Pyridoxal 5'-phosphate synthase subunit Pdx1
Details
- Name
- Pyridoxal 5'-phosphate synthase subunit Pdx1
- Synonyms
- 4.3.3.6
- PLP synthase subunit Pdx1
- Gene Name
- pdx1
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0051544|Pyridoxal 5'-phosphate synthase subunit Pdx1 MENHKDDAVLLKHGWCEMLKGGVIMDVKSVEQAKIAEEAGAIGVMVLENIPSELRNKEGV ARSVDPSKVEEIKKCVSINVLAKVRIGHFVEAQILEELKIDMIDESEVLTIADEMHHIDK HKFKTPFVCGCTNLGEALRRISEGASMIRTKGEAGTGNIIEAIKHIRTVNNEIKYLCSLS DSEVYHFAKKINAPIDLVLLTKKLKRLPVVNFAAGGVATPADAAMCMQLGMDGVFVGSGI FESENPRKMAASIVSAVSNFNNPKILLDVSMNLGKAMCGSTRVSDKWKNKNEEHTKFLTP Q
- Number of residues
- 301
- Molecular Weight
- 33013.16
- Theoretical pI
- Not Available
- GO Classification
- Functionscatalytic activity / glutaminase activity / identical protein binding / pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activityProcessespyridoxal phosphate biosynthetic process / pyridoxine biosynthetic process / response to singlet oxygen / vitamin B6 biosynthetic processComponentscytosol
- General Function
- Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
- Specific Function
- Catalytic activity
- Pfam Domain Function
- SOR_SNZ (PF01680)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051545|Pyridoxal 5'-phosphate synthase subunit Pdx1 (pdx1) ATGGAAAATCATAAAGATGATGCAGTTTTATTAAAACACGGATGGTGCGAAATGCTTAAA GGAGGAGTTATTATGGATGTAAAAAGTGTAGAACAAGCAAAGATAGCTGAAGAAGCTGGA GCTATTGGTGTAATGGTTTTAGAAAACATTCCTTCTGAGCTTAGGAATAAGGAAGGTGTT GCAAGAAGTGTAGATCCATCAAAAGTAGAAGAGATAAAGAAATGCGTTTCTATTAATGTT CTTGCTAAAGTTCGTATTGGTCATTTTGTTGAAGCACAAATTTTAGAAGAGCTTAAAATT GATATGATAGATGAAAGCGAAGTATTAACAATTGCTGATGAAATGCATCATATTGATAAG CATAAATTTAAAACTCCTTTTGTATGTGGGTGTACAAATTTAGGAGAAGCTCTAAGAAGA ATATCTGAAGGAGCTTCTATGATAAGAACTAAAGGAGAAGCTGGTACAGGTAATATTATA GAAGCTATTAAACATATAAGAACTGTAAATAATGAAATCAAATATTTATGTTCTTTAAGC GATAGTGAAGTCTATCATTTTGCTAAAAAAATTAATGCACCTATCGATCTTGTTTTACTT ACAAAAAAATTAAAAAGATTACCAGTTGTTAATTTTGCTGCTGGAGGTGTTGCTACTCCA GCTGATGCAGCCATGTGTATGCAATTAGGAATGGATGGAGTTTTTGTAGGGTCAGGTATT TTCGAAAGTGAAAACCCAAGAAAAATGGCAGCTTCAATCGTTTCAGCTGTTAGCAATTTT AATAACCCTAAAATACTTTTAGATGTTAGTATGAATTTAGGAAAAGCCATGTGTGGAAGC ACACGCGTTTCGGATAAATGGAAAAATAAAAATGAAGAACACACCAAATTTTTAACACCA CAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID C6KT50 UniProtKB Entry Name PDX1_PLAF7 - General References
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
- Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Muller S, Macheroux P, Tews I, Kappes B: Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. J Biol Chem. 2006 Feb 10;281(6):3633-41. doi: 10.1074/jbc.M508696200. Epub 2005 Dec 8. [Article]
- Muller IB, Knockel J, Groves MR, Jordanova R, Ealick SE, Walter RD, Wrenger C: The assembly of the plasmodial PLP synthase complex follows a defined course. PLoS One. 2008 Mar 19;3(3):e1815. doi: 10.1371/journal.pone.0001815. [Article]
- Guedez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Bottcher B, Sinning I, Kappes B, Tews I: Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme. Structure. 2012 Jan 11;20(1):172-84. doi: 10.1016/j.str.2011.11.015. [Article]