Serum albumin

Details

Name
Serum albumin
Synonyms
  • Serum albumin precursor
Gene Name
ALB
Organism
Human
Amino acid sequence
>lcl|BSEQ0001058|Serum albumin
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Number of residues
609
Molecular Weight
69365.94
Theoretical pI
6.21
GO Classification
Functions
drug binding / pyridoxal phosphate binding / fatty acid binding / copper ion binding / antioxidant activity / chaperone binding / toxic substance binding / DNA binding
Processes
negative regulation of programmed cell death / platelet degranulation / retina homeostasis / platelet activation / transport / sodium-independent organic anion transport / lipoprotein metabolic process / bile acid metabolic process / small molecule metabolic process / bile acid and bile salt transport / blood coagulation / transmembrane transport / cellular response to starvation / receptor-mediated endocytosis / hemolysis by symbiont of host erythrocytes / negative regulation of apoptotic process / maintenance of mitochondrion location
Components
platelet alpha granule lumen / extracellular space / blood microparticle / protein complex / Golgi apparatus / extracellular exosome / myelin sheath / extracellular region / nucleus / endoplasmic reticulum
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010372|Serum albumin (ALB)
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GAGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCCTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTATTAGTTCGTTACACCAAGAAAGTACCC
CAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCAGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA
Chromosome Location
4
Locus
4q11-q13
External Identifiers
ResourceLink
UniProtKB IDP02768
UniProtKB Entry NameALBU_HUMAN
GenBank Protein ID28590
GenBank Gene IDV00494
GenAtlas IDALB
HGNC IDHGNC:399
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00070Hyaluronidaseapproved, investigationalunknowninhibitorDetails
DB00137Luteinapproved, nutraceuticalunknownDetails
DB00364SucralfateapprovedunknownDetails
DB00459AcitretinapprovedunknownDetails
DB00576Sulfamethizoleapproved, investigational, vet_approvedunknownDetails
DB00743Gadobenic acidapprovedunknownbinderDetails
DB00815Sodium lauryl sulfateapprovedunknownbinderDetails
DB00936Salicylic acidapproved, vet_approvednoother/unknownDetails
DB00946Phenprocoumonapproved, investigationalnoDetails
DB00995AuranofinapprovedunknownDetails
DB01120GliclazideapprovedunknownDetails
DB01328Cefonicidapproved, investigationalnoother/unknownDetails
DB01329Cefoperazoneapproved, investigationalnoother/unknownDetails
DB01396Digitoxinapproved, investigationalnoDetails
DB03017Lauric Acidapproved, experimentalunknownDetails
DB03193Stearic acidapproved, experimentalunknownDetails
DB03600Capric acidexperimentalnoDetails
DB03796Palmitic Acidapproved, experimentalunknownDetails
DB04224Oleic Acidapproved, vet_approvedunknownDetails
DB04557Arachidonic AcidexperimentalnoDetails
DB04711IodipamideapprovedunknownbinderDetails
DB06412Oxymetholoneapproved, illicitunknownDetails
DB01197Captoprilapprovednoother/unknownDetails
DB01050IbuprofenapprovedunknownDetails
DB00563MethotrexateapprovednoDetails
DB00451LevothyroxineapprovednoDetails
DB00279Liothyronineapproved, vet_approvedunknownDetails
DB00605SulindacapprovedunknownDetails
DB00749Etodolacapproved, investigational, vet_approvedunknownDetails
DB00861DiflunisalapprovedunknownDetails
DB01009Ketoprofenapproved, vet_approvedunknownDetails
DB00586Diclofenacapproved, vet_approvedunknownDetails
DB00783Estradiolapproved, investigational, vet_approvednoDetails
DB00655EstroneapprovednoDetails
DB00624Testosteroneapproved, investigationalnoother/unknownDetails
DB01307Insulin Detemirapprovednoother/unknownDetails
DB01418AcenocoumarolapprovednoDetails
DB00802Alfentanilapproved, illicitunknownDetails
DB00818Propofolapproved, investigational, vet_approvednoDetails
DB00228Enfluraneapproved, investigational, vet_approvedunknownDetails
DB00753Isofluraneapproved, vet_approvedunknownDetails
DB01189DesfluraneapprovedunknownDetails
DB01159Halothaneapproved, vet_approvedunknownDetails
DB01236Sevofluraneapproved, vet_approvedunknownDetails
DB00252Phenytoinapproved, vet_approvedunknownDetails
DB00477Chlorpromazineapproved, vet_approvedunknownDetails
DB00540NortriptylineapprovednoDetails
DB00321AmitriptylineapprovednoDetails
DB00903Etacrynic acidapprovedunknownDetails
DB00695Furosemideapproved, vet_approvedunknownDetails
DB00829Diazepamapproved, illicit, vet_approvednoDetails
DB00682WarfarinapprovednoDetails
DB00554Piroxicamapproved, investigationalunknownDetails
DB00573FenoprofenapprovedunknownDetails
DB00328Indomethacinapproved, investigationalunknownDetails
DB03585Oxyphenbutazoneapproved, withdrawnunknownDetails
DB00544FluorouracilapprovednoDetails
DB00945Acetylsalicylic acidapproved, vet_approvednoother/unknownDetails
DB01232Saquinavirapproved, investigationalunknownDetails
DB01032ProbenecidapprovednoDetails
DB01044Gatifloxacinapproved, investigationalunknownother/unknownDetails
DB01068Clonazepamapproved, illicitnoDetails
DB01147Cloxacillinapproved, vet_approvedunknownDetails
DB01327Cefazolinapprovedunknownother/unknownDetails
DB00931Methacyclineapproved, investigationalnoDetails
DB01015SulfamethoxazoleapprovednoDetails
DB00415Ampicillinapproved, vet_approvednoother/unknownDetails
DB00567Cephalexinapproved, vet_approvednoother/unknownDetails
DB00759Tetracyclineapproved, vet_approvednoDetails
DB01212Ceftriaxoneapprovednoother/unknownDetails
DB01330CefotetanapprovednoDetails
DB00274Cefmetazoleapproved, investigationalnoDetails
DB00495ZidovudineapprovednoDetails
DB01397Magnesium salicylateapprovednoDetails
DB00788Naproxenapproved, vet_approvednoDetails
DB00334Olanzapineapproved, investigationalunknownDetails
DB01056Tocainideapprovednoother/unknownDetails
DB01320Fosphenytoinapprovednoother/unknownDetails
DB00712Flurbiprofenapproved, investigationalnoother/unknownDetails
DB07402AzapropazonewithdrawnunknownDetails
DB075173-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONICexperimentalunknownDetails
DB079923-SULFOOXY-1H-INDOLEexperimentalunknownDetails
DB08231Myristic acidexperimentalunknownDetails
DB08735R,S-Warfarin alcoholexperimentalunknownDetails
DB08736S,R-Warfarin alcoholexperimentalunknownDetails
DB00430CefpiramideapprovedunknownDetails
DB01583LiotrixapprovedunknownDetails
DB01294Bismuth Subsalicylateapproved, vet_approvedunknownbinderDetails
DB00456Cefalotinapproved, vet_approvedunknownbinderDetails
DB01581Sulfamerazineapproved, vet_approvedunknownDetails
DB01582Sulfamethazineapproved, investigational, vet_approvedunknownDetails
DB01587KetazolamapprovedunknownDetails
DB01614Acepromazineapproved, vet_approvedunknownDetails
DB01621Pipotiazineapproved, investigationalunknownDetails
DB04574Estrone sulfateapprovedunknownDetails
DB06710MethyltestosteroneapprovedunknownDetails
DB01622ThioproperazineapprovedunknownDetails
DB01623ThiothixeneapprovedunknownDetails
DB06705Gadofosveset trisodiumapprovedunknownsubstrateDetails
DB00454PethidineapprovedunknownDetails
DB01016GlyburideapprovedunknownDetails
DB00177Valsartanapproved, investigationalunknownDetails
DB00912Repaglinideapproved, investigationalunknownDetails
DB00731Nateglinideapproved, investigationalunknownDetails
DB08867UlipristalapprovednosubstrateDetails
DB05294VandetanibapprovedunknownbinderDetails
DB05521Telaprevirapproved, withdrawnnosubstrateDetails
DB05812AbirateroneapprovedunknownsubstrateDetails
DB08881VemurafenibapprovedunknownsubstrateDetails
DB08828VismodegibapprovedunknownsubstrateDetails
DB08893MirabegronapprovednosubstrateDetails
DB00635Prednisoneapproved, vet_approvedunknownsubstrateDetails
DB08899EnzalutamideapprovedunknownsubstrateDetails
DB08820IvacaftorapprovednocarrierDetails
DB00776OxcarbazepineapprovedunknownsubstrateDetails
DB06201RufinamideapprovedunknownsubstrateDetails
DB06716Fospropofolapproved, illicit, investigationalunknownsubstrateDetails
DB04855DronedaroneapprovedunknownsubstrateDetails
DB06209PrasugrelapprovedunknownsubstrateDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB08907CanagliflozinapprovedunknownsubstrateDetails
DB01183Naloxoneapproved, vet_approvedunknownsubstrateDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateDetails
DB01242Clomipramineapproved, vet_approvedunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateDetails
DB00619ImatinibapprovedunknownsubstrateDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB00678LosartanapprovedunknownsubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB00412Rosiglitazoneapproved, investigationalunknownsubstrateDetails
DB01098RosuvastatinapprovedunknownsubstrateDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails
DB00717NorethisteroneapprovedunknownsubstrateDetails
DB08931RiociguatapprovedunknownsubstrateDetails
DB08895Tofacitinibapproved, investigationalunknownDetails
DB08932MacitentanapprovednobinderDetails
DB06290SimeprevirapprovednobinderDetails
DB00199Erythromycinapproved, vet_approvednobinderDetails
DB00493CefotaximeapprovedunknownDetails
DB01045RifampicinapprovedunknownDetails
DB06205Hyaluronidase (Human Recombinant)approvedunknowninhibitorDetails
DB09280LumacaftorapprovednocarrierDetails
DB09130CopperapprovednobinderDetails
DB11093Calcium CitrateapprovednosubstrateDetails
DB11348Calcium PhosphateapprovednosubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB11943Delafloxacinapproved, investigationalnosubstrateDetails
DB01685Topiroxostatapproved, investigationalunknownbinderDetails
DB09093Chlortetracyclineapproved, investigational, vet_approvednoDetails
DB06796Mangafodipirapproved, withdrawnunknownbinderDetails
DB09262Imidafenacinapproved, investigationalnosubstrateDetails
DB00276AmsacrineapprovedunknownDetails
DB11359GuaiacolapprovedunknownDetails
DB03255Phenolapproved, experimentalunknownDetails
DB06728AnilineexperimentalunknownDetails
DB00545PyridostigmineapprovedunknownDetails
DB06713NorelgestrominapprovedunknownDetails
DB01370AluminiumapprovedunknownDetails
DB13014HypericininvestigationalunknownDetails
DB01057EchothiophateapprovedunknownDetails
DB00677Isoflurophateapproved, investigational, withdrawnunknownDetails
DB00943Zalcitabineapproved, investigationalunknownDetails
DB01072Atazanavirapproved, investigationalunknownDetails
DB00649Stavudineapproved, investigationalunknownDetails
DB00900DidanosineapprovedunknownDetails
DB00625Efavirenzapproved, investigationalunknownDetails
DB00879Emtricitabineapproved, investigationalunknownDetails
DB00220NelfinavirapprovedunknownDetails
DB00238NevirapineapprovedunknownDetails
DB00503Ritonavirapproved, investigationalunknownDetails
DB00709Lamivudineapproved, investigationalunknownDetails
DB04216Quercetinexperimental, investigationalunknownDetails
DB00997Doxorubicinapproved, investigationalunknownDetails
DB04816Danthroninvestigational, withdrawnunknownDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownDetails
DB00515CisplatinapprovedunknownDetails
DB00158Folic Acidapproved, nutraceutical, vet_approvedunknownDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknownDetails
DB04690CamptothecinexperimentalunknownDetails
DB02709Resveratrolapproved, experimental, investigationalunknownDetails
DB00744Zileutonapproved, investigational, withdrawnunknownDetails
DB04539GlyphosateexperimentalunknownDetails
DB11590ThimerosalapprovedunknownDetails
DB05134TanespimycininvestigationalunknownDetails
DB01124TolbutamideapprovedunknownDetails
DB01276Exenatideapproved, investigationalunknownDetails
DB00414Acetohexamideinvestigational, withdrawnunknownDetails
DB00458ImipramineapprovedunknownDetails
DB00159Icosapentapproved, nutraceuticalunknownDetails
DB00951IsoniazidapprovedunknownDetails
DB11638Artenimolapproved, investigationalunknownDetails
DB01104SertralineapprovedunknownDetails
DB00266DicoumarolapprovedunknownDetails
DB04828ZomepiracwithdrawnunknownDetails
DB00500TolmetinapprovedunknownDetails
DB11217ArbutinapprovedunknownDetails
DB09526HydroquinoneapprovedunknownDetails
DB00784Mefenamic acidapprovedunknownDetails
DB00313Valproic Acidapproved, investigationalunknownDetails
DB01169Arsenic trioxideapproved, investigationalnosubstrateDetails
DB11828Neratinibapproved, investigationalnosubstrateDetails
DB00607NafcillinapprovedunknownDetails
DB12483CopanlisibapprovedunknownsubstrateDetails
DB00512VancomycinapprovednosubstrateDetails
DB12001AbemaciclibapprovedunknownbinderDetails
DB08864Rilpivirineapprovednoother/unknownDetails
DB13928Semaglutideapproved, investigationalnosubstrateDetails
DB09087Potassium alumapprovedunknownbinderDetails