Peptidoglycan-N-acetylmuramic acid deacetylase PdaA

Details

Name
Peptidoglycan-N-acetylmuramic acid deacetylase PdaA
Synonyms
  • 3.5.1.-
  • Peptidoglycan MurNAc deacetylase
  • yfjS
Gene Name
pdaA
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0011434|Peptidoglycan-N-acetylmuramic acid deacetylase PdaA
MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDAGKQLNSLIEKYDAFYL
GNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGHFVKDQPQLIKRMSDEGHI
IGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNLYLRPPRGVFSEYVLKETKRL
GYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAIYLLHTVSRDNAEALDDAITDLK
KQGYTFKSIDDLMFEKEMRLPSL
Number of residues
263
Molecular Weight
30069.06
Theoretical pI
7.7
GO Classification
Functions
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds / metal ion binding
Processes
carbohydrate metabolic process / cell wall organization / sporulation resulting in formation of a cellular spore
General Function
Metal ion binding
Specific Function
Catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in glycan strands of peptidoglycan, leading to the formation of muramic delta-lactam residues in spore cortex, after transpeptidation of deacetylated muramic acid residues. PdaA probably carries out both deacetylation and lactam ring formation and requires the product of CwlD activity on peptidoglycan as a substrate. Is required for germination. Cannot use chitin oligomer (hexa-N-acetylchitohexaose) as a substrate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011435|Peptidoglycan-N-acetylmuramic acid deacetylase PdaA (pdaA)
ATGAAGTGGATGTGTTCAATATGCTGCGCCGCCGTATTGCTTGCCGGAGGTGCAGCACAG
GCGGAAGCGGTGCCGAATGAGCCGATTAATTGGGGCTTTAAACGAAGTGTCAATCATCAG
CCGCCAGATGCCGGGAAGCAGCTGAACAGTTTAATTGAAAAATATGACGCGTTTTATTTA
GGGAATACAAAGGAAAAAACGATTTACTTAACGTTTGATAACGGATATGAAAATGGCTAT
ACGCCAAAAGTGCTTGATGTCTTAAAAAAACATCGCGTAACAGGAACGTTTTTTGTCACC
GGGCATTTCGTAAAGGACCAGCCTCAGCTGATCAAACGAATGTCAGATGAGGGCCATATT
ATCGGCAATCATTCCTTTCACCATCCGGATTTAACGACAAAAACAGCTGATCAGATTCAG
GATGAACTTGATTCAGTCAACGAAGAGGTTTATAAAATTACGGGAAAGCAGGACAACCTG
TATTTGCGTCCGCCGCGCGGCGTGTTCAGTGAGTACGTACTGAAAGAAACGAAACGCCTC
GGCTATCAAACCGTTTTCTGGTCGGTCGCTTTTGTTGATTGGAAAATCAACAACCAAAAG
GGAAAGAAATATGCCTACGATCATATGATCAAGCAGGCGCACCCGGGAGCCATTTACCTG
CTTCACACCGTATCGAGGGACAATGCAGAAGCGCTGGATGACGCGATTACAGATCTGAAA
AAACAGGGCTACACTTTTAAAAGCATTGATGATCTGATGTTTGAGAAAGAAATGAGGCTG
CCGTCTTTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO34928
UniProtKB Entry NamePDAA_BACSU
GenBank Protein ID2626811
GenBank Gene IDD83967
General References
  1. Yamamoto H, Uchiyama S, Sekiguchi J: Cloning and sequencing of a 40.6 kb segment in the 73 degrees-76 degrees region of the Bacillus subtilis chromosome containing genes for trehalose metabolism and acetoin utilization. Microbiology. 1996 Nov;142 ( Pt 11):3057-65. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Fukushima T, Yamamoto H, Atrih A, Foster SJ, Sekiguchi J: A polysaccharide deacetylase gene (pdaA) is required for germination and for production of muramic delta-lactam residues in the spore cortex of Bacillus subtilis. J Bacteriol. 2002 Nov;184(21):6007-15. [Article]
  4. Gilmore ME, Bandyopadhyay D, Dean AM, Linnstaedt SD, Popham DL: Production of muramic delta-lactam in Bacillus subtilis spore peptidoglycan. J Bacteriol. 2004 Jan;186(1):80-9. [Article]
  5. Fukushima T, Kitajima T, Sekiguchi J: A polysaccharide deacetylase homologue, PdaA, in Bacillus subtilis acts as an N-acetylmuramic acid deacetylase in vitro. J Bacteriol. 2005 Feb;187(4):1287-92. [Article]
  6. Blair DE, van Aalten DM: Structures of Bacillus subtilis PdaA, a family 4 carbohydrate esterase, and a complex with N-acetyl-glucosamine. FEBS Lett. 2004 Jul 16;570(1-3):13-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03740N-acetyl-alpha-D-glucosamineexperimentalunknownDetails