NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Details

Name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
Synonyms
  • CI-MNLL
  • Complex I-MNLL
  • NADH-ubiquinone oxidoreductase MNLL subunit
Gene Name
NDUFB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000673|NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
MVNLLQIVRDHWVHVLVPMGFVIGCYLDRKSDERLTAFRNKSMLFKRELQPSEEVTWK
Number of residues
58
Molecular Weight
6961.165
Theoretical pI
9.34
GO Classification
Functions
NADH dehydrogenase (ubiquinone) activity
Processes
cellular metabolic process / mitochondrial electron transport, NADH to ubiquinone / respiratory electron transport chain / small molecule metabolic process
Components
extracellular exosome / integral component of membrane / mitochondrial inner membrane / mitochondrial respiratory chain complex I
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Pfam Domain Function
Transmembrane Regions
11-27
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0016068|NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NDUFB1)
ATGATTTGCTGGCGTCACCCCTCTGCTCCGTGCGGGCGCGGCGAATGGCAGGTCCCGAGG
TCGCAGCTTCCACTGGCGCGGGTTGAGTTCCCTGTTGCCCTTGGTCTCGGGGTCGCTGTA
GGCGCTGAGGCTGCAGCTATCATGGTGAACTTACTTCAGATTGTGCGGGACCACTGGGTT
CATGTTCTTGTCCCTATGGGATTTGTCATTGGATGTTATTTAGACAGAAAGAGTGATGAA
CGGCTAACTGCCTTCCGGAACAAGAGTATGTTATTTAAAAGGGAATTGCAACCCAGTGAA
GAAGTTACCTGGAAGTAA
Chromosome Location
14
Locus
14q32.12
External Identifiers
ResourceLink
UniProtKB IDO75438
UniProtKB Entry NameNDUB1_HUMAN
GenBank Protein ID5326820
GenBank Gene IDAF050638
GenAtlas IDNDUFB1
HGNC IDHGNC:7695
General References
  1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8175-80. [Article]
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  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00157NADHapproved, nutraceuticalunknownDetails