Beta-1,4-galactosyltransferase 4
Details
- Name
- Beta-1,4-galactosyltransferase 4
- Synonyms
- 2.4.1.-
- Beta-1,4-GalTase 4
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
- Gene Name
- B4GALT4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011630|Beta-1,4-galactosyltransferase 4 MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKG KTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKA LQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLE ALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSR EQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAE RMKLLHQVSRVWRTDGLSSCSYKLVSVEHNPLYINITVDFWFGA
- Number of residues
- 344
- Molecular Weight
- 40040.865
- Theoretical pI
- 9.42
- GO Classification
- Functionsgalactosyltransferase activity / metal ion binding / N-acetyllactosamine synthase activityProcessescarbohydrate metabolic process / cellular protein metabolic process / glycosaminoglycan metabolic process / keratan sulfate biosynthetic process / keratan sulfate metabolic process / membrane lipid metabolic process / post-translational protein modification / protein N-linked glycosylation via asparagine / small molecule metabolic processComponentsGolgi cisterna membrane / Golgi membrane / integral component of membrane
- General Function
- N-acetyllactosamine synthase activity
- Specific Function
- Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
- Pfam Domain Function
- Transmembrane Regions
- 13-38
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0011631|Beta-1,4-galactosyltransferase 4 (B4GALT4) ATGGGCTTCAACCTGACTTTCCACCTTTCCTACAAATTCCGATTACTGTTGCTGTTGACT TTGTGCCTGACAGTGGTTGGGTGGGCCACCAGTAACTACTTCGTGGGTGCCATTCAAGAG ATTCCTAAAGCAAAGGAGTTCATGGCTAATTTCCATAAGACCCTCATTTTGGGGAAGGGA AAAACTCTGACTAATGAAGCATCCACGAAGAAGGTAGAACTTGACAACTGCCCTTCTGTG TCTCCTTACCTCAGAGGCCAGAGCAAGCTCATTTTCAAACCAGATCTCACTTTGGAAGAG GTACAGGCAGAAAATCCCAAAGTGTCCAGAGGCCGGTATCGCCCTCAGGAATGTAAAGCT TTACAGAGGGTCGCCATCCTCGTTCCCCACCGGAACAGAGAGAAACACCTGATGTACCTG CTGGAACATCTGCATCCCTTCCTGCAGAGGCAGCAGCTGGATTATGGCATCTACGTCATC CACCAGGCTGAAGGTAAAAAGTTTAATCGAGCCAAACTCTTGAATGTGGGCTATCTAGAA GCCCTCAAGGAAGAAAATTGGGACTGCTTTATATTCCACGATGTGGACCTGGTACCCGAG AATGACTTTAACCTTTACAAGTGTGAGGAGCATCCCAAGCATCTGGTGGTTGGCAGGAAC AGCACTGGGTACAGGTTACGTTACAGTGGATATTTTGGGGGTGTTACTGCCCTAAGCAGA GAGCAGTTTTTCAAGGTGAATGGATTCTCTAACAACTACTGGGGATGGGGAGGCGAAGAC GATGACCTCAGACTCAGGGTTGAGCTCCAAAGAATGAAAATTTCCCGGCCCCTGCCTGAA GTGGGTAAATATACAATGGTCTTCCACACTAGAGACAAAGGCAATGAGGTGAACGCAGAA CGGATGAAGCTCTTACACCAAGTGTCACGAGTCTGGAGAACAGATGGGTTGAGTAGTTGT TCTTATAAATTAGTATCTGTGGAACACAATCCTTTATATATCAACATCACAGTGGATTTC TGGTTTGGTGCATGA
- Chromosome Location
- 3
- Locus
- 3q13.3
- External Identifiers
Resource Link UniProtKB ID O60513 UniProtKB Entry Name B4GT4_HUMAN GenBank Protein ID 3132900 GenBank Gene ID AF038662 GenAtlas ID B4GALT4 HGNC ID HGNC:927 - General References
- Lo NW, Shaper JH, Pevsner J, Shaper NL: The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998 May;8(5):517-26. [Article]
- Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H: Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem. 1998 Nov 6;273(45):29331-40. [Article]
- Guo S, Sato T, Shirane K, Furukawa K: Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. Glycobiology. 2001 Oct;11(10):813-20. [Article]
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- Amado M, Almeida R, Schwientek T, Clausen H: Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999 Dec 6;1473(1):35-53. [Article]