Neurotensin receptor type 2
Details
- Name
- Neurotensin receptor type 2
- Synonyms
- Levocabastine-sensitive neurotensin receptor
- NT-R-2
- Gene Name
- NTSR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037022|Neurotensin receptor type 2 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKA RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
- Number of residues
- 410
- Molecular Weight
- 45384.635
- Theoretical pI
- 9.64
- GO Classification
- FunctionsG-protein coupled neurotensin receptor activity / G-protein coupled receptor activityProcessescell surface receptor signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway / regulation of membrane potential / sensory perceptionComponentsintegral component of plasma membrane / plasma membrane
- General Function
- G-protein coupled receptor activity
- Specific Function
- Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 33-55 65-87 110-131 155-176 218-237 298-318 338-358
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016100|Neurotensin receptor type 2 (NTSR2) ATGGAAACCAGCAGCCCGCGGCCCCCGCGGCCCAGCTCCAACCCGGGGCTGAGCCTGGAC GCCCGGCTGGGCGTGGACACTCGCCTCTGGGCCAAGGTGCTGTTCACCGCGCTCTACGCA CTCATCTGGGCGCTGGGCGCGGCGGGCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCG CGGGCCGGGCGCGCGGGGCGCCTGCGCCACCACGTGCTCAGCCTGGCGCTCGCGGGCCTG CTGCTGCTGCTGGTCGGCGTGCCGGTGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCC TGGGTCTTCGGCGACCTGGGCTGCCGCGGCTACTACTTCGTGCACGAGCTGTGCGCCTAC GCCACGGTGCTGAGCGTGGCAGGCCTGAGCGCCGAGCGCTGCCTAGCCGTGTGCCAGCCC CTGCGTGCCCGCAGCCTGCTGACGCCACGCCGGACCCGGTGGCTGGTGGCGCTCTCGTGG GCCGCCTCGCTCGGCCTCGCCCTGCCCATGGCCGTCATCATGGGGCAGAAGCACGAACTC GAGACGGCGGACGGGGAGCCGGAGCCCGCCTCGCGAGTGTGCACGGTGCTGGTGAGCCGC ACCGCGCTCCAAGTCTTTATCCAGGTGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCA CTAACTGCTTTCCTGAATGGGGTCACAGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTG CCGTCCACTTCTACCCCGGGCAGCTCCACCCCCAGCCGCCTGGAGCTGCTGAGTGAGGAG GGTCTCCTCAGCTTCATCGTATGGAAGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTG GTGAGACATAAAGACGTGCGCCGGATCCGCAGCCTCCAGCGCAGCGTCCAGGTTCTCAGA GCCATCGTGGTCATGTATGTCATCTGCTGGCTGCCGTACCATGCCCGCAGGCTCATGTAC TGCTACGTACCTGATGACGCGTGGACTGACCCACTGTACAATTTCTACCACTACTTCTAC ATGGTGACCAACACACTTTTCTACGTCAGCTCAGCTGTGACTCCTCTTCTCTACAACGCC GTGTCCTCCTCCTTCAGAAAACTCTTCCTGGAAGCCGTCAGCTCCCTGTGTGGAGAGCAC CACCCCATGAAGCGGTTACCCCCGAAGCCCCAGAGTCCCACCCTAATGGATACAGCTTCA GGCTTTGGGGATCCCCCAGAAACCCGGACCTGA
- Chromosome Location
- 2
- Locus
- 2p25.1
- External Identifiers
Resource Link UniProtKB ID O95665 UniProtKB Entry Name NTR2_HUMAN GenBank Protein ID 3901028 GenBank Gene ID Y10148 GenAtlas ID NTSR2 HGNC ID HGNC:8040 - General References
- Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P: Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur J Pharmacol. 1998 Nov 6;360(2-3):265-72. [Article]
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- Swift SL, Burns JE, Maitland NJ: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. Cancer Res. 2010 Jan 1;70(1):347-56. doi: 10.1158/0008-5472.CAN-09-1252. [Article]