Aminoglycoside 3'-phosphotransferase

Details

Name
Aminoglycoside 3'-phosphotransferase
Synonyms
  • 2.7.1.95
  • APH(3')-I
  • APH(3')I
  • Kanamycin kinase, type I
  • Neomycin-kanamycin phosphotransferase type I
  • nptI
Gene Name
aphA1
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0022078|Aminoglycoside 3'-phosphotransferase
MSHIQRETSCSRPRLNSNLDADLYGYKWARDNVGQSGATIYRLYGKPDAPELFLKHGKGS
VANDVTDEMVRLNWLTEFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENI
VDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWK
EMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFS
PSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF
Number of residues
271
Molecular Weight
30960.85
Theoretical pI
5.02
GO Classification
Functions
ATP binding / kanamycin kinase activity
Processes
response to antibiotic
General Function
Kanamycin kinase activity
Specific Function
Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006836|345 bp
ATGTGTTTTACTGTCAACGGCGAGATGCAGCTTACGCCAGATACGGCGGCGTTCCTGGCC
ATGCTTTTTGACTTTCCATTCGCCTTCACCAAAGACCTTCAGCCCGGTGGAATCAATCAC
CAGATGCGCGATTTCACCCCGGGTGAACGTTTTGAAACTGATATTAACCGACTTTGCCCG
CCTGCTGACACAGCTGTAATCCGGGCAGCGCAACGGAACATTCATCAGTGTAAAAATGGA
ATCAATAAAGCCCTGCGCAGCGCGCAGGGTCAGCCTGAATACGCGTTTAATGACCAGCAC
AGTCGTGATGGCAAGGTCAGAATAGCGCTGAGGTCTGCCTCGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP00551
UniProtKB Entry NameKKA1_ECOLX
GenBank Protein ID43026
GenBank Gene IDV00359
General References
  1. Oka A, Sugisaki H, Takanami M: Nucleotide sequence of the kanamycin resistance transposon Tn903. J Mol Biol. 1981 Apr 5;147(2):217-26. [Article]
  2. Vakulenko S, Kalman M, Horvath B, Simoncsits A: The nucleotide sequence of an aminoglycoside 3'-phosphotransferase gene from E. coli. Nucleic Acids Res. 1987 Oct 12;15(19):8111. [Article]
  3. Mochida S, Tsuchiya H, Mori K, Kaji A: Three short fragments of Rts1 DNA are responsible for the temperature-sensitive growth phenotype (Tsg) of host bacteria. J Bacteriol. 1991 Apr;173(8):2600-7. [Article]
  4. Menard R, Molinas C, Arthur M, Duval J, Courvalin P, Leclercq R: Overproduction of 3'-aminoglycoside phosphotransferase type I confers resistance to tobramycin in Escherichia coli. Antimicrob Agents Chemother. 1993 Jan;37(1):78-83. [Article]
  5. Grindley ND, Joyce CM: Genetic and DNA sequence analysis of the kanamycin resistance transposon Tn903. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7176-80. [Article]
  6. Grindley ND, Joyce CM: Analysis of the structure and function of the kanamycin-resistance transposon Tn903. Cold Spring Harb Symp Quant Biol. 1981;45 Pt 1:125-33. [Article]
  7. Heidekamp F, Baas PD, van Boom JH, Veeneman GH, Zipursky SL, Jansz HS: Construction and characterization of recombinant plasmid DNAs containing sequences of the origin of bacteriophage phi X174 DNA replication. Nucleic Acids Res. 1981 Jul 24;9(14):3335-54. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01172Kanamycinapproved, investigational, vet_approvedunknownsubstrateDetails