Tryptophan--tRNA ligase
Details
- Name
- Tryptophan--tRNA ligase
- Synonyms
- 6.1.1.2
- TrpRS
- Tryptophanyl-tRNA synthetase
- Gene Name
- trpS
- Organism
- Geobacillus stearothermophilus
- Amino acid sequence
>lcl|BSEQ0010937|Tryptophan--tRNA ligase MKTIFSGIQPSGVITIGNYIGALRQFVELQHEYNCYFCIVDQHAITVWQDPHELRQNIRR LAAKYLAVGIDPTQATLFIQSEVPAHAQAAWMLQCIVYIGELERMTQFKEKSAGKEAVSA GLLTYPPLMAADILLYNTDIVPVGEDQKQHIELTRDLAERFNKRYGELFTIPEARIPKVG ARIMSLVDPTKKMSKSDPNPKAYITLLDDAKTIEKKIKSAVTDSEGTIRYDKEAKPGISN LLNIYSTLSGQSIEELERQYEGKGYGVFKADLAQVVIETLRPIQERYHHWMESEELDRVL DEGAEKANRVASEMVRKMEQAMGLGRRR
- Number of residues
- 328
- Molecular Weight
- 37192.385
- Theoretical pI
- 6.64
- GO Classification
- FunctionsATP binding / tryptophan-tRNA ligase activityProcessestryptophanyl-tRNA aminoacylationComponentscytoplasm
- General Function
- Tryptophan-trna ligase activity
- Specific Function
- Not Available
- Pfam Domain Function
- tRNA-synt_1b (PF00579)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0002666|987 bp ATGAAAACCATTTTTTCCGGCATTCAGCCAAGCGGCGTCATCACCATTGGCAACTATATT GGGGCGCTGCGGCAGTTTGTCGAGCTGCAGCATGAATACAACTGCTATTTTTGCATCGTT GACCAACACGCCATTACCGTTTGGCAAGACCCACACGAACTGCGGCAAAACATCCGCCGC CTCGCCGCAAAGTATTTGGCCGTCGGCATCGACCCGACGCAAGCGACGTTGTTCATCCAG TCAGAAGTGCCGGCGCACGCTCAAGCCGCTTGGATGCTGCAGTGCATCGTTTATATCGGC GAACTTGAGCGGATGACGCAATTTAAAGAAAAATCGGCCGGCAAAGAGGCGGTCAGCGCC GGGCTGCTCACGTACCCGCCGCTGATGGCCGCTGACATTTTGCTTTATAACACCGACATC GTCCCGGTCGGCGAAGACCAAAAGCAGCATATCGAATTGACGCGGGATCTGGCCGAGCGC TTCAACAAACGGTATGGCGAGCTGTTTACGATCCCTGAGGCGCGCATTCCGAAAGTCGGC GCCCGCATCATGTCGCTTGTCGACCCGACGAAAAAAATGAGCAAATCCGACCCCAACCCG AAAGCGTACATCACACTGCTTGACGATGCGAAAACGATCGAGAAGAAGATCAAAAGCGCG GTCACCGACTCGGAAGGAACGATTCGCTACGACAAAGAAGCGAAGCCAGGCATTTCGAAC TTGCTCAATATTTATTCGACCCTATCCGGTCAATCGATCGAGGAGTTGGAGCGGCAATAC GAAGGAAAAGGATACGGCGTCTTCAAAGCAGACCTCGCTCAAGTCGTCATCGAAACGCTT CGACCGATTCAAGAGCGGTATCACCATTGGATGGAAAGCGAGGAGCTTGACCGCGTGTTG GATGAAGGGGCGGAAAAAGCAAATCGGGTTGCATCGGAAATGGTGCGAAAAATGGAGCAA GCCATGGGGCTCGGGCGGCGGCGGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P00953 UniProtKB Entry Name SYW_GEOSE GenBank Protein ID 143784 GenBank Gene ID M14742 - General References
- Barstow DA, Sharman AF, Atkinson T, Minton NP: Cloning and complete nucleotide sequence of the Bacillus stearothermophilus tryptophanyl tRNA synthetase gene. Gene. 1986;46(1):37-45. [Article]
- Winter GP, Hartley BS: The amino acid sequence of tryptophanyl tRNA synthetase from Bacillus stearothermophilus. FEBS Lett. 1977 Aug 15;80(2):340-2. [Article]
- Doublie S, Bricogne G, Gilmore C, Carter CW Jr: Tryptophanyl-tRNA synthetase crystal structure reveals an unexpected homology to tyrosyl-tRNA synthetase. Structure. 1995 Jan 15;3(1):17-31. [Article]
- Ilyin VA, Temple B, Hu M, Li G, Yin Y, Vachette P, Carter CW Jr: 2.9 A crystal structure of ligand-free tryptophanyl-tRNA synthetase: domain movements fragment the adenine nucleotide binding site. Protein Sci. 2000 Feb;9(2):218-31. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01831 Tryptophanyl-5'amp experimental unknown Details DB00150 Tryptophan approved, nutraceutical, withdrawn unknown inhibitor Details DB04537 Tryptophanamide experimental unknown Details DB00150 Tryptophan approved, nutraceutical, withdrawn unknown substrateinhibitor Details