30 kDa immediate-early protein 2

Details

Name

30 kDa immediate-early protein 2

Synonyms

• IE2

Gene Name

UL122

Organism

Human cytomegalovirus (strain Towne)

Amino acid sequence

>lcl|BSEQ0051578|30 kDa immediate-early protein 2
MLPLIKQEDIKPEPDFTIQYRNKIIDTAGCIVISDSEEEQGEEVETRGATASSPSTGSGT
PRVTSPTHPLSQMNHPPLPDPLGRPDEDSSSSSSSCSSASDSESESEEMKCSSGGGASVT
SSHHGRGGFGGAASSSLLSCGHQSSGGASTGPRKKKSKRISELDNEKVRNIMKDKNTPFC
TPNVQTRRGRVKIDEVSRMFRNTNRSLEYKNLPFTIPSMHQVLDEAIKACKTMQVNNKGI
QIIYTRNHEVKSEVDAVRCRLGTMCTWPSPLPSSWSTPCP

Number of residues

280

Molecular Weight

30328.565

Theoretical pI

Not Available

GO Classification

Processes

regulation of transcription, DNA-templated

General Function

Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.

Specific Function

Not Available

Pfam Domain Function

• Herpes_IE2_3 (PF03361)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P06434
UniProtKB Entry Name	VIE3_HCMVT

General References

1. Stenberg RM, Witte PR, Stinski MF: Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. J Virol. 1985 Dec;56(3):665-75. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB06759	Fomivirsen	approved, investigational, withdrawn	yes	antisense oligonucleotide	Details