Cytochrome P450 1A2

Details

Name
Cytochrome P450 1A2
Synonyms
  • 1.14.14.1
  • Cholesterol 25-hydroxylase
  • CYPIA2
  • Cytochrome P(3)450
  • Cytochrome P450 4
  • Cytochrome P450-P3
Gene Name
CYP1A2
Organism
Human
Amino acid sequence
>lcl|BSEQ0004778|Cytochrome P450 1A2
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARRFSIN
Number of residues
515
Molecular Weight
58293.76
Theoretical pI
9.43
GO Classification
Functions
oxidoreductase activity / iron ion binding / heme binding / monooxygenase activity / aromatase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / caffeine oxidase activity / enzyme binding / demethylase activity / electron carrier activity
Processes
porphyrin-containing compound metabolic process / dibenzo-p-dioxin metabolic process / lung development / methylation / drug catabolic process / post-embryonic development / epoxygenase P450 pathway / heterocycle metabolic process / exogenous drug catabolic process / hydrogen peroxide biosynthetic process / oxidation-reduction process / steroid catabolic process / cellular respiration / monoterpenoid metabolic process / regulation of gene expression / omega-hydroxylase P450 pathway / response to lipopolysaccharide / monocarboxylic acid metabolic process / oxidative deethylation / response to immobilization stress / oxidative demethylation / xenobiotic metabolic process / toxin biosynthetic process / arachidonic acid metabolic process / alkaloid metabolic process / small molecule metabolic process / drug metabolic process / cellular response to cadmium ion / response to estradiol
Components
intracellular membrane-bounded organelle / endoplasmic reticulum membrane
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011742|Cytochrome P450 1A2 (CYP1A2)
ATGGCATTGTCCCAGTCTGTTCCCTTCTCGGCCACAGAGCTTCTCCTGGCCTCTGCCATC
TTCTGCCTGGTATTCTGGGTGCTCAAGGGTTTGAGGCCTCGGGTCCCCAAAGGCCTGAAA
AGTCCACCAGAGCCATGGGGCTGGCCCTTGCTCGGGCATGTGCTGACCCTGGGGAAGAAC
CCGCACCTGGCACTGTCAAGGATGAGCCAGCGCTACGGGGACGTCCTGCAGATCCGCATT
GGCTCCACGCCCGTGCTGGTGCTGAGCCGCCTGGACACCATCCGGCAGGCCCTGGTGCGG
CAGGGCGACGATTTCAAGGGCCGGCCTGACCTCTACACCTCCACCCTCATCACTGATGGC
CAGAGCTTGACCTTCAGCACAGACTCTGGACCGGTGTGGGCTGCCCGCCGGCGCCTGGCC
CAGAATGCCCTCAACACCTTCTCCATCGCCTCTGACCCAGCTTCCTCATCCTCCTGCTAC
CTGGAGGAGCATGTGAGCAAGGAGGCTAAGGCCCTGATCAGCAGGTTGCAGGAGCTGATG
GCAGGGCCTGGGCACTTCGACCCTTACAATCAGGTGGTGGTGTCAGTGGCCAACGTCATT
GGTGCCATGTGCTTCGGACAGCACTTCCCTGAGAGTAGCGATGAGATGCTCAGCCTCGTG
AAGAACACTCATGAGTTCGTGGAGACTGCCTCCTCCGGGAACCCCCTGGACTTCTTCCCC
ATCCTTCGCTACCTGCCTAACCCTGCCCTGCAGAGGTTCAAGGCCTTCAACCAGAGGTTC
CTGTGGTTCCTGCAGAAAACAGTCCAGGAGCACTATCAGGACTTTGACAAGAACAGTGTC
CGGGACATCACGGGTGCCCTGTTCAAGCACAGCAAGAAGGGGCCTAGAGCCAGCGGCAAC
CTCATCCCACAGGAGAAGATTGTCAACCTTGTCAATGACATCTTTGGAGCAGGATTTGAC
ACAGTCACCACAGCCATCTCCTGGAGCCTCATGTACCTTGTGACCAAGCCTGAGATACAG
AGGAAGATCCAGAAGGAGCTGGACACTGTGATTGGCAGGGAGCGGCGGCCCCGGCTCTCT
GACAGACCCCAGCTGCCCTACTTGGAGGCCTTCATCCTGGAGACCTTCCGACACTCCTCC
TTCTTGCCCTTCACCATCCCCCACAGCACAACAAGGGACACAACGCTGAATGGCTTCTAC
ATCCCCAAGAAATGCTGTGTCTTCGTAAACCAGTGGCAGGTCAACCATGACCCAGAGCTG
TGGGAGGACCCCTCTGAGTTCCGGCCTGAGCGGTTCCTCACCGCCGATGGCACTGCCATT
AACAAGCCCTTGAGTGAGAAGATGATGCTGTTTGGCATGGGCAAGCGCCGGTGTATCGGG
GAAGTCCTGGCCAAGTGGGAGATCTTCCTCTTCCTGGCCATCCTGCTACAGCAACTGGAG
TTCAGCGTGCCGCCGGGCGTGAAAGTCGACCTGACCCCCATCTACGGGCTGACCATGAAG
CACGCCCGCTGTGAACATGTCCAGGCGCGGCTGCGCTTCTCCATCAATTGA
Chromosome Location
15
Locus
15q24
External Identifiers
ResourceLink
UniProtKB IDP05177
UniProtKB Entry NameCP1A2_HUMAN
GenBank Gene IDZ00036
GenAtlas IDCYP1A2
HGNC IDHGNC:2596
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00176Fluvoxamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00188Bortezomibapproved, investigationalnosubstrateinhibitorDetails
DB00201CaffeineapprovedunknownsubstrateinhibitorDetails
DB00261AnagrelideapprovedunknownsubstrateDetails
DB00262CarmustineapprovedunknownsubstrateDetails
DB00268Ropiniroleapproved, investigationalunknownsubstrateinhibitorDetails
DB00277TheophyllineapprovedunknownsubstrateinhibitorDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00286Conjugated estrogensapprovedunknownsubstrateinhibitorDetails
DB00296RopivacaineapprovedunknownsubstrateDetails
DB00315Zolmitriptanapproved, investigationalunknownsubstrateDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB00321AmitriptylineapprovedunknownsubstrateinhibitorDetails
DB00334Olanzapineapproved, investigationalunknownsubstrateinhibitorDetails
DB00363ClozapineapprovedunknownsubstrateinhibitorDetails
DB00365GrepafloxacinwithdrawnunknownsubstrateDetails
DB00370MirtazapineapprovedunknownsubstrateinhibitorDetails
DB00379MexiletineapprovedunknownsubstrateinhibitorDetails
DB00382TacrinewithdrawnunknownsubstrateDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00476DuloxetineapprovedunknownsubstrateDetails
DB00499FlutamideapprovedunknownsubstrateinhibitorDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB00537Ciprofloxacinapproved, investigationalunknowninhibitorDetails
DB00540NortriptylineapprovedunknownsubstrateDetails
DB00544FluorouracilapprovedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateinhibitorDetails
DB00655EstroneapprovedunknownsubstrateDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorDetails
DB00682WarfarinapprovedunknownsubstrateDetails
DB00697TizanidineapprovedunknownsubstrateDetails
DB00740Riluzoleapproved, investigationalunknownsubstrateDetails
DB00744Zileutonapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00829Diazepamapproved, illicit, vet_approvedunknownsubstrateinhibitorDetails
DB00851Dacarbazineapproved, investigationalunknownsubstrateDetails
DB00863RanitidineapprovedunknownsubstrateinhibitorDetails
DB00904OndansetronapprovedunknownsubstrateinhibitorDetails
DB00924CyclobenzaprineapprovedunknownsubstrateDetails
DB00978LomefloxacinapprovedunknownsubstrateinhibitorDetails
DB00980Ramelteonapproved, investigationalunknownsubstrateDetails
DB00998Frovatriptanapproved, investigationalunknownsubstrateDetails
DB01002LevobupivacaineapprovedunknownsubstrateDetails
DB01012CinacalcetapprovedunknownsubstrateDetails
DB01094HesperetinapprovedunknownsubstrateDetails
DB01097Leflunomideapproved, investigationalunknownsubstrateDetails
DB01100PimozideapprovedunknownsubstrateDetails
DB01137Levofloxacinapproved, investigationalunknowninhibitorDetails
DB01165OfloxacinapprovedunknowninhibitorDetails
DB01182PropafenoneapprovedunknownsubstrateinhibitorDetails
DB01242Clomipramineapproved, vet_approvedunknownsubstrateDetails
DB00969Alosetronapproved, withdrawnunknownsubstrateDetails
DB01367RasagilineapprovedunknownsubstrateDetails
DB00213PantoprazoleapprovedunknownsubstrateinducerDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateDetails
DB00467EnoxacinapprovedunknowninhibitorDetails
DB00477Chlorpromazineapproved, vet_approvedunknownsubstrateDetails
DB00487PefloxacinapprovedunknowninhibitorDetails
DB00501CimetidineapprovedunknowninhibitorDetails
DB00532Mephenytoininvestigational, withdrawnunknownsubstrateDetails
DB00533Rofecoxibinvestigational, withdrawnunknownsubstrateinhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00730Thiabendazoleapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00908QuinidineapprovedunknowninhibitorDetails
DB00967Desloratadineapproved, investigationalunknowninhibitorDetails
DB00972AzelastineapprovedunknownsubstrateDetails
DB00976TelithromycinapprovedunknownsubstrateDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01045RifampicinapprovedunknowninducerDetails
DB01059NorfloxacinapprovedunknowninhibitorDetails
DB01418AcenocoumarolapprovedunknownsubstrateDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00377Palonosetronapproved, investigationalunknownsubstrateDetails
DB05708GTS-21investigationalunknownDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownsubstrateinhibitorDetails
DB05271RotigotineapprovedunknownsubstrateinhibitorDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorDetails
DB00619ImatinibapprovedunknownsubstrateDetails
DB00468QuinineapprovedunknownsubstrateinhibitorinducerDetails
DB01142DoxepinapprovedunknownsubstrateDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownsubstrateDetails
DB00564Carbamazepineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB00951IsoniazidapprovedunknowninhibitorDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01435AntipyrineapprovedunknownsubstrateDetails
DB01118Amiodaroneapproved, investigationalunknownsubstrateinhibitorDetails
DB00675TamoxifenapprovedunknownsubstrateDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00568CinnarizineapprovedunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB01075DiphenhydramineapprovedunknownsubstrateDetails
DB00788Naproxenapproved, vet_approvedunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB00553MethoxsalenapprovedunknowninhibitorDetails
DB01388MibefradilwithdrawnunknowninhibitorDetails
DB00030Insulin Humanapproved, investigationalunknowninducerDetails
DB00046Insulin LisproapprovedunknowninducerDetails
DB00047Insulin GlargineapprovedunknowninducerDetails
DB00071Insulin PorkapprovedunknowninducerDetails
DB01306Insulin AspartapprovedunknowninducerDetails
DB01307Insulin DetemirapprovedunknowninducerDetails
DB01309Insulin GlulisineapprovedunknowninducerDetails
DB00745Modafinilapproved, investigationalunknowninhibitorinducerDetails
DB00607NafcillinapprovedunknowninducerDetails
DB06732beta-NaphthoflavoneexperimentalunknowninducerDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB01223AminophyllineapprovedunknownsubstrateinhibitorDetails
DB06216AsenapineapprovedunknownsubstrateDetails
DB00195BetaxololapprovedunknownsubstrateDetails
DB04574Estrone sulfateapprovedunknownsubstrateDetails
DB00629GuanabenzapprovedunknownsubstrateDetails
DB01623ThiothixeneapprovedunknownsubstrateDetails
DB00831TrifluoperazineapprovedunknownsubstrateDetails
DB00357AminoglutethimideapprovedunknowninducerDetails
DB01174PhenobarbitalapprovedunknowninducerDetails
DB00794Primidoneapproved, vet_approvedunknowninducerDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB01241GemfibrozilapprovedunknowninhibitorDetails
DB00752TranylcypromineapprovedunknowninhibitorDetails
DB01087PrimaquineapprovedunknownsubstrateinhibitorinducerDetails
DB00758Clopidogrelapproved, nutraceuticalunknownsubstrateDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01628Etoricoxibapproved, investigationalunknownsubstrateinhibitorDetails
DB01645GenisteininvestigationalunknownsubstrateDetails
DB074532-PHENYL-4H-BENZO[H]CHROMEN-4-ONEexperimentalunknownDetails
DB02709Resveratrolexperimental, investigationalunknownsubstrateinhibitorinducerDetails
DB00518Albendazoleapproved, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00523Alitretinoinapproved, investigationalunknowninhibitorDetails
DB01217Anastrozoleapproved, investigationalunknowninhibitorDetails
DB00673Aprepitantapproved, investigationalunknownsubstrateDetails
DB00572Atropineapproved, vet_approvedunknowninhibitorDetails
DB01558Bromazepamapproved, illicitunknownsubstrateDetails
DB01200Bromocriptineapproved, investigationalunknowninhibitorDetails
DB00297Bupivacaineapproved, investigationalunknownsubstrateDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB01156BupropionapprovedunknownsubstrateDetails
DB00604Cisaprideapproved, investigational, withdrawnunknownsubstrateDetails
DB00215CitalopramapprovedunknowninhibitorDetails
DB01211ClarithromycinapprovedunknowninhibitorDetails
DB01407Clenbuterolapproved, vet_approvedunknownsubstrateDetails
DB01013Clobetasol propionateapprovedunknowninhibitorDetails
DB00882Clomifeneapproved, investigationalunknowninhibitorDetails
DB00694DaunorubicinapprovedunknownsubstrateDetails
DB00705DelavirdineapprovedunknowninhibitorDetails
DB01151DesipramineapprovedunknownsubstrateDetails
DB01191Dexfenfluramineapproved, illicit, withdrawnunknownsubstrateinhibitorDetails
DB00917DinoprostoneapprovedunknownsubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00988DopamineapprovedunknowninhibitorDetails
DB00625Efavirenzapproved, investigationalunknowninhibitorDetails
DB00668Epinephrineapproved, vet_approvedunknowninhibitorDetails
DB00696ErgotamineapprovedunknownsubstrateDetails
DB00199Erythromycinapproved, vet_approvednoinhibitorDetails
DB00898EthanolapprovedunknownsubstrateDetails
DB00773EtoposideapprovedunknownsubstrateDetails
DB01544Flunitrazepamapproved, illicitunknownsubstrateDetails
DB00623FluphenazineapprovedunknowninhibitorDetails
DB01095FluvastatinapprovedunknowninhibitorDetails
DB00400Griseofulvinapproved, vet_approvedunknowninducerDetails
DB01355HexobarbitalapprovedunknownsubstrateDetails
DB00724Imiquimodapproved, investigationalunknownsubstrateDetails
DB01029Irbesartanapproved, investigationalunknowninhibitorDetails
DB00448Lansoprazoleapproved, investigationalunknowninducerDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB00678LosartanapprovedunknowninhibitorDetails
DB01283Lumiracoxibapproved, investigationalunknownsubstrateDetails
DB00772Malathionapproved, investigationalunknownsubstrateDetails
DB00934MaprotilineapprovedunknownsubstrateDetails
DB00737MeclizineapprovedunknowninhibitorDetails
DB00170Menadioneapproved, nutraceuticalunknownsubstrateinducerDetails
DB00333MethadoneapprovedunknownsubstrateDetails
DB01028Methoxyfluraneapproved, vet_approvedunknownsubstrateDetails
DB06148MianserinapprovedunknownsubstrateDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01171MoclobemideapprovedunknowninhibitorDetails
DB00220NelfinavirapprovedunknowninhibitorDetails
DB00238NevirapineapprovedunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateinducerDetails
DB06712NilvadipineapprovedunknowninhibitorDetails
DB00401NisoldipineapprovedunknowninhibitorDetails
DB00325NitroprussideapprovedunknowninhibitorDetails
DB00368NorepinephrineapprovedunknowninhibitorDetails
DB00526Oxaliplatinapproved, investigationalunknownsubstrateDetails
DB00738PentamidineapprovedunknownsubstrateDetails
DB00806Pentoxifyllineapproved, investigationalunknownsubstrateinhibitorDetails
DB00850PerphenazineapprovedunknownsubstrateinhibitorDetails
DB00191Phentermineapproved, illicitunknowninhibitorDetails
DB00388PhenylephrineapprovedunknowninducerDetails
DB00397Phenylpropanolamineapproved, vet_approved, withdrawnunknowninhibitorDetails
DB01058Praziquantelapproved, vet_approvedunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateDetails
DB01131ProguanilapprovedunknownsubstrateDetails
DB00818Propofolapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00339PyrazinamideapprovedunknownsubstrateDetails
DB01129Rabeprazoleapproved, investigationalunknowninducerDetails
DB00615RifabutinapprovedunknownsubstrateDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinducerDetails
DB00412Rosiglitazoneapproved, investigationalunknowninhibitorDetails
DB00778Roxithromycinapproved, withdrawnunknowninhibitorDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB00605SulindacapprovedunknowninhibitorDetails
DB01079Tegaserodinvestigational, withdrawnunknowninhibitorDetails
DB01405TemafloxacinwithdrawnunknownsubstrateinhibitorDetails
DB00300Tenofovir disoproxilapproved, investigationalunknowninhibitorDetails
DB01412TheobromineapprovedunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB00679ThioridazinewithdrawnunknownsubstrateinhibitorDetails
DB00208TiclopidineapprovedunknowninhibitorDetails
DB01007TioconazoleapprovedunknowninhibitorDetails
DB01056TocainideapprovedunknowninhibitorDetails
DB00539Toremifeneapproved, investigationalunknownsubstrateDetails
DB00384TriamtereneapprovedunknownsubstrateinhibitorDetails
DB00313Valproic Acidapproved, investigationalunknowninhibitorDetails
DB00549Zafirlukastapproved, investigationalunknowninhibitorDetails
DB00246ZiprasidoneapprovedunknownsubstrateDetails
DB01403MethotrimeprazineapprovedunknowninhibitorDetails
DB01303OxtriphyllineapprovedunknownsubstrateDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB00418Secobarbitalapproved, vet_approvedunknowninducerDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB01166CilostazolapprovedunknownsubstrateDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateDetails
DB01621PipotiazineapprovedunknownsubstrateDetails
DB06210EltrombopagapprovedunknownsubstrateinhibitorDetails
DB06413Armodafinilapproved, investigationalunknowninducerDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB00953RizatriptanapprovedunknownsubstrateDetails
DB00918Almotriptanapproved, investigationalunknownsubstrateDetails
DB06594Agomelatineapproved, investigationalunknowninhibitorDetails
DB00974Edetic Acidapproved, vet_approvedunknowninhibitorDetails
DB06770Benzyl alcoholapprovedunknownsubstrateDetails
DB06774CapsaicinapprovedunknowninducerDetails
DB04920ClevidipineapprovedunknownsubstrateDetails
DB04816Danthroninvestigational, withdrawnunknowninducerDetails
DB00633Dexmedetomidineapproved, vet_approvedunknowninhibitorDetails
DB06235VadimezaninvestigationalunknownsubstrateDetails
DB00461NabumetoneapprovedunknownsubstrateDetails
DB06803Niclosamideapproved, vet_approvedunknowninhibitorDetails
DB00435Nitric OxideapprovedunknownsubstrateDetails
DB06820SulconazoleapprovedunknowninhibitorDetails
DB00428StreptozocinapprovedunknowninducerDetails
DB04946IloperidoneapprovedunknownsubstrateDetails
DB06589PazopanibapprovedunknownsubstrateDetails
DB08867UlipristalapprovednosubstrateDetails
DB04871LorcaserinapprovednosubstrateDetails
DB08864RilpivirineapprovedunknowninducerDetails
DB08881VemurafenibapprovedunknowninhibitorDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08910PomalidomideapprovedunknownsubstrateDetails
DB00207AzithromycinapprovedunknowninhibitorDetails
DB06290SimeprevirapprovednoinhibitorDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB00951IsoniazidapprovedunknownDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB09570IxazomibapprovedunknownsubstrateDetails
DB09330OsimertinibapprovednoinducerDetails
DB06412Oxymetholoneapproved, illicitunknowninhibitorDetails
DB09456Insulin BeefapprovedunknowninducerDetails
DB06769Bendamustineapproved, investigationalnosubstrateDetails
DB00787AciclovirapprovedunknowninhibitorDetails
DB00714Apomorphineapproved, investigationalunknowninhibitorDetails
DB01072Atazanavirapproved, investigationalunknowninhibitorDetails
DB00389CarbimazoleapprovedunknowninhibitorDetails
DB00822DisulfiramapprovedunknowninhibitorDetails
DB00494Entacaponeapproved, investigationalunknowninhibitorDetails
DB00196FluconazoleapprovedunknowninhibitorDetails
DB08909Glycerol PhenylbutyrateapprovedunknowninhibitorDetails
DB00105Interferon Alfa-2b, RecombinantapprovedunknowninhibitorDetails
DB00033Interferon gamma-1bapproved, investigationalunknowninhibitorDetails
DB01357MestranolapprovedunknowninhibitorDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorDetails
DB01149Nefazodoneapproved, withdrawnunknowninhibitorDetails
DB05990Obeticholic acidapprovedunknowninhibitorDetails
DB01173OrphenadrineapprovedunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB00008Peginterferon alfa-2aapproved, investigationalunknowninhibitorDetails
DB00022Peginterferon alfa-2bapprovedunknowninhibitorDetails
DB06819Phenylbutyric acidapproved, investigationalunknowninhibitorDetails
DB00577Valaciclovirapproved, investigationalunknowninhibitorDetails
DB09317Synthetic Conjugated Estrogens, AapprovedunknowninhibitorDetails
DB12332Rucaparibapproved, investigationalyessubstrateDetails
DB11737Icotinibapproved, investigationalunknownsubstrateDetails
DB05219CrisaboroleapprovedunknowninhibitorDetails
DB12161Deutetrabenazineapproved, investigationalyessubstrateDetails
DB06595MidostaurinapprovedunknowninhibitorinducerDetails
DB05015Belinostatapproved, investigationalunknowninducerDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB01685TopiroxostatapprovedunknowninhibitorDetails
DB09120ZucapsaicinapprovedunknowninhibitorDetails
DB09118StiripentolapprovedunknownsubstrateDetails
DB09198LobeglitazoneapprovednoinhibitorDetails
DB09167DosulepinapprovedunknowninhibitorDetails
DB09238ManidipineapprovedunknowninhibitorDetails
DB12026VoxilaprevirapprovednosubstrateDetails
DB13874EnasidenibapprovedunknownsubstrateinhibitorDetails
DB13878PibrentasvirapprovedunknowninhibitorDetails
DB13879GlecaprevirapprovedunknowninhibitorDetails