Outer membrane usher protein PapC
Details
- Name
- Outer membrane usher protein PapC
- Synonyms
- Not Available
- Gene Name
- papC
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0012768|Outer membrane usher protein PapC MKDRIPFAVNNITCVILLSLFCNAASAVEFNTDVLDAADKKNIDFTRFSEAGYVLPGQYL LDVIVNGQSISPASLQISFVEPALSGDKAEKKLPQACLTSDMVRLMGLTAESLDKVVYWH DGQCADFHGLPGVDIRPDTGAGVLRINMPQAWLEYSDATWLPPSRWDDGIPGLMLDYNLN GTVSRNYQGGDSHQFSYNGTVGGNLGPWRLRADYQGSQEQSRYNGEKTTNRNFTWSRFYL FRAIPRWRANLTLGENNINSDIFRSWSYTGASLESDDRMLPPRLRGYAPQITGIAETNAR VVVSQQGRVLYDSMVPAGPFSIQDLDSSVRGRLDVEVIEQNGRKKTFQVDTASVPYLTRP GQVRYKLVSGRSRGYGHETEGPVFATGEASWGLSNQWSLYGGAVLAGDYNALAAGAGWDL GVPGTLSADITQSVARIEGERTFQGKSWRLSYSKRFDNADADITFAGYRFSERNYMTMEQ YLNARYRNDYSSREKEMYTVTLNKNVADWNTSFNLQYSRQTYWDIRKTDYYTVSVNRYFN VFGLQGVAVGLSASRSKYLGRDNDSAYLRISVPLGTGTASYSGSMSNDRYVNMAGYTDTF NDGLDSYSLNAGLNSGGGLTSQRQINAYYSHRSPLANLSANIASLQKGYTSFGVSASGGA TITGKGAALHAGGMSGGTRLLVDTDGVGGVPVDGGQVVTNRWGTGVVTDISSYYRNTTSV DLKRLPDDVEATRSVVESALTEGAIGYRKFSVLKGKRLFAILRLADGSQPPFGASVTSEK GRELGMVADEGLAWLSGVTPGETLSVNWDGKIQCQVNVPETAISDQQLLLPCTPQK
- Number of residues
- 836
- Molecular Weight
- 91508.325
- Theoretical pI
- 6.54
- GO Classification
- Functionstransporter activityComponentscell outer membrane / integral component of membrane
- General Function
- Transporter activity
- Specific Function
- Involved in the export and assembly of pili subunits across the outer membrane. Forms a hexameric ring-shaped pore in the outer bacterial membrane. The 2 nanometer-diameter pore allows the passage of the thin tip fibrillum. As for the rod, it probably unwinds into linear fibers which would therefore be narrow enough to pass through the pore.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0007607|2511 bp ATGAAAGACAGAATACCTTTTGCAGTCAACAATATTACCTGTGTGATATTGTTGTCTCTG TTTTGTAACGCAGCCAGTGCCGTTGAGTTTAATACAGATGTACTTGACGCAGCGGACAAG AAAAATATTGACTTCACCCGTTTTTCAGAAGCCGGCTATGTTCTGCCGGGGCAATATCTT CTGGATGTGATTGTTAACGGGCAAAGTATTTCTCCCGCATCGTTACAGATTTCATTTGTT GAACCTGCGTTGTCAGGAGATAAGGCAGAAAAAAAATTGCCGCAGGCCTGTCTGACATCA GATATGGTCAGACTGATGGGGTTAACAGCAGAATCTCTGGATAAAGTTGTTTACTGGCAT GATGGTCAGTGTGCGGATTTTCATGGGTTGCCGGGAGTGGATATTCGTCCTGATACCGGA GCGGGCGTATTACGCATCAATATGCCGCAGGCCTGGCTTGAGTATTCTGATGCCACCTGG CTGCCTCCCTCACGCTGGGACGACGGCATTCCCGGACTGATGCTGGATTATAACCTCAAC GGGACGGTTTCCCGTAATTATCAGGGAGGAGACTCTCATCAGTTCAGTTATAACGGGACT GTGGGGGGGAATCTGGGGCCCTGGCGCCTGCGGGCTGACTATCAGGGAAGCCAGGAGCAG AGCCGCTACAACGGGGAAAAAACGACAAACAGAAATTTCACATGGAGTCGCTTTTATCTG TTCCGTGCCATTCCACGATGGCGGGCAAACCTGACGCTGGGCGAGAATAATATCAACTCA GATATATTCCGGTCATGGAGTTATACGGGAGCCAGCCTGGAAAGCGATGACCGGATGCTG CCGCCCAGACTGCGAGGCTATGCACCGCAGATTACCGGGATTGCGGAGACTAATGCCCGT GTTGTGGTGTCGCAGCAGGGACGGGTGCTGTACGACTCGATGGTCCCCGCAGGGCCATTC AGTATTCAGGACCTGGACAGTTCAGTTCGCGGACGTCTTGATGTTGAGGTTATTGAACAG AACGGACGGAAGAAAACCTTTCAGGTCGATACGGCCTCGGTTCCTTATCTGACGCGTCCG GGACAGGTCCGGTACAAACTTGTCTCCGGTCGTTCCCGTGGATACGGGCATGAGACCGAA GGGCCTGTATTTGCGACCGGAGAGGCATCCTGGGGGCTCAGTAACCAGTGGTCGCTGTAT GGCGGGGCTGTGCTTGCCGGTGATTATAATGCACTGGCAGCCGGTGCCGGCTGGGACCTG GGTGTGCCGGGGACCCTTTCCGCTGATATCACGCAGTCAGTAGCCCGTATTGAGGGAGAG AGAACGTTTCAGGGAAAATCCTGGCGTCTGAGCTACTCCAAACGGTTTGATAATGCGGAT GCCGACATTACGTTCGCCGGGTATCGTTTCTCAGAGCGAAACTATATGACCATGGAGCAG TACCTGAACGCCCGCTACCGTAATGATTACAGCAGTCGGGAAAAAGAGATGTATACCGTT ACGCTGAATAAAAACGTGGCGGACTGGAACACCTCTTTTAACCTGCAGTCCGAAAACATT AAAGTAGCGGTTGACGCTCACCGTATAATAGTCCGTTTTCCGTATGTCCCAGTATGTCTG ACGGCTGTACTGCAGGGTGTGGCGGTTGGATTGTCAGCCTCAAGGTCTAAATATCTGGGG CGTGATAACGATTCTGCTTACCTGCGTATATCCGTGCCGCTGGGGACGGGGACAGCGAGC TACAGTGGCAGTATGAGTAATGACCGTTATGTGAATATGGCCGGCTACACTGACACGTTC AATGACGGTCTGGACAGCTACAGCCTGAACGCCGGCCTTAACAGTGGCGGTGGACTGACA TCGCAACGTCAGATTAATGCCTATTACAGTCATCGTAGTCCGCTGGCAAATTTGTCCGCG AATATTGCATCCCTGCAGAAAGGATATACGTCTTTCGGCGTCAGTGCTTCCGGTGGGGCA ACAATTACCGGAAAAGGTGCGGCGTTACATGCAGGGGGAATGTCCGGTGGAACACGTCTT CTTGTTGACACGGATGGTGTGGGAGGTGTACCGGTTGATGGCGGGCAGGTGGTGACAAAT CGCTGGGGAACGGGCGTGGTGACTGACATCAGCAGTTATTACCGGAATACAACCTCTGTT GACCTGAAGCGCTTACCGGATGATGTGGAAGCAACCCGTTCTGTTGTGGAATCGGCGCTG ACAGAAGGTGCCATTGGTTACCGGAAATTCAGCGTGCTTAAAGGGAAACGTCTGTTTGCA ATACTGCGTCTTGCTGATGGCTCTCAGCCCCCGTTTGGTGCCAGTGTAACCAGTGAAAAA GGCCGGGAACTGGGCATGGTGGCCGACGAAGGCCTTGCCTGGCTGAGTGGCGTGACGCCG GGGGAAACCCTGTCGGTAAACTGGGATGGAAAAATACAGTGTCAGGTAAATGTACCGGAG ACAGCAATATCTGACCAGCAGTTATTGCTTCCCTGTACGCCTCAGAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P07110 UniProtKB Entry Name PAPC_ECOLX GenBank Protein ID 747709 GenBank Gene ID Y00529 - General References
- Norgren M, Baga M, Tennent JM, Normark S: Nucleotide sequence, regulation and functional analysis of the papC gene required for cell surface localization of Pap pili of uropathogenic Escherichia coli. Mol Microbiol. 1987 Sep;1(2):169-78. [Article]
- Marklund BI, Tennent JM, Garcia E, Hamers A, Baga M, Lindberg F, Gaastra W, Normark S: Horizontal gene transfer of the Escherichia coli pap and prs pili operons as a mechanism for the development of tissue-specific adhesive properties. Mol Microbiol. 1992 Aug;6(16):2225-42. [Article]
- Thanassi DG, Stathopoulos C, Dodson K, Geiger D, Hultgren SJ: Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis. J Bacteriol. 2002 Nov;184(22):6260-9. [Article]
- Lindberg F, Tennent JM, Hultgren SJ, Lund B, Normark S: PapD, a periplasmic transport protein in P-pilus biogenesis. J Bacteriol. 1989 Nov;171(11):6052-8. [Article]
- Jacob-Dubuisson F, Striker R, Hultgren SJ: Chaperone-assisted self-assembly of pili independent of cellular energy. J Biol Chem. 1994 Apr 29;269(17):12447-55. [Article]
- Thanassi DG, Saulino ET, Lombardo MJ, Roth R, Heuser J, Hultgren SJ: The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3146-51. [Article]