UDP-galactopyranose mutase

Details

Name
UDP-galactopyranose mutase
Synonyms
  • 5.4.99.9
  • UDP-GALP mutase
  • UGM
  • Uridine 5-diphosphate galactopyranose mutase
Gene Name
glf
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051197|UDP-galactopyranose mutase
MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVH
KYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPE
QARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELPAANITR
LPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIEVRLNTDWFDVRGQLRPGSPAAP
VVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQGTAVMNYNDLDVPYTRIHEFRHFH
PERDYPTDKTVIMREYSRFAEDDDEPYYPINTEADRALLATYRARAKSETASSKVLFGGR
LGTYQYLDMHMAIASALNMYDNVLAPHLRDGVPLLQDGA
Number of residues
399
Molecular Weight
45814.07
Theoretical pI
Not Available
GO Classification
Functions
UDP-galactopyranose mutase activity
Processes
Actinobacterium-type cell wall biogenesis / capsule polysaccharide biosynthetic process / cell wall organization
Components
cell wall / plasma membrane
General Function
Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a key building block for cell wall construction in Mycobacterium tuberculosis.
Specific Function
Udp-galactopyranose mutase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051198|UDP-galactopyranose mutase (glf)
ATGCAACCGATGACCGCTCGTTTTGACCTTTTCGTCGTCGGCTCAGGATTCTTCGGCCTG
ACGATTGCCGAGCGCGTGGCCACCCAACTCGACAAGCGCGTGCTCGTCCTCGAGCGGCGC
CCGCACATCGGGGGCAATGCCTATTCCGAAGCCGAGCCACAGACCGGCATCGAGGTCCAC
AAGTACGGTGCGCACCTGTTTCACACCTCTAATAAGAGAGTGTGGGACTACGTGCGGCAG
TTCACCGACTTCACCGACTACCGGCACCGGGTCTTCGCGATGCACAACGGGCAGGCATAT
CAGTTTCCGATGGGGCTCGGCCTGGTATCGCAGTTCTTCGGCAAGTACTTCACGCCCGAG
CAAGCCCGCCAGCTGATCGCCGAGCAGGCCGCCGAGATCGACACCGCCGACGCGCAGAAC
CTCGAGGAGAAGGCCATCTCGCTGATCGGCCGGCCGCTCTACGAAGCGTTCGTCAAGGGG
TACACGGCCAAGCAATGGCAGACTGACCCCAAAGAACTTCCGGCCGCCAACATCACGCGG
CTTCCCGTGCGCTACACCTTCGACAACCGGTATTTCAGCGATACTTACGAGGGTTTGCCG
ACCGACGGGTACACGGCGTGGTTGCAAAACATGGCCGCTGACCACCGCATCGAGGTCAGG
CTGAACACCGACTGGTTCGACGTGCGCGGCCAGCTGCGCCCCGGCAGCCCGGCGGCCCCG
GTCGTTTACACCGGCCCGCTGGACCGCTACTTCGACTACGCCGAAGGCCGATTGGGCTGG
CGCACCTTGGACTTCGAGGTGGAAGTGCTACCGATCGGGGACTTTCAGGGCACCGCGGTG
ATGAACTACAACGATCTCGACGTCCCCTACACGCGCATCCACGAGTTCCGCCACTTCCAC
CCCGAGCGTGACTACCCAACGGACAAAACGGTGATCATGCGGGAATACTCCCGGTTCGCC
GAGGACGACGACGAGCCATACTATCCGATCAACACCGAGGCTGACCGCGCCCTGTTGGCC
ACCTATCGGGCCAGGGCGAAGTCCGAGACCGCGTCATCGAAGGTACTGTTCGGCGGCCGG
TTGGGCACCTACCAATATCTGGATATGCATATGGCCATTGCCAGCGCCTTGAACATGTAC
GACAACGTCCTCGCGCCGCATCTGCGCGACGGCGTCCCACTGCTTCAGGACGGCGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WIQ1
UniProtKB Entry NameGLF_MYCTU
General References
  1. Weston A, Stern RJ, Lee RE, Nassau PM, Monsey D, Martin SL, Scherman MS, Besra GS, Duncan K, McNeil MR: Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues. Tuber Lung Dis. 1997;78(2):123-31. [Article]
  2. Chen P, Bishai WR: Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance. Infect Immun. 1998 Nov;66(11):5099-106. [Article]
  3. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH: Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol. 2005 May 13;348(4):971-82. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails
DB03709BicineexperimentalunknownDetails