Vitamin D-binding protein

Details

Name
Vitamin D-binding protein
Synonyms
  • DBP
  • DBP-maf
  • Gc
  • Gc protein-derived macrophage activating factor
  • Gc-globulin
  • Gc-MAF
  • GcMAF
  • Group-specific component
  • Vitamin D-binding protein-macrophage activating factor
Gene Name
GC
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002269|Vitamin D-binding protein
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
KLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
Number of residues
474
Molecular Weight
52963.025
Theoretical pI
5.21
GO Classification
Functions
actin binding / calcidiol binding / vitamin D binding / vitamin transporter activity
Processes
female pregnancy / lactation / response to estradiol / response to nutrient levels / small molecule metabolic process / steroid metabolic process / vitamin D metabolic process / vitamin transport
Components
axon / blood microparticle / cytosol / extracellular exosome / extracellular region / extracellular space / lysosomal lumen / perinuclear region of cytoplasm
General Function
Vitamin transporter activity
Specific Function
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010798|Vitamin D-binding protein (GC)
ATGAAGAGGGTCCTGGTACTACTGCTTGCTGTGGCATTTGGACATGCTTTAGAGAGAGGC
CGGGATTATGAAAAGAATAAAGTCTGCAAGGAATTCTCCCATCTGGGAAAGGAGGACTTC
ACATCTCTGTCACTAGTCCTGTACAGTAGAAAATTTCCCAGTGGCACGTTTGAACAGGTC
AGCCAACTTGTGAAGGAAGTTGTCTCCTTGACCGAAGCCTGCTGTGCGGAAGGGGCTGAC
CCTGACTGCTATGACACCAGGACCTCAGCACTGTCTGCCAAGTCCTGTGAAAGTAATTCT
CCATTCCCCGTTCACCCAGGCACTGCTGAGTGCTGCACCAAAGAGGGCCTGGAACGAAAG
CTCTGCATGGCTGCTCTGAAACACCAGCCACAGGAATTCCCTACCTACGTGGAACCCACA
AATGATGAAATCTGTGAGGCGTTCAGGAAAGATCCAAAGGAATATGCTAATCAATTTATG
TGGGAATATTCCACTAATTACGGACAAGCTCCTCTGTCACTTTTAGTCAGTTACACCAAG
AGTTATCTTTCTATGGTAGGGTCCTGCTGTACCTCTGCAAGCCCAACTGTATGCTTTTTG
AAAGAGAGACTCCAGCTTAAACATTTATCACTTCTCACCACTCTGTCAAATAGAGTCTGC
TCACAATATGCTGCTTATGGGGAGAAGAAATCAAGGCTCAGCAATCTCATAAAGTTAGCC
CAAAAAGTGCCTACTGCTGATCTGGAGGATGTTTTGCCACTAGCTGAAGATATTACTAAC
ATCCTCTCCAAATGCTGTGAGTCTGCCTCTGAAGATTGCATGGCCAAAGAGCTGCCTGAA
CACACAGTAAAACTCTGTGACAATTTATCCACAAAGAATTCTAAGTTTGAAGACTGTTGT
CAAGAAAAAACAGCCATGGACGTTTTTGTGTGCACTTACTTCATGCCAGCTGCCCAACTC
CCCGAGCTTCCAGATGTAGAGTTGCCCACAAACAAAGATGTGTGTGATCCAGGAAACACC
AAAGTCATGGATAAGTATACATTTGAACTAAGCAGAAGGACTCATCTTCCGGAAGTATTC
CTCAGTAAGGTACTTGAGCCAACCCTAAAAAGCCTTGGTGAATGCTGTGATGTTGAAGAC
TCAACTACCTGTTTTAATGCTAAGGGCCCTCTACTAAAGAAGGAACTATCTTCTTTCATT
GACAAGGGACAAGAACTATGTGCAGATTATTCAGAAAATACATTTACTGAGTACAAGAAA
AAACTGGCAGAGCGACTAAAAGCAAAATTGCCTGATGCCACACCCACGGAACTGGCAAAG
CTGGTTAACAAGCACTCAGACTTTGCCTCCAACTGCTGTTCCATAAACTCACCTCCTCTT
TACTGTGATTCAGAGATTGATGCTGAATTGAAGAATATCCTGTAG
Chromosome Location
4
Locus
4q12-q13
External Identifiers
ResourceLink
UniProtKB IDP02774
UniProtKB Entry NameVTDB_HUMAN
GenBank Protein ID639896
GenBank Gene IDL10641
GenAtlas IDGC
HGNC IDHGNC:4187
General References
  1. Cooke NE, David EV: Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family. J Clin Invest. 1985 Dec;76(6):2420-4. [Article]
  2. Yang F, Brune JL, Naylor SL, Cupples RL, Naberhaus KH, Bowman BH: Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci U S A. 1985 Dec;82(23):7994-8. [Article]
  3. Braun A, Kofler A, Morawietz S, Cleve H: Sequence and organization of the human vitamin D-binding protein gene. Biochim Biophys Acta. 1993 Dec 14;1216(3):385-94. [Article]
  4. Witke WF, Gibbs PE, Zielinski R, Yang F, Bowman BH, Dugaiczyk A: Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family. Genomics. 1993 Jun;16(3):751-4. [Article]
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  8. Yang F, Naberhaus KH, Adrian GS, Gardella JM, Brissenden JE, Bowman BH: The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals. Gene. 1987;54(2-3):285-90. [Article]
  9. Schoentgen F, Metz-Boutigue MH, Jolles J, Constans J, Jolles P: Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein. Biochim Biophys Acta. 1986 Jun 5;871(2):189-98. [Article]
  10. Svasti J, Kurosky A, Bennett A, Bowman BH: Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component). Biochemistry. 1979 Apr 17;18(8):1611-7. [Article]
  11. Ravnsborg T, Olsen DT, Thysen AH, Christiansen M, Houen G, Hojrup P: The glycosylation and characterization of the candidate Gc macrophage activating factor. Biochim Biophys Acta. 2010 Apr;1804(4):909-17. doi: 10.1016/j.bbapap.2009.12.022. Epub 2010 Jan 13. [Article]
  12. Kofler A, Braun A, Jenkins T, Serjeantson SW, Cleve H: Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany. Vox Sang. 1995;68(1):50-4. [Article]
  13. Nagasawa H, Uto Y, Sasaki H, Okamura N, Murakami A, Kubo S, Kirk KL, Hori H: Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity. Anticancer Res. 2005 Nov-Dec;25(6A):3689-95. [Article]
  14. Christiansen M, Jorgensen CS, Laursen I, Hirschberg D, Hojrup P, Houen G: Protein chemical characterization of Gc globulin (vitamin D-binding protein) isoforms; Gc-1f, Gc-1s and Gc-2. Biochim Biophys Acta. 2007 Apr;1774(4):481-92. Epub 2007 Feb 12. [Article]
  15. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  16. Braun A, Bichlmaier R, Cleve H: Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types. Hum Genet. 1992 Jun;89(4):401-6. [Article]
  17. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C: A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol. 2002 Feb;9(2):131-6. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04224Oleic Acidapproved, investigational, vet_approvedunknownDetails
DB00169Cholecalciferolapproved, nutraceuticalnoDetails
DB01436Alfacalcidolapproved, nutraceuticalunknownsubstrateDetails
DB11094Vitamin Dapproved, nutraceutical, vet_approvedunknownDetails
DB00136Calcitriolapproved, nutraceuticalnobinderDetails
DB00153Ergocalciferolapproved, nutraceuticalnobinderDetails