Penicillin G acylase

Details

Name
Penicillin G acylase
Synonyms
  • 3.5.1.11
  • Penicillin G amidase
  • Penicillin G amidohydrolase
Gene Name
pac
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0012652|Penicillin G acylase
MKNRNRMIVNCVTASLMYYWSLPALAEQSSSEIKIVRDEYGMPHIYANDTWHLFYGYGYV
VAQDRLFQMEMARRSTQGTVAEVLGKDFVKFDKDIRRNYWPDAIRAQIAALSPEDMSILQ
GYADGMNAWIDKVNTNPETLLPKQFNTFGFTPKRWEPFDVAMIFVGTMANRFSDSTSEID
NLALLTALKDKYGVSQGMAVFNQLKWLVNPSAPTTIAVQESNYPLKFNQQNSQTAALLPR
YDLPAPMLDRPAKGADGALLALTAGKNRETIAAQFAQGGANGLAGYPTTSNMWVIGKSKA
QDAKAIMVNGPQFGWYAPAYTYGIGLHGAGYDVTGNTPFAYPGLVFGHNGVISWGSTAGF
GDDVDIFAERLSAEKPGYYLHNGKWVKMLSREETITVKNGQAETFTVWRTVHGNILQTDQ
TTQTAYAKSRAWDGKEVASLLAWTHQMKAKNWQEWTQQAAKQALTINWYYADVNGNIGYV
HTGAYPDRQSGHDPRLPVPGTGKWDWKGLLPFEMNPKVYNPQSGYIANWNNSPQKDYPAS
DLFAFLWGGADRVTEIDRLLEQKPRLTADQAWDVIRQTSRQDLNLRLFLPTLQAATSGLT
QSDPRRQLVETLTRWDGINLLNDDGKTWQQPGSAILNVWLTSMLKRTVVAAVPMPFDKWY
SASGYETTQDGPTGSLNISVGAKILYEAVQGDKSPIPQAVDLFAGKPQQEVVLAALEDTW
ETLSKRYGNNVSNWKTPAMALTFRANNFFGVPQAAAEETRHQAEYQNRGTENDMIVFSPT
TSDRPVLAWDVVAPGQSGFIAPDGTVDKHYEDQLKMYENFGRKSLWLTKQDVEAHKESQE
VLHVQR
Number of residues
846
Molecular Weight
94642.025
Theoretical pI
6.59
GO Classification
Functions
metal ion binding / penicillin amidase activity
Processes
antibiotic biosynthetic process / response to antibiotic
Components
periplasmic space
General Function
Penicillin amidase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP06875
UniProtKB Entry NamePAC_ECOLX
GenBank Protein ID147063
GenBank Gene IDM15950
General References
  1. Schumacher G, Sizmann D, Haug H, Buckel P, Bock A: Penicillin acylase from E. coli: unique gene-protein relation. Nucleic Acids Res. 1986 Jul 25;14(14):5713-27. [Article]
  2. Oh SJ, Kim YC, Park YW, Min SY, Kim IS, Kang HS: Complete nucleotide sequence of the penicillin G acylase gene and the flanking regions, and its expression in Escherichia coli. Gene. 1987;56(1):87-97. [Article]
  3. Oliver G, Valle F, Rosetti F, Gomez-Pedrozo M, Santamaria P, Gosset G, Bolivar F: A common precursor for the two subunits of the penicillin acylase from Escherichia coli ATCC11105. Gene. 1985;40(1):9-14. [Article]
  4. Valle F, Gosset G, Tenorio B, Oliver G, Bolivar F: Characterization of the regulatory region of the Escherichia coli penicillin acylase structural gene. Gene. 1986;50(1-3):119-22. [Article]
  5. Bruns W, Hoppe J, Tsai H, Bruning HJ, Maywald F, Collins J, Mayer H: Structure of the penicillin acylase gene from Escherichia coli: a periplasmic enzyme that undergoes multiple proteolytic processing. J Mol Appl Genet. 1985;3(1):36-44. [Article]
  6. Slade A, Horrocks AJ, Lindsay CD, Dunbar B, Virden R: Site-directed chemical conversion of serine to cysteine in penicillin acylase from Escherichia coli ATCC 11105. Effect on conformation and catalytic activity. Eur J Biochem. 1991 Apr 10;197(1):75-80. [Article]
  7. Sizmann D, Keilmann C, Bock A: Primary structure requirements for the maturation in vivo of penicillin acylase from Escherichia coli ATCC 11105. Eur J Biochem. 1990 Aug 28;192(1):143-51. [Article]
  8. Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PC: Penicillin acylase has a single-amino-acid catalytic centre. Nature. 1995 Jan 19;373(6511):264-8. [Article]
  9. McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA: Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism. J Mol Biol. 2001 Oct 12;313(1):139-50. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07331p-Nitrophenylacetic acidexperimentalunknownDetails
DB017022-(3,4-Dihydroxyphenyl)Acetic AcidexperimentalunknownDetails
DB081932-(3-NITROPHENYL)ACETIC ACIDexperimentalunknownDetails
DB08327Homogentisic acidexperimentalunknownDetails
DB08559N-[(2S,4S,6R)-2-(dihydroxymethyl)-4-hydroxy-3,3-dimethyl-7-oxo-4lambda~4~-thia-1-azabicyclo[3.2.0]hept-6-yl]-2-phenylacetamideexperimentalunknownDetails