Cytochrome P450 3A2
Details
- Name
- Cytochrome P450 3A2
- Synonyms
- 1.14.14.1
- Cyp3a-2
- Cyp3a11
- CYPIIIA2
- Cytochrome P450-PCN2
- Cytochrome P450/6-beta-A
- Testosterone 6-beta-hydroxylase
- Gene Name
- Cyp3a2
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0013302|Cytochrome P450 3A2 MDLLSALTLETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYKGLGRF DMECYKKYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSV AKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYS MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICM FPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQS VIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMV LNETLRLYPIGNRLERVCKKDIELDGLFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERF SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSR QAILEPEKPIVLKVLPRDAVINGA
- Number of residues
- 504
- Molecular Weight
- 57731.215
- Theoretical pI
- Not Available
- GO Classification
- Functionsaromatase activity / demethylase activity / heme binding / iron ion binding / monooxygenase activity / testosterone 6-beta-hydroxylase activityProcessesdrug metabolic process / oxidative demethylationComponentsendoplasmic reticulum membrane
- General Function
- Testosterone 6-beta-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0013303|Cytochrome P450 3A2 (Cyp3a2) ATGGACCTGCTTTCAGCTCTCACACTGGAAACCTGGGTCCTCCTGGCAGTCATCCTGGTG CTTCTCTACCGACTTGGAACCCATAGACATGGAATTTTTAAGAAACAAGGAATTCCTGGG CCAAAACCTCTGCCCTTTTTAGGCACTGTGCTGAATTACTACAAGGGCTTAGGGAGATTT GACATGGAGTGCTATAAAAAGTATGGAAAAATATGGGGGTTGTTTGATGGTCAAACGCCT GTGTTTGCCATCATGGACACAGAGATGATTAAGAATGTACTAGTGAAGGAATGCTTTTCT GTCTTCACAAACCGGCGGGATTTTGGCCCAGTGGGGATTATGGGGAAAGCTGTCTCTGTA GCTAAGGATGAGGAGTGGAAGAGATATAGAGCCTTGCTGTCCCCCACGTTCACCAGTGGA AGACTCAAGGAGATGTTCCCCATCATTGAACAGTATGGAGACATTTTGGTAAAGTACTTG AAGCAAGAGGCGGAGACAGGCAAGCCTGTCACCATGAAAAAAGTGTTTGGTGCCTACAGC ATGGATGTGATCACCAGCACATCATTTGGAGTGAACGTCGATTCCCTTAACAACCCAAAG GATCCTTTTGTGGAGAAAACCAAGAAATTGTTAAGATTTGACTTTTTTGATCCGTTGTTC TTGTCAGTAGTACTCTTTCCATTCCTCACCCCAATATATGAGATGCTAAATATCTGCATG TTCCCAAAGGATTCAATAGCATTTTTCCAAAAATTTGTGCACAGAATAAAGGAAACCCGT CTGGATTCTAAGCATAAGCACCGAGTGGATTTTCTCCAGCTGATGCTGAACGCTCATAAT AATTCCAAAGACGAAGTGTCTCATAAAGCCCTGTCTGATGTTGAAATCATAGCCCAGTCA GTTATCTTTATTTTTGCTGGCTATGAAACCACCAGCAGCACACTCTCCTTTGTCTTGTAT TTCCTGGCCACTCACCCTGATATTCAGAAGAAACTGCAGGAGGAGATCGATGGGGCCCTG CCGAGTAAGGCACCTCCTACCTACGATATTGTGATGGAAATGGAATACCTGGATATGGTG TTGAATGAAACTCTCAGATTGTATCCAATTGGTAATAGACTTGAGAGAGTCTGTAAAAAA GATATAGAACTTGATGGTTTGTTTATACCCAAAGGGTCAGTAGTGACGATTCCAACATAT GCTCTTCATCATGACCCACAGCACTGGCCAAAGCCTGAGGAATTTCATCCAGAAAGGTTT AGCAAGGAGAACAAGGGAAGCATTCATCCTTATGTATATCTGCCCTTTGGAAATGGACCC AGGAACTGCATTGACATGAGGTTTGCTCTCATGAATATGAAACTCGCTCTCACTAAAGTT CTGCAAAACTTCTCCTTCCAGCCTTGCAAGGAAACACAGATACCTCTGAAATTGAGTAGA CAAGCAATTCTTGAACCAGAAAAACCCATTGTTCTAAAGGTTCTGCCACGGGATGCAGTC ATAAATGGAGCCTGA
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P05183 UniProtKB Entry Name CP3A2_RAT - General References
- Gonzalez FJ, Song BJ, Hardwick JP: Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Mol Cell Biol. 1986 Aug;6(8):2969-76. [Article]
- Miyata M, Nagata K, Yamazoe Y, Kato R: A gene structure of testosterone 6 beta-hydroxylase (P450IIIA). Biochem Biophys Res Commun. 1991 May 31;177(1):68-73. [Article]
- Miyata M, Nagata K, Shimada M, Yamazoe Y, Kato R: Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. Arch Biochem Biophys. 1994 Nov 1;314(2):351-9. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Telhada MB, Pereira TM, Lechner MC: Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Arch Biochem Biophys. 1992 Nov 1;298(2):715-25. [Article]
- Nagata K, Gonzalez FJ, Yamazoe Y, Kato R: Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. J Biochem. 1990 May;107(5):718-25. [Article]
- Cooper KO, Reik LM, Jayyosi Z, Bandiera S, Kelley M, Ryan DE, Daniel R, McCluskey SA, Levin W, Thomas PE: Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys. 1993 Mar;301(2):345-54. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB08834 Tauroursodeoxycholic acid approved, investigational unknown inducer Details DB13975 Black cohosh experimental no inhibitorinducer Details DB13746 Bioallethrin approved, experimental no substrate Details DB01645 Genistein investigational unknown substrate Details DB00869 Dorzolamide approved no substrate Details