Tripartite terminase subunit 3
Details
- Name
- Tripartite terminase subunit 3
- Synonyms
- 3.1.-.-
- Terminase large subunit
- Gene Name
- TRM3
- Organism
- Human Cytomegalovirus
- Amino acid sequence
>lcl|BSEQ0051324|Tripartite terminase subunit 3 MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVAALCRKRYQMMHPELGLAHSCNEAF LPLMAFCGRHRDYNSPEESQRELLFHERLKSALDELTFRPCSEEQRASYQKLDALTELYR DPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIFFIAVTKIPVLAN RVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISFLLKHMIGISIGY VAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTALFASCYNTNSIRG QNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDATCFLTRLNNAPFDML NVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFMPGAFMDEIIGGT NKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTTNRKASGTGVAAV GAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDELRIAVEGNTNQA AAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVEQFISRFNSGYIK ASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRISDDLIIAVIMAT YLCDDIHAIRFRVS
- Number of residues
- 674
- Molecular Weight
- 77033.575
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA binding / hydrolase activityProcessesDNA packaging / viral release from host cellComponentshost cell nucleus
- General Function
- Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
- Specific Function
- Dna binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Gene sequence
>lcl|BSEQ0051325|Tripartite terminase subunit 3 (TRM3) ATGTTGCGCGGAGATTCGGCCGCCAAGATCCAGGAGCGCTACGCGGAGCTGCAGAAGCGC AAGAGCCACCCCACCTCCTGCATCTCCACGGCCTTCACCAATGTGGCGGCGCTGTGCCGC AAGCGCTACCAGATGATGCACCCCGAACTCGGGCTGGCCCACTCGTGCAACGAGGCCTTC CTGCCGCTCATGGCCTTCTGCGGCCGCCACCGCGACTACAACTCGCCCGAGGAAAGCCAG CGCGAGCTGCTGTTTCACGAGCGCCTCAAGAGTGCGCTCGATGAACTGACGTTTCGCCCG TGCTCCGAGGAGCAGCGCGCCTCCTACCAGAAGCTGGACGCGTTGACCGAGCTCTACCGC GATCCGCAGTTTCAGCAGATCAACAACTTCATGACCGACTTTAAAAAGTGGCTCGACGGC GGCTTCAGTACCGCCGTCGAGGGCGACGCAAAAGCCATCCGACTCGAACCGTTTCAAAAG AATTTATTGATACACGTCATCTTTTTTATAGCCGTGACCAAGATCCCCGTGCTGGCCAAT CGCGTGCTGCAGTACCTCATCCACGCCTTCCAGATCGACTTCCTCTCGCAGACCTCCATC GACATCTTTAAGCAGAAAGCCACCGTGTTCCTGGTGCCGCGACGTCACGGCAAGACTTGG TTCATCATCCCCATTATCTCGTTTCTGCTTAAGCACATGATCGGCATCAGCATCGGCTAC GTGGCGCACCAAAAGCACGTGTCGCAGTTTGTGCTCAAAGAGGTCGAGTTCCGCTGCCGC CACACCTTCGCGCGCGACTACGTGGTCGAGAACAAGGACAACGTGATCAGCATCGACCAC CGCGGCGCCAAGAGCACGGCGCTTTTTGCCAGTTGCTACAACACCAACAGCATCCGAGGA CAAAACTTCCATTTGCTGCTGGTGGACGAGGCGCACTTCATCAAGAAAGAGGCCTTCAAC ACCATTCTGGGGTTCCTGGCCCAGAATACCACCAAGATCATCTTCATATCGTCCACCAAC ACTACCAGTGACGCCACGTGTTTCTTGACGCGCCTCAACAATGCGCCCTTTGACATGCTC AACGTGGTCTCTTACGTGTGCGAAGAGCACCTGCACAGCTTCACGGAGAAGGGCGACGCC ACGGCGTGTCCTTGCTACCGACTGCACAAGCCCACCTTCATCAGCCTCAACTCGCAGGTG CGCAAGACGGCCAACATGTTTATGCCGGGCGCTTTCATGGACGAGATCATCGGCGGTACC AATAAAATCTCGCAGAACACCGTGCTCATCACGGACCAGAGCCGCGAAGAGTTCGATATT TTGCGTTACAGCACGCTCAACACCAACGCCTACGATTATTTCGGCAAGACGCTTTACGTG TATCTGGACCCGGCCTTCACCACCAACCGCAAGGCCTCGGGCACGGGCGTGGCGGCCGTA GGCGCCTACCGACACCAGTTTCTCATTTACGGCCTAGAGCATTTCTTTTTGCGCGACCTC TCCGAGAGTTCTGAGGTAGCCATCGCCGAGTGCGCGGCGCACATGATCATCTCGGTGCTG AGCCTGCACCCTTACCTGGACGAACTGCGTATCGCCGTGGAGGGCAACACCAACCAGGCG GCGGCCGTGCGCATCGCCTGCCTCATCCGACAGAGCGTGCAGAGCAGCACGCTCATCCGC GTGCTCTTCTACCACACGCCCGACCAGAACCACATCGAACAGCCCTTCTACCTCATGGGC CGCGACAAGGCGCTGGCCGTGGAACAGTTCATCTCGCGTTTCAACTCGGGCTACATCAAA GCCTCGCAAGAGCTCGTCTCCTACACCATCAAGCTGAGCCACGACCCCATCGAGTATCTT CTGGAGCAGATTCAGAACCTGCACCGCGTCACGCTGGCCGAAGGCACGACGGCACGCTAC TCGGCCAAGCGCCAGAATCGTATCTCGGACGATCTTATCATCGCCGTCATCATGGCCACC TACCTGTGTGACGATATACACGCCATCCGTTTCAGGGTCAGCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID F5HCU8 UniProtKB Entry Name TRM3_HCMVM - General References
- Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ: Genetic content of wild-type human cytomegalovirus. J Gen Virol. 2004 May;85(Pt 5):1301-12. [Article]