Tubulin beta chain
Details
- Name
- Tubulin beta chain
- Synonyms
- TUBB5
- Tubulin beta-5 chain
- Gene Name
- TUBB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009963|Tubulin beta chain MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDATAEEEEDFGEEAEEEA
- Number of residues
- 444
- Molecular Weight
- 49670.515
- Theoretical pI
- 4.52
- GO Classification
- FunctionsGTP binding / GTPase activity / MHC class I protein binding / structural constituent of cytoskeleton / structural molecule activity / ubiquitin protein ligase bindingProcessescell division / cellular process / cytoskeleton-dependent intracellular transport / G2/M transition of mitotic cell cycle / microtubule-based process / mitotic cell cycle / movement of cell or subcellular component / natural killer cell mediated cytotoxicity / organelle organization / spindle assemblyComponentscell body / cytoplasmic ribonucleoprotein granule / cytoskeleton / cytosol / extracellular exosome / microtubule / nuclear envelope lumen / nucleus
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0009964|Tubulin beta chain (TUBB) ATGGGAGATGTGGGGCCGAGGTGGGCGAATTGGGATCCCTCCAGGTCAGGGGTTCGAGAC CATCCTGGGCAACAAAGCGAGACCCTCCCCCATGCCACGTTTCTACAAAAAATAAAATTC TGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGC GACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTT CCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCT TTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAAC TGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTA CGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGC GGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCT GATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTC GAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTAT TGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCA ACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTC CGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTC CCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAG TATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATG GCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGG ATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTAC TTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGC CTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGC ATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGC GAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCT GAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCC GAAGAGGAGGCCTAA
- Chromosome Location
- 6
- Locus
- 6p25
- External Identifiers
Resource Link UniProtKB ID P07437 UniProtKB Entry Name TBB5_HUMAN GenBank Protein ID 338695 GenBank Gene ID J00314 GenAtlas ID TUBB HGNC ID HGNC:20778 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00361 Vinorelbine approved, investigational yes antagonistinhibitor Details DB00541 Vincristine approved, investigational yes inhibitor Details DB00570 Vinblastine approved yes binder Details DB01394 Colchicine approved yes inhibitorbinder Details DB01873 Epothilone D investigational unknown Details DB03010 Patupilone experimental, investigational unknown Details DB05284 CA4P investigational unknown Details DB05147 CYT997 investigational unknown Details DB06042 ZEN-012 investigational unknown Details DB12334 Milataxel investigational unknown Details DB01179 Podofilox approved yes inhibitor Details DB11731 Depatuxizumab mafodotin investigational yes nucleotide exchange blocker Details DB09130 Copper approved, investigational unknown Details DB11638 Artenimol approved, experimental, investigational unknown ligand Details DB11641 Vinflunine approved, investigational yes inhibitor Details DB15534 Colchiceine approved, experimental unknown binder Details DB06137 Tirbanibulin approved, investigational yes inhibitor Details