Cytochrome P450 26A1
Details
- Name
- Cytochrome P450 26A1
- Synonyms
- 1.14.-.-
- CYP26
- Cytochrome P450 retinoic acid-inactivating 1
- Cytochrome P450RAI
- hP450RAI
- P450RAI1
- Retinoic acid 4-hydroxylase
- Retinoic acid-metabolizing cytochrome
- Gene Name
- CYP26A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037239|Cytochrome P450 26A1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV YPVDNLPARFTHFHGEI
- Number of residues
- 497
- Molecular Weight
- 56198.11
- Theoretical pI
- 8.73
- GO Classification
- Functionsheme binding / iron ion binding / oxygen binding / retinoic acid 4-hydroxylase activity / retinoic acid bindingProcessesmetabolic process / negative regulation of retinoic acid receptor signaling pathway / retinoic acid catabolic process / small molecule metabolic process / vitamin metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum membrane
- General Function
- Retinoic acid binding
- Specific Function
- Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0017113|Cytochrome P450 26A1 (CYP26A1) ATGGGGCTCCCGGCGCTGCTGGCCAGTGCGCTCTGCACCTTCGTGCTGCCGCTGCTGCTC TTCCTGGCTGCGATCAAGCTCTGGGACCTGTACTGCGTGAGCGGCCGCGACCGCAGTTGT GCCCTCCCATTGCCCCCCGGGACTATGGGCTTCCCCTTCTTTGGGGAAACCTTGCAGATG GTACTGCAGCGGAGGAAGTTCCTGCAGATGAAGCGCAGGAAATACGGCTTCATCTACAAG ACGCATCTGTTCGGGCGGCCCACCGTACGGGTGATGGGCGCGGACAATGTGCGGCGCATC TTGCTCGGAGAGCACCGGCTGGTGTCGGTCCACTGGCCAGCGTCGGTGCGCACCATTCTG GGATCTGGCTGCCTCTCTAACCTGCACGACTCCTCGCACAAGCAGCGCAAGAAGGTGATT ATGCGGGCCTTCAGCCGCGAGGCACTCGAATGCTACGTGCCGGTGATCACCGAGGAAGTG GGCAGCAGCCTGGAGCAGTGGCTGAGCTGCGGCGAGCGCGGCCTCCTGGTCTACCCCGAG GTGAAGCGCCTCATGTTCCGAATCGCCATGCGCATCCTACTGGGCTGCGAACCCCAACTG GCGGGCGACGGGGACTCCGAGCAGCAGCTTGTGGAGGCCTTCGAGGAAATGACCCGCAAT CTCTTCTCGCTGCCCATCGACGTGCCCTTCAGCGGGCTGTACCGGGGCATGAAGGCGCGG AACCTCATTCACGCGCGCATCGAGCAGAACATTCGCGCCAAGATCTGCGGGCTGCGGGCA TCCGAGGCGGGCCAGGGCTGCAAAGACGCGCTGCAGCTGTTGATCGAGCACTCGTGGGAG AGGGGAGAGCGGCTGGACATGCAGGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGA GGACACGAAACCACGGCCAGTGCAGCCACATCTCTGATCACTTACCTGGGGCTCTACCCA CATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAAT CAAGACAACAAGTTGGACATGGAAATTTTGGAACAACTTAAATACATCGGGTGTGTTATT AAGGAGACCCTTCGACTGAATCCCCCAGTTCCAGGAGGGTTTCGGGTTGCTCTGAAGACT TTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGAT ACTCATGATGTGGCAGAGATCTTCACCAACAAGGAAGAATTTAATCCTGACCGATTCATG CTGCCTCACCCAGAGGATGCATCCAGGTTCAGCTTCATTCCATTTGGAGGAGGCCTTAGG AGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCC AGGCATTGTGACTGGCAGCTTCTAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTG TATCCTGTGGACAATCTCCCTGCAAGATTCACCCATTTCCATGGGGAAATCTGA
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O43174 UniProtKB Entry Name CP26A_HUMAN GenBank Gene ID AF005418 GenAtlas ID CYP26A1 HGNC ID HGNC:2603 - General References
- White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M: cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem. 1997 Jul 25;272(30):18538-41. [Article]
- Sonneveld E, van den Brink CE, van der Leede BM, Schulkes RK, Petkovich M, van der Burg B, van der Saag PT: Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. Cell Growth Differ. 1998 Aug;9(8):629-37. [Article]
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