Neurotensin receptor type 2

Details

Name
Neurotensin receptor type 2
Synonyms
  • Levocabastine-sensitive neurotensin receptor
  • NT-R-2
Gene Name
NTSR2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037022|Neurotensin receptor type 2
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKA
RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY
ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL
ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV
PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA
VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
Number of residues
410
Molecular Weight
45384.635
Theoretical pI
9.64
GO Classification
Functions
G-protein coupled neurotensin receptor activity / G-protein coupled receptor activity
Processes
cell surface receptor signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway / regulation of membrane potential / sensory perception
Components
integral component of plasma membrane / plasma membrane
General Function
G-protein coupled receptor activity
Specific Function
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Pfam Domain Function
Transmembrane Regions
33-55 65-87 110-131 155-176 218-237 298-318 338-358
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016100|Neurotensin receptor type 2 (NTSR2)
ATGGAAACCAGCAGCCCGCGGCCCCCGCGGCCCAGCTCCAACCCGGGGCTGAGCCTGGAC
GCCCGGCTGGGCGTGGACACTCGCCTCTGGGCCAAGGTGCTGTTCACCGCGCTCTACGCA
CTCATCTGGGCGCTGGGCGCGGCGGGCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCG
CGGGCCGGGCGCGCGGGGCGCCTGCGCCACCACGTGCTCAGCCTGGCGCTCGCGGGCCTG
CTGCTGCTGCTGGTCGGCGTGCCGGTGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCC
TGGGTCTTCGGCGACCTGGGCTGCCGCGGCTACTACTTCGTGCACGAGCTGTGCGCCTAC
GCCACGGTGCTGAGCGTGGCAGGCCTGAGCGCCGAGCGCTGCCTAGCCGTGTGCCAGCCC
CTGCGTGCCCGCAGCCTGCTGACGCCACGCCGGACCCGGTGGCTGGTGGCGCTCTCGTGG
GCCGCCTCGCTCGGCCTCGCCCTGCCCATGGCCGTCATCATGGGGCAGAAGCACGAACTC
GAGACGGCGGACGGGGAGCCGGAGCCCGCCTCGCGAGTGTGCACGGTGCTGGTGAGCCGC
ACCGCGCTCCAAGTCTTTATCCAGGTGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCA
CTAACTGCTTTCCTGAATGGGGTCACAGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTG
CCGTCCACTTCTACCCCGGGCAGCTCCACCCCCAGCCGCCTGGAGCTGCTGAGTGAGGAG
GGTCTCCTCAGCTTCATCGTATGGAAGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTG
GTGAGACATAAAGACGTGCGCCGGATCCGCAGCCTCCAGCGCAGCGTCCAGGTTCTCAGA
GCCATCGTGGTCATGTATGTCATCTGCTGGCTGCCGTACCATGCCCGCAGGCTCATGTAC
TGCTACGTACCTGATGACGCGTGGACTGACCCACTGTACAATTTCTACCACTACTTCTAC
ATGGTGACCAACACACTTTTCTACGTCAGCTCAGCTGTGACTCCTCTTCTCTACAACGCC
GTGTCCTCCTCCTTCAGAAAACTCTTCCTGGAAGCCGTCAGCTCCCTGTGTGGAGAGCAC
CACCCCATGAAGCGGTTACCCCCGAAGCCCCAGAGTCCCACCCTAATGGATACAGCTTCA
GGCTTTGGGGATCCCCCAGAAACCCGGACCTGA
Chromosome Location
2
Locus
2p25.1
External Identifiers
ResourceLink
UniProtKB IDO95665
UniProtKB Entry NameNTR2_HUMAN
GenBank Protein ID3901028
GenBank Gene IDY10148
GenAtlas IDNTSR2
HGNC IDHGNC:8040
General References
  1. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P: Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur J Pharmacol. 1998 Nov 6;360(2-3):265-72. [Article]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Swift SL, Burns JE, Maitland NJ: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. Cancer Res. 2010 Jan 1;70(1):347-56. doi: 10.1158/0008-5472.CAN-09-1252. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01106Levocabastineapproved, investigationalyespartial antagonistDetails