Gag polyprotein

Details

Name
Gag polyprotein
Synonyms
  • Pr55Gag
Gene Name
gag
Organism
SIV-mac
Amino acid sequence
>lcl|BSEQ0005345|Gag polyprotein
MGARNAVLSGKKADELEKIRLRPGGKKKYMLKHVVWAANELDRFGLAESLLENKEGCQKI
LSVLAPLVPTGSENLKSLYNTVCVIWCIHAEEKVKHTEEAKQIVQRHLVVETGTAETMPK
TSRPTAPSSGRGGNYPVQQIGGNYVHLPLSPRTLNAWVKLIEEKKFGAEVVPGFQALSEG
CTPYDINQMLNCVGDHQAAMQIIRDIINEEAADWDLQHPQPAPQQGQLREPSGSDIAGTT
SSVDEQIQWMYRQQNPIPVGNIYRRWIQLRLQKCVRMYNPINILDVKQRPKEPFQSYVDR
FYKSLRAEQTDAAVKNWMTQTLLIQNANPDCKLVLKGLGVNPTLEEMLTACQGVGGPGQK
ARLMAEALKEALRPVPTPFAAAQQRGPRKPIKCWNCGKEGHSARQCRAPRRQRCWKCGKM
DHVMAKCPDRQAGFLGLGPWGKKPRNFPMAQVHQGLTPTAPPEDPAVDLLKNYMQLGKQQ
RESREKPYKEVTEDLLHLNSLFGGDQ
Number of residues
506
Molecular Weight
56725.035
Theoretical pI
9.42
GO Classification
Functions
RNA binding / structural molecule activity / zinc ion binding
Processes
viral budding via host ESCRT complex / viral release from host cell
Components
host cell cytoplasm / host cell nucleus / host cell plasma membrane / membrane / viral nucleocapsid
General Function
Zinc ion binding
Specific Function
Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu (By similarity).Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Virion
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP05893
UniProtKB Entry NameGAG_SIVMK
General References
  1. Franchini G, Gurgo C, Guo HG, Gallo RC, Collalti E, Fargnoli KA, Hall LF, Wong-Staal F, Reitz MS Jr: Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature. 1987 Aug 6-12;328(6130):539-43. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails