Alpha-1-acid glycoprotein 1

Details

Name
Alpha-1-acid glycoprotein 1
Synonyms
  • AGP 1
  • AGP1
  • OMD 1
  • Orosomucoid-1
Gene Name
ORM1
Organism
Human
Amino acid sequence
>lcl|BSEQ0001842|Alpha-1-acid glycoprotein 1
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAFRNEEYNKSVQ
EIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLL
ILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKK
DKCEPLEKQHEKERKQEEGES
Number of residues
201
Molecular Weight
23511.38
Theoretical pI
4.66
GO Classification
Processes
transport / inflammatory response / acute-phase response / negative regulation of tumor necrosis factor production / regulation of immune system process / negative regulation of interleukin-6 production
Components
extracellular region / extracellular space / extracellular exosome / blood microparticle
General Function
Not Available
Specific Function
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010649|Alpha-1-acid glycoprotein 1 (ORM1)
ATGGCGCTGTCCTGGGTTCTTACAGTCCTGAGCCTCCTACCTCTGCTGGAAGCCCAGATC
CCATTGTGTGCCAACCTAGTACCGGTGCCCATCACCAACGCCACCCTGGACCGGATCACT
GGCAAGTGGTTTTATATCGCATCGGCCTTTCGAAACGAGGAGTACAATAAGTCGGTTCAG
GAGATCCAAGCAACCTTCTTTTACTTCACCCCCAACAAGACAGAGGACACGATCTTTCTC
AGAGAGTACCAGACCCGACAGGACCAGTGCATCTATAACACCACCTACCTGAATGTCCAG
CGGGAAAATGGGACCATCTCCAGATACGTGGGAGGCCAAGAGCATTTCGCTCACTTGCTG
ATCCTCAGGGACACCAAGACCTACATGCTTGCTTTTGACGTGAACGATGAGAAGAACTGG
GGGCTGTCTGTCTATGCTGACAAGCCAGAGACGACCAAGGAGCAACTGGGAGAGTTCTAC
GAAGCTCTCGACTGCTTGCGCATTCCCAAGTCAGATGTCGTGTACACCGATTGGAAAAAG
GATAAGTGTGAGCCACTGGAGAAGCAGCACGAGAAGGAGAGGAAACAGGAGGAGGGGGAA
TCCTAG
Chromosome Location
9
Locus
9q31-q32
External Identifiers
ResourceLink
UniProtKB IDP02763
UniProtKB Entry NameA1AG1_HUMAN
GenBank Protein ID757907
GenBank Gene IDX02544
GenAtlas IDORM1
HGNC IDHGNC:8498
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00280Disopyramideapprovednoother/unknownDetails
DB00706Tamsulosinapproved, investigationalnoDetails
DB00908Quinidineapproved, investigationalunknownDetails
DB00946Phenprocoumonapproved, investigationalnoDetails
DB01359Penbutololapproved, investigationalunknownother/unknownDetails
DB01429AprindineapprovedunknownDetails
DB01418Acenocoumarolapproved, investigationalnoDetails
DB00682WarfarinapprovednoDetails
DB00802Alfentanilapproved, illicitunknownDetails
DB00540NortriptylineapprovednoDetails
DB00321AmitriptylineapprovednoDetails
DB01232Saquinavirapproved, investigationalunknownDetails
DB00334Olanzapineapproved, investigationalunknownDetails
DB01142Doxepinapproved, investigationalunknownother/unknownDetails
DB00543AmoxapineapprovednoDetails
DB00656Trazodoneapproved, investigationalnoDetails
DB00457PrazosinapprovednoDetails
DB00590DoxazosinapprovednoDetails
DB00571Propranololapproved, investigationalnoDetails
DB00458ImipramineapprovednoDetails
DB01151Desipramineapproved, investigationalnoDetails
DB04821NomifensinewithdrawnnoDetails
DB01156BupropionapprovednoantagonistDetails
DB00934Maprotilineapproved, investigationalnoDetails
DB01426Ajmalineapproved, investigationalunknownDetails
DB00454PethidineapprovedunknownDetails
DB00731Nateglinideapproved, investigationalunknownDetails
DB08867UlipristalapprovednosubstrateDetails
DB05294VandetanibapprovedunknownbinderDetails
DB05521Telaprevirapproved, withdrawnnosubstrateDetails
DB05812AbirateroneapprovedunknownsubstrateDetails
DB08881VemurafenibapprovedunknownsubstrateDetails
DB08828Vismodegibapproved, investigationalunknownsubstrateDetails
DB08893MirabegronapprovednosubstrateDetails
DB08820IvacaftorapprovednocarrierDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB08907CanagliflozinapprovedunknownsubstrateDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateDetails
DB00619ImatinibapprovedunknownsubstrateDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails
DB08931RiociguatapprovedunknownsubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB01685Topiroxostatapproved, investigationalunknownbinderDetails
DB00276Amsacrineapproved, investigationalunknownDetails
DB00396Progesteroneapproved, vet_approvedunknownDetails
DB00975DipyridamoleapprovedunknownDetails
DB00281Lidocaineapproved, vet_approvedunknownDetails
DB09236Lacidipineapproved, investigationalunknownbinderDetails
DB09204ArotinololinvestigationalnosubstrateDetails
DB09229Aranidipineapproved, investigationalnobinderDetails
DB11148Butambenapproved, withdrawnnosubstrateDetails
DB11637Delamanidapproved, investigationalunknownsubstrateDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownbinderDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownbinderDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownbinderDetails
DB09262Imidafenacinapproved, investigationalnosubstrateDetails
DB11828Neratinibapproved, investigationalnosubstrateDetails
DB00512VancomycinapprovednosubstrateDetails
DB12001Abemaciclibapproved, investigationalunknownbinderDetails
DB09053IbrutinibapprovednosubstrateDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails