Trafficking protein particle complex subunit 3

Details

Name
Trafficking protein particle complex subunit 3
Synonyms
  • BET3
  • BET3 homolog
Gene Name
TRAPPC3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006207|Trafficking protein particle complex subunit 3
MSRQANRGTESKKMSSELFTLTYGALVTQLCKDYENDEDVNKQLDKMGFNIGVRLIEDFL
ARSNVGRCHDFRETADVIAKVAFKMYLGITPSITNWSPAGDEFSLILENNPLVDFVELPD
NHSSLIYSNLLCGVLRGALEMVQMAVEAKFVQDTLKGDGVTEIRMRFIRRIEDNLPAGEE
Number of residues
180
Molecular Weight
20273.915
Theoretical pI
4.58
GO Classification
Processes
cellular protein metabolic process / COPII vesicle coating / ER to Golgi vesicle-mediated transport / membrane organization / post-translational protein modification / protein N-linked glycosylation via asparagine
Components
cytoplasm / cytosol / endoplasmic reticulum / Golgi apparatus / Golgi membrane
General Function
Not Available
Specific Function
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Golgi apparatus
Gene sequence
>lcl|BSEQ0021349|Trafficking protein particle complex subunit 3 (TRAPPC3)
ATGTCGAGGCAGGCGAACCGTGGCACCGAGAGCAAGAAAATGAGCTCTGAGCTCTTCACC
CTGACCTATGGTGCCCTGGTCACCCAGCTATGTAAGGACTATGAAAATGATGAAGATGTG
AATAAACAGCTGGACAAAATTCTCTTCTCTAACTTCCTTCCCAGGGGCTTTAACATTGGA
GTCCGGCTGATTGAAGATTTCTTGGCTCGGTCAAATGTTGGGAGGTGCCATGACTTTCGG
GAAACTGCGGATGTCATTGCCAAGGTGGCGTTCAAGATGTACTTGGGCATCACTCCAAGC
ATTACTAATTGGAGCCCAGCTGGTGATGAATTCTCCCTCATTTTGGAAAATAACCCCTTG
GTGGACTTTGTGGAACTTCCTGATAACCACTCATCCCTTATTTATTCCAATCTCTTGTGT
GGGGTGTTGCGGGGAGCTTTGGAGATGGTCCAGATGGCTGTGGAGGCCAAGTTTGTCCAG
GACACCCTGAAAGGAGACGGTGTGACAGAAATCCGGATGAGATTCATCAGGCGGATTGAG
GACAATCTTCCAGCTGGAGAGGAATAA
Chromosome Location
1
Locus
1p34.3
External Identifiers
ResourceLink
UniProtKB IDO43617
UniProtKB Entry NameTPPC3_HUMAN
GenBank Gene IDAJ224335
GenAtlas IDTRAPPC3
HGNC IDHGNC:19942
General References
  1. Sacher M, Jiang Y, Barrowman J, Scarpa A, Burston J, Zhang L, Schieltz D, Yates JR 3rd, Abeliovich H, Ferro-Novick S: TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J. 1998 May 1;17(9):2494-503. [Article]
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  5. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G: Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7. [Article]
  6. Scrivens PJ, Shahrzad N, Moores A, Morin A, Brunet S, Sacher M: TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. Traffic. 2009 Jun;10(6):724-36. doi: 10.1111/j.1600-0854.2009.00906.x. Epub 2009 Mar 3. [Article]
  7. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  8. Scrivens PJ, Noueihed B, Shahrzad N, Hul S, Brunet S, Sacher M: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Mol Biol Cell. 2011 Jun 15;22(12):2083-93. doi: 10.1091/mbc.E10-11-0873. Epub 2011 Apr 27. [Article]
  9. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  10. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  11. Turnbull AP, Kummel D, Prinz B, Holz C, Schultchen J, Lang C, Niesen FH, Hofmann KP, Delbruck H, Behlke J, Muller EC, Jarosch E, Sommer T, Heinemann U: Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization. EMBO J. 2005 Mar 9;24(5):875-84. Epub 2005 Feb 3. [Article]
  12. Kim MS, Yi MJ, Lee KH, Wagner J, Munger C, Kim YG, Whiteway M, Cygler M, Oh BH, Sacher M: Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. Traffic. 2005 Dec;6(12):1183-95. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03796Palmitic AcidapprovedunknownDetails
DB08231Myristic acidexperimentalunknownDetails
DB08342S-palmitoyl-L-cysteineexperimentalunknownDetails