Calsequestrin-2
Details
- Name
- Calsequestrin-2
- Synonyms
- Calsequestrin, cardiac muscle isoform
- Gene Name
- CASQ2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049484|Calsequestrin-2 MKRTHLFIVGIYFLSSCRAEEGLNFPTYDGKDRVVSLSEKNFKQVLKKYDLLCLYYHEPV SSDKVTQKQFQLKEIVLELVAQVLEHKAIGFVMVDAKKEAKLAKKLGFDEEGSLYILKGD RTIEFDGEFAADVLVEFLLDLIEDPVEIISSKLEVQAFERIEDYIKLIGFFKSEDSEYYK AFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVDFYEPFMDEPIAIPNKPYTEEELVEF VKEHQRPTLRRLRPEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPD LSILWIDPDDFPLLVAYWEKTFKIDLFRPQIGVVNVTDADSVWMEIPDDDDLPTAEELED WIEDVLSGKINTEDDDEDDDDDDNSDEEDNDDSDDDDDE
- Number of residues
- 399
- Molecular Weight
- 46435.28
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion binding / calcium-dependent protein binding / protein homodimerization activityProcessescardiac muscle contraction / cellular response to caffeine / detection of calcium ion / ion transmembrane transport / negative regulation of potassium ion transmembrane transporter activity / negative regulation of potassium ion transport / negative regulation of ryanodine-sensitive calcium-release channel activity / protein polymerization / Purkinje myocyte to ventricular cardiac muscle cell signaling / regulation of cardiac conduction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of cell communication by electrical coupling / regulation of heart rate / regulation of membrane repolarization / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / sarcomere organization / sequestering of calcium ion / striated muscle contractionComponentscalcium channel complex / cytoplasm / intracellular / junctional membrane complex / junctional sarcoplasmic reticulum membrane / sarcoplasmic reticulum / sarcoplasmic reticulum lumen / sarcoplasmic reticulum membrane / Z disc
- General Function
- Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
- Specific Function
- Calcium ion binding
- Pfam Domain Function
- Calsequestrin (PF01216)
- Transmembrane Regions
- Not Available
- Cellular Location
- Sarcoplasmic reticulum lumen
- Gene sequence
>lcl|BSEQ0049485|Calsequestrin-2 (CASQ2) ATGAAGAGAACTCACTTGTTTATTGTGGGGATTTATTTTCTGTCCTCTTGCAGGGCAGAA GAGGGGCTTAATTTCCCCACATATGATGGGAAGGACCGAGTGGTAAGTCTTTCCGAGAAG AACTTCAAGCAGGTTTTAAAGAAATATGACTTGCTTTGCCTCTACTACCATGAGCCGGTG TCTTCAGATAAGGTCACGCAAAAACAGTTCCAACTGAAAGAAATCGTGCTTGAGCTTGTG GCCCAGGTCCTTGAACATAAAGCTATAGGCTTTGTGATGGTGGATGCCAAGAAAGAAGCC AAGCTTGCCAAGAAACTGGGTTTTGATGAAGAAGGAAGCCTGTATATTCTTAAGGGTGAT CGCACAATAGAGTTTGATGGCGAGTTTGCAGCTGATGTCTTGGTGGAGTTCCTCTTGGAT CTAATTGAAGACCCAGTGGAGATCATCAGCAGCAAACTGGAAGTCCAAGCCTTCGAACGC ATTGAAGACTACATCAAACTCATTGGCTTTTTCAAGAGTGAGGACTCAGAATACTACAAG GCTTTTGAAGAAGCAGCTGAACACTTCCAGCCTTACATCAAATTCTTTGCCACCTTTGAC AAAGGGGTTGCAAAGAAATTATCTTTGAAGATGAATGAGGTTGACTTCTATGAGCCATTT ATGGATGAGCCCATTGCCATCCCCAACAAACCTTACACAGAAGAGGAGCTGGTGGAGTTT GTGAAGGAACACCAAAGACCCACTCTACGTCGCCTGCGCCCAGAAGAAATGTTTGAAACA TGGGAAGATGATTTGAATGGGATCCACATTGTGGCCTTTGCAGAGAAGAGTGATCCAGAT GGCTACGAATTCCTGGAGATCCTGAAACAGGTTGCCCGGGACAATACTGACAACCCCGAT CTGAGCATCCTGTGGATCGACCCGGACGACTTTCCTCTGCTCGTTGCCTACTGGGAGAAG ACTTTCAAGATTGACCTATTCAGGCCACAGATTGGGGTGGTGAATGTCACAGATGCTGAC AGTGTCTGGATGGAGATTCCAGATGATGACGATCTTCCAACTGCTGAGGAGCTGGAGGAC TGGATTGAGGATGTGCTTTCTGGAAAGATAAACACTGAAGATGATGATGAAGATGATGAT GATGATGATAATTCTGATGAAGAGGATAATGATGACAGTGATGACGATGATGATGAATAG
- Chromosome Location
- 1
- Locus
- 1p13.1
- External Identifiers
Resource Link UniProtKB ID O14958 UniProtKB Entry Name CASQ2_HUMAN HGNC ID HGNC:1513 - General References
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