C-reactive protein
Details
- Name
- C-reactive protein
- Synonyms
- PTX1
- Gene Name
- CRP
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001748|C-reactive protein MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
- Number of residues
- 224
- Molecular Weight
- 25038.385
- Theoretical pI
- 5.32
- GO Classification
- Functionscalcium ion binding / choline binding / complement component C1q binding / low-density lipoprotein particle binding / low-density lipoprotein particle receptor bindingProcessesacute-phase response / defense response to Gram-positive bacterium / inflammatory response / negative regulation of lipid storage / negative regulation of macrophage derived foam cell differentiation / negative regulation of vasodilation / opsonization / positive regulation of gene expression / positive regulation of superoxide anion generation / regulation of interleukin-8 secretionComponentsextracellular exosome / extracellular region / extracellular space
- General Function
- Low-density lipoprotein particle receptor binding
- Specific Function
- Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
- Pfam Domain Function
- Pentaxin (PF00354)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016238|C-reactive protein (CRP) ATGGAGAAGCTGTTGTGTTTCTTGGTCTTGACCAGCCTCTCTCATGCTTTTGGCCAGACA GACATGTCGAGGAAGGCTTTTGTGTTTCCCAAAGAGTCGGATACTTCCTATGTATCCCTC AAAGCACCGTTAACGAAGCCTCTCAAAGCCTTCACTGTGTGCCTCCACTTCTACACGGAA CTGTCCTCGACCCGTGGGTACAGTATTTTCTCGTATGCCACCAAGAGACAAGACAATGAG ATTCTCATATTTTGGTCTAAGGATATAGGATACAGTTTTACAGTGGGTGGGTCTGAAATA TTATTCGAGGTTCCTGAAGTCACAGTAGCTCCAGTACACATTTGTACAAGCTGGGAGTCC GCCTCAGGGATCGTGGAGTTCTGGGTAGATGGGAAGCCCAGGGTGAGGAAGAGTCTGAAG AAGGGATACACTGTGGGGGCAGAAGCAAGCATCATCTTGGGGCAGGAGCAGGATTCCTTC GGTGGGAACTTTGAAGGAAGCCAGTCCCTGGTGGGAGACATTGGAAATGTGAACATGTGG GACTTTGTGCTGTCACCAGATGAGATTAACACCATCTATCTTGGCGGGCCCTTCAGTCCT AATGTCCTGAACTGGCGGGCACTGAAGTATGAAGTGCAAGGCGAAGTGTTCACCAAACCC CAGCTGTGGCCCTGA
- Chromosome Location
- 1
- Locus
- 1q21-q23
- External Identifiers
Resource Link UniProtKB ID P02741 UniProtKB Entry Name CRP_HUMAN GenBank Protein ID 181066 GenBank Gene ID M11880 GenAtlas ID CRP HGNC ID HGNC:2367 - General References
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