Gastrin
Details
- Name
- Gastrin
- Synonyms
- GAS
- Gene Name
- GAST
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051969|Gastrin MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQL GPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN
- Number of residues
- 101
- Molecular Weight
- 11393.63
- Theoretical pI
- Not Available
- GO Classification
- Functionshormone activityProcessesG-protein coupled receptor signaling pathway / response to food / signal transductionComponentsextracellular region / extracellular space
- General Function
- Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
- Specific Function
- Hormone activity
- Pfam Domain Function
- Gastrin (PF00918)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0051970|Gastrin (GAST) ATGCAGCGACTATGTGTGTATGTGCTGATCTTTGCACTGGCTCTGGCCGCCTTCTCTGAA GCTTCTTGGAAGCCCCGCTCCCAGCAGCCAGATGCACCCTTAGGTACAGGGGCCAACAGG GACCTGGAGCTACCCTGGCTGGAGCAGCAGGGCCCAGCCTCTCATCATCGAAGGCAGCTG GGACCCCAGGGTCCCCCACACCTCGTGGCAGACCCGTCCAAGAAGCAGGGACCATGGCTG GAGGAAGAAGAAGAAGCCTATGGATGGATGGACTTCGGCCGCCGCAGTGCTGAGGATGAG AACTAA
- Chromosome Location
- 17
- Locus
- 17q21.2
- External Identifiers
Resource Link UniProtKB ID P01350 UniProtKB Entry Name GAST_HUMAN HGNC ID HGNC:4164 - General References
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- Ito R, Sato K, Helmer T, Jay G, Agarwal K: Structural analysis of the gene encoding human gastrin: the large intron contains an Alu sequence. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4662-6. [Article]
- Kato K, Hayashizaki Y, Takahashi Y, Himeno S, Matsubara K: Molecular cloning of the human gastrin gene. Nucleic Acids Res. 1983 Dec 10;11(23):8197-203. [Article]
- Boel E, Vuust J, Norris F, Norris K, Wind A, Rehfeld JF, Marcker KA: Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication. Proc Natl Acad Sci U S A. 1983 May;80(10):2866-9. [Article]
- Wiborg O, Berglund L, Boel E, Norris F, Norris K, Rehfeld JF, Marcker KA, Vuust J: Structure of a human gastrin gene. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1067-9. [Article]
- Kato K, Himeno S, Takahashi Y, Wakabayashi T, Tarui S, Matsubara K: Molecular cloning of human gastrin precursor cDNA. Gene. 1983 Dec;26(1):53-7. [Article]
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- Rehfeld JF, Johnsen AH: Identification of gastrin component I as gastrin-71. The largest possible bioactive progastrin product. Eur J Biochem. 1994 Aug 1;223(3):765-73. [Article]
- Bentley PH, Kenner GW, Sheppard RC: Structures of human gastrins I and II. Nature. 1966 Feb 5;209(5023):583-5. [Article]
- Higashimoto Y, Himeno S, Shinomura Y, Nagao K, Tamura T, Tarui S: Purification and structural determination of urinary NH2-terminal big gastrin fragments. Biochem Biophys Res Commun. 1989 May 15;160(3):1364-70. [Article]
- Gregory RA, Tracy HJ, Agarwal KL, Grossman MI: Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue. Gut. 1969 Aug;10(8):603-8. [Article]
- Varro A, Desmond H, Pauwels S, Gregory H, Young J, Dockray GJ: The human gastrin precursor. Characterization of phosphorylated forms and fragments. Biochem J. 1988 Dec 15;256(3):951-7. [Article]
- Rehfeld JF, Hansen CP, Johnsen AH: Post-poly(Glu) cleavage and degradation modified by O-sulfated tyrosine: a novel post-translational processing mechanism. EMBO J. 1995 Jan 16;14(2):389-96. [Article]
- Bundgaard JR, Vuust J, Rehfeld JF: Tyrosine O-sulfation promotes proteolytic processing of progastrin. EMBO J. 1995 Jul 3;14(13):3073-9. [Article]
- Palnaes Hansen C, Stadil F, Rehfeld JF: Metabolism and acid secretory effect of sulfated and nonsulfated gastrin-6 in humans. Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G903-9. doi: 10.1152/ajpgi.2000.279.5.G903. [Article]