process / response to singlet oxygen / vitamin B6 biosynthetic process
Components
cytosol
General Function
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Specific Function
Catalytic activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051545|Pyridoxal 5'-phosphate synthase subunit Pdx1 (pdx1)
ATGGAAAATCATAAAGATGATGCAGTTTTATTAAAACACGGATGGTGCGAAATGCTTAAA
GGAGGAGTTATTATGGATGTAAAAAGTGTAGAACAAGCAAAGATAGCTGAAGAAGCTGGA
GCTATTGGTGTAATGGTTTTAGAAAACATTCCTTCTGAGCTTAGGAATAAGGAAGGTGTT
GCAAGAAGTGTAGATCCATCAAAAGTAGAAGAGATAAAGAAATGCGTTTCTATTAATGTT
CTTGCTAAAGTTCGTATTGGTCATTTTGTTGAAGCACAAATTTTAGAAGAGCTTAAAATT
GATATGATAGATGAAAGCGAAGTATTAACAATTGCTGATGAAATGCATCATATTGATAAG
CATAAATTTAAAACTCCTTTTGTATGTGGGTGTACAAATTTAGGAGAAGCTCTAAGAAGA
ATATCTGAAGGAGCTTCTATGATAAGAACTAAAGGAGAAGCTGGTACAGGTAATATTATA
GAAGCTATTAAACATATAAGAACTGTAAATAATGAAATCAAATATTTATGTTCTTTAAGC
GATAGTGAAGTCTATCATTTTGCTAAAAAAATTAATGCACCTATCGATCTTGTTTTACTT
ACAAAAAAATTAAAAAGATTACCAGTTGTTAATTTTGCTGCTGGAGGTGTTGCTACTCCA
GCTGATGCAGCCATGTGTATGCAATTAGGAATGGATGGAGTTTTTGTAGGGTCAGGTATT
TTCGAAAGTGAAAACCCAAGAAAAATGGCAGCTTCAATCGTTTCAGCTGTTAGCAATTTT
AATAACCCTAAAATACTTTTAGATGTTAGTATGAATTTAGGAAAAGCCATGTGTGGAAGC
ACACGCGTTTCGGATAAATGGAAAAATAAAAATGAAGAACACACCAAATTTTTAACACCA
CAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDC6KT50
UniProtKB Entry NamePDX1_PLAF7
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
  2. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
  3. Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Muller S, Macheroux P, Tews I, Kappes B: Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. J Biol Chem. 2006 Feb 10;281(6):3633-41. doi: 10.1074/jbc.M508696200. Epub 2005 Dec 8. [Article]
  4. Muller IB, Knockel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C: The assembly of the plasmodial PLP synthase complex follows a defined course. PLoS One. 2008 Mar 19;3(3):e1815. doi: 10.1371/journal.pone.0001815. [Article]
  5. Guedez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Bottcher B, Sinning I, Kappes B, Tews I: Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme. Structure. 2012 Jan 11;20(1):172-84. doi: 10.1016/j.str.2011.11.015. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails