NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Details
- Name
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
- Synonyms
- 1.6.5.3
- CI-23kD
- Complex I-23kD
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- TYKY subunit
- Gene Name
- NDUFS8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009891|NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLL WTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAI CPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE LLYNKEKLLNNGDKWEAEIAANIQADYLYR
- Number of residues
- 210
- Molecular Weight
- 23704.795
- Theoretical pI
- 6.27
- GO Classification
- Functions4 iron, 4 sulfur cluster binding / metal ion binding / NADH dehydrogenase (ubiquinone) activityProcessescellular metabolic process / mitochondrial electron transport, NADH to ubiquinone / mitochondrial respiratory chain complex I assembly / respiratory electron transport chain / response to oxidative stress / small molecule metabolic processComponentsmitochondrial matrix / mitochondrial respiratory chain complex I / mitochondrion
- General Function
- Nadh dehydrogenase (ubiquinone) activity
- Specific Function
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
- Pfam Domain Function
- Fer4_7 (PF12838)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0009892|NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (NDUFS8) ATGCGCTGCCTGACCACGCCTATGCTGCTGCGGGCCCTGGCCCAGGCTGCACGTGCAGGA CCTCCTGGTGGCCGGAGCCTCCACAGCAGTGCAGTGGCAGCCACCTACAAGTATGTGAAC ATGCAGGATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTG TGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCC ACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCG CTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATC TGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACC ACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGT CCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAG CTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCC GCCAACATCCAGGCTGACTACTTGTATCGGTGA
- Chromosome Location
- 11
- Locus
- 11q13
- External Identifiers
Resource Link UniProtKB ID O00217 UniProtKB Entry Name NDUS8_HUMAN GenBank Protein ID 1935056 GenBank Gene ID U65579 GenAtlas ID NDUFS8 HGNC ID HGNC:7715 - General References
- Procaccio V, Depetris D, Soularue P, Mattei MG, Lunardi J, Issartel JP: cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I. Biochim Biophys Acta. 1997 Mar 20;1351(1-2):37-41. [Article]
- de Sury R, Martinez P, Procaccio V, Lunardi J, Issartel JP: Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase. Gene. 1998 Jul 17;215(1):1-10. [Article]
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