Galactoside O-acetyltransferase

Details

Name
Galactoside O-acetyltransferase
Synonyms
  • 2.3.1.18
  • GAT
  • Thiogalactoside acetyltransferase
Gene Name
lacA
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0016416|Galactoside O-acetyltransferase
MNMPMTERIRAGKLFTDMCEGLPEKRLRGKTLMYEFNHSHPSEVEKRESLIKEMFATVGE
NAWVEPPVYFSYGSNIHIGRNFYANFNLTIVDDYTVTIGDNVLIAPNVTLSVTGHPVHHE
LRKNGEMYSFPITIGNNVWIGSHVVINPGVTIGDNSVIGAGSIVTKDIPPNVVAAGVPCR
VIREINDRDKHYYFKDYKVESSV
Number of residues
203
Molecular Weight
22798.89
Theoretical pI
6.72
GO Classification
Functions
galactoside O-acetyltransferase activity
Processes
lactose biosynthetic process
Components
cytoplasm
General Function
Galactoside o-acetyltransferase activity
Specific Function
May assist cellular detoxification by acetylating non-metabolizable pyranosides, thereby preventing their reentry into the cell.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016417|Galactoside O-acetyltransferase (lacA)
TTGAACATGCCAATGACCGAAAGAATAAGAGCAGGCAAGCTATTTACCGATATGTGCGAA
GGCTTACCGGAAAAAAGACTTCGTGGGAAAACGTTAATGTATGAGTTTAATCACTCGCAT
CCATCAGAAGTTGAAAAAAGAGAAAGCCTGATTAAAGAAATGTTTGCCACGGTAGGGGAA
AACGCCTGGGTAGAACCGCCTGTCTATTTCTCTTACGGTTCCAACATCCATATAGGCCGC
AATTTTTATGCAAATTTCAATTTAACCATTGTCGATGACTACACGGTAACAATCGGTGAT
AACGTACTGATTGCACCCAACGTTACTCTTTCCGTTACGGGACACCCTGTACACCATGAA
TTGAGAAAAAACGGCGAGATGTACTCTTTTCCGATAACGATTGGCAATAACGTCTGGATC
GGAAGTCATGTGGTTATTAATCCAGGCGTCACCATCGGGGATAATTCTGTTATTGGCGCG
GGTAGTATCGTCACAAAAGACATTCCACCAAACGTCGTGGCGGCTGGCGTTCCTTGTCGG
GTTATTCGCGAAATAAACGACCGGGATAAGCACTATTATTTCAAAGATTATAAAGTTGAA
TCGTCAGTTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP07464
UniProtKB Entry NameTHGA_ECOLI
GenBank Protein ID551814
GenBank Gene IDJ01636
General References
  1. Fowler AV, Hediger MA, Musso RE, Zabin I: The amino acid sequence of thiogalactoside transacetylase of Escherichia coli. Biochimie. 1985 Jan;67(1):101-8. [Article]
  2. Hediger MA, Johnson DF, Nierlich DP, Zabin I: DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region. Proc Natl Acad Sci U S A. 1985 Oct;82(19):6414-8. [Article]
  3. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  4. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  5. Buchel DE, Gronenborn B, Muller-Hill B: Sequence of the lactose permease gene. Nature. 1980 Feb 7;283(5747):541-5. [Article]
  6. Wang XG, Olsen LR, Roderick SL: Structure of the lac operon galactoside acetyltransferase. Structure. 2002 Apr;10(4):581-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01862Isopropyl beta-D-thiogalactopyranosideexperimentalunknownDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB026324-nitrophenyl-beta-D-galactosideexperimentalunknownDetails