Serine/threonine-protein kinase 16
Details
- Name
- Serine/threonine-protein kinase 16
- Synonyms
- 2.7.11.1
- hPSK
- MPSK
- MPSK1
- Myristoylated and palmitoylated serine/threonine-protein kinase
- PKL12
- Protein kinase PKL12
- TGF-beta-stimulated factor 1
- TSF-1
- TSF1
- Tyrosine-protein kinase STK16
- Gene Name
- STK16
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051961|Serine/threonine-protein kinase 16 MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE EAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGS RQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ KGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQ HTTQI
- Number of residues
- 305
- Molecular Weight
- 34655.63
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / non-membrane spanning protein tyrosine kinase activity / protein serine/threonine kinase activity / transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA bindingProcessescellular response to transforming growth factor beta stimulus / protein autophosphorylationComponentscytoplasm / cytosol / Golgi-associated vesicle / membrane / perinuclear region of cytoplasm
- General Function
- Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051962|Serine/threonine-protein kinase 16 (STK16) ATGGGCCACGCGCTGTGTGTCTGCTCTCGGGGAACTGTCATCATTGACAATAAGCGCTAC CTCTTCATCCAGAAACTGGGGGAGGGTGGGTTCAGCTATGTGGACCTAGTGGAAGGGTTA CATGATGGACACTTCTACGCCCTGAAGCGAATCCTGTGTCACGAGCAGCAGGACCGGGAG GAGGCCCAGCGAGAAGCCGACATGCATCGCCTCTTCAATCACCCCAACATCCTTCGCCTC GTGGCTTACTGTCTGAGGGAACGGGGTGCTAAGCATGAGGCCTGGCTGCTGCTACCATTC TTCAAGAGAGGTACGCTGTGGAATGAGATAGAAAGGCTGAAGGACAAAGGCAACTTCCTG ACCGAGGATCAAATCCTTTGGCTGCTGCTGGGGATCTGCAGAGGCCTTGAGGCCATTCAT GCCAAGGGTTATGCCCACAGAGACTTGAAGCCCACCAATATATTGCTTGGAGATGAGGGG CAGCCAGTTTTAATGGACTTGGGTTCCATGAATCAAGCATGCATCCATGTGGAGGGCTCC CGCCAGGCTCTGACCCTGCAGGACTGGGCAGCCCAGCGGTGCACCATCTCCTACCGAGCC CCAGAGCTCTTCTCTGTGCAGAGTCACTGTGTCATCGATGAGCGGACTGATGTCTGGTCC CTAGGCTGCGTGCTATATGCCATGATGTTTGGGGAAGGCCCTTATGACATGGTGTTCCAA AAGGGTGACAGTGTGGCCCTTGCTGTGCAGAACCAACTCAGCATCCCACAAAGCCCCAGG CATTCTTCAGCATTGCGGCAGCTCCTGAACTCGATGATGACCGTGGACCCGCATCAGCGT CCTCACATTCCTCTCCTCCTCAGTCAGCTGGAGGCGCTGCAGCCCCCAGCTCCTGGCCAA CATACTACCCAAATCTGA
- Chromosome Location
- 2
- Locus
- 2q35
- External Identifiers
Resource Link UniProtKB ID O75716 UniProtKB Entry Name STK16_HUMAN HGNC ID HGNC:11394 - General References
- Ligos JM, Gerwin N, Fernandez P, Gutierrez-Ramos JC, Bernad A: Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. Biochem Biophys Res Commun. 1998 Aug 19;249(2):380-4. [Article]
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