Superoxide dismutase [Mn], mitochondrial

Details

Name
Superoxide dismutase [Mn], mitochondrial
Synonyms
  • 1.15.1.1
Gene Name
SOD2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009374|Superoxide dismutase [Mn], mitochondrial
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
Number of residues
222
Molecular Weight
24721.955
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / manganese ion binding / superoxide dismutase activity
Processes
age-dependent response to reactive oxygen species / negative regulation of cell proliferation / negative regulation of neuron apoptotic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / oxygen homeostasis / protein homotetramerization / regulation of blood pressure / regulation of transcription from RNA polymerase II promoter / release of cytochrome c from mitochondria / removal of superoxide radicals / response to reactive oxygen species / response to superoxide / superoxide metabolic process / vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
Components
extracellular exosome / mitochondrial matrix / mitochondrion
General Function
Superoxide dismutase activity
Specific Function
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion matrix
Gene sequence
>lcl|BSEQ0013118|Superoxide dismutase [Mn], mitochondrial (SOD2)
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGTTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCACCGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA
Chromosome Location
6
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP04179
UniProtKB Entry NameSODM_HUMAN
HGNC IDHGNC:11180
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03297Benzylsulfonic acidexperimentalunknownDetails
DB044363-Fluoro-L-tyrosineexperimentalunknownDetails
DB06796Mangafodipirapproved, investigational, withdrawnunknownactivatorDetails
DB09221PolaprezincexperimentalunknowninducerDetails
DB11590ThimerosalapprovedunknowninducerDetails
DB09096Benzoyl peroxideapprovedunknowninhibitorDetails