Multidrug resistance protein 1

Details

Name
Multidrug resistance protein 1
Synonyms
  • 3.6.3.44
  • ATP-binding cassette sub-family B member 1
  • MDR1
  • P-glycoprotein 1
  • PGY1
Gene Name
ABCB1
Organism
Human
Amino acid sequence
>lcl|BSEQ0037114|Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ
Number of residues
1280
Molecular Weight
141477.255
Theoretical pI
9.44
GO Classification
Functions
transporter activity / ATP binding / xenobiotic-transporting ATPase activity / ATPase activity, coupled to transmembrane movement of substances
Processes
transmembrane transport / transport / drug transmembrane transport / G2/M transition of mitotic cell cycle / response to drug / stem cell proliferation / small molecule metabolic process
Components
membrane / plasma membrane / cell surface / integral component of membrane / extracellular exosome
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Pfam Domain Function
Transmembrane Regions
45-67 117-137 187-208 216-236 293-316 331-352 712-732 757-777 833-853 855-874 935-957 974-995
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016291|Multidrug resistance protein 1 (ABCB1)
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCC
AAGATTAATGAAGGAATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGTCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTTCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATTGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA
Chromosome Location
7
Locus
7q21.1
External Identifiers
ResourceLink
UniProtKB IDP08183
UniProtKB Entry NameMDR1_HUMAN
GenBank Protein ID307180
GenBank Gene IDM14758
GenAtlas IDABCB1
HGNC IDHGNC:40
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00171ATPnutraceuticalunknownDetails
DB00778Roxithromycinapproved, withdrawnunknownDetails
DB04881ElacridarinvestigationalunknownDetails
DB04905TesmilifeneinvestigationalyesinducerDetails
DB05449FM-VP4investigationalunknownDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorinducerDetails
DB01232Saquinavirapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00220NelfinavirapprovedunknownsubstrateinhibitorinducerDetails
DB00224IndinavirapprovedunknownsubstrateinhibitorinducerDetails
DB00701AmprenavirapprovedunknowninhibitorinducerDetails
DB01045RifampicinapprovedunknownsubstrateinhibitorinducerDetails
DB00206ReserpineapprovedunknownsubstrateinhibitorinducerDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorinducerDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorinducerDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorinducerDetails
DB00564Carbamazepineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00656Trazodoneapproved, investigationalunknowninducerDetails
DB01149Nefazodoneapproved, withdrawnunknowninducerDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00390DigoxinapprovedunknownsubstrateinhibitorinducerDetails
DB00279Liothyronineapproved, vet_approvedunknowninducerDetails
DB00451LevothyroxineapprovedunknowninducerDetails
DB00440Trimethoprimapproved, vet_approvedunknowninhibitorinducerDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateinhibitorinducerDetails
DB02261Platelet Activating FactorexperimentalunknowninducerDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00501CimetidineapprovedunknownsubstrateinhibitorinducerDetails
DB04630AldosteroneexperimentalunknownsubstrateinducerDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00877Sirolimusapproved, investigationalunknowninhibitorinducerDetails
DB01174PhenobarbitalapprovedunknownsubstrateinducerDetails
DB00683Midazolamapproved, illicitunknownsubstrateinhibitorinducerDetails
DB00199Erythromycinapproved, vet_approvednoinhibitorDetails
DB01118Amiodaroneapproved, investigationalunknowninhibitorinducerDetails
DB01323St. John's WortnutraceuticalunknowninducerDetails
DB00541Vincristineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00570VinblastineapprovedunknownsubstrateinhibitorinducerDetails
DB02659Cholic AcidapprovedunknowninducerDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorinducerDetails
DB00428StreptozocinapprovedunknowninducerDetails
DB01204Mitoxantroneapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00997Doxorubicinapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00694DaunorubicinapprovedunknownsubstrateinhibitorinducerDetails
DB00908QuinidineapprovedunknownsubstrateinhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01388MibefradilwithdrawnunknowninhibitorDetails
DB04540CholesterolexperimentalunknowninhibitorDetails
DB00358MefloquineapprovedunknowninhibitorDetails
DB00622NicardipineapprovedunknownsubstrateinhibitorDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB00624Testosteroneapproved, investigationalunknowninhibitorDetails
DB00972AzelastineapprovedunknowninhibitorDetails
DB00863RanitidineapprovedunknownsubstrateinhibitorDetails
DB01032ProbenecidapprovedunknowninhibitorDetails
DB00773EtoposideapprovedunknownsubstrateinhibitorDetails
DB00333MethadoneapprovedunknowninhibitorDetails
DB00641SimvastatinapprovedunknowninhibitorDetails
DB00227Lovastatinapproved, investigationalunknowninhibitorDetails
DB01076AtorvastatinapprovedunknowninhibitorDetails
DB00361Vinorelbineapproved, investigationalunknowninhibitorDetails
DB01229Paclitaxelapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00457PrazosinapprovedunknownsubstrateinhibitorDetails
DB01054NitrendipineapprovedunknowninhibitorDetails
DB01400Neostigmineapproved, vet_approvedunknowninhibitorDetails
DB00643Mebendazoleapproved, vet_approvedunknowninhibitorDetails
DB00975DipyridamoleapprovedunknownsubstrateinhibitorDetails
DB00343DiltiazemapprovedunknownsubstrateinhibitorDetails
DB01394ColchicineapprovedunknownsubstrateinhibitorDetails
DB01211ClarithromycinapprovedunknownsubstrateinhibitorDetails
DB00477Chlorpromazineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00608Chloroquineapproved, vet_approvedunknowninhibitorDetails
DB00970DactinomycinapprovedunknownsubstrateinhibitorDetails
DB13179TroleandomycinapprovedunknowninhibitorDetails
DB00831TrifluoperazineapprovedunknowninhibitorDetails
DB00342TerfenadinewithdrawnunknowninhibitorDetails
DB00468QuinineapprovedunknownsubstrateinhibitorDetails
DB01167Itraconazoleapproved, investigationalunknowninhibitorDetails
DB00328Indomethacinapproved, investigationalunknownsubstrateinhibitorDetails
DB02587ColforsinexperimentalunknowninhibitorDetails
DB00623FluphenazineapprovedunknowninhibitorDetails
DB01023Felodipineapproved, investigationalunknowninhibitorDetails
DB00845Clofazimineapproved, investigationalunknowninhibitorDetails
DB01136Carvedilolapproved, investigationalunknowninhibitorDetails
DB00421SpironolactoneapprovedunknowninhibitorDetails
DB04417P-NitrophenolexperimentalunknowninhibitorDetails
DB00281Lidocaineapproved, vet_approvedunknowninhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknowninhibitorDetails
DB00514DextromethorphanapprovedunknowninhibitorDetails
DB00531Cyclophosphamideapproved, investigationalunknowninhibitorDetails
DB00537Ciprofloxacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00207AzithromycinapprovedunknowninhibitorDetails
DB00316AcetaminophenapprovedunknownsubstrateinhibitorDetails
DB00196FluconazoleapprovedunknowninhibitorDetails
DB00213PantoprazoleapprovedunknowninhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00448Lansoprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00790PerindoprilapprovedunknowninhibitorDetails
DB00264Metoprololapproved, investigationalunknownsubstrateinhibitorDetails
DB00678LosartanapprovedunknownsubstrateinhibitorDetails
DB00584Enalaprilapproved, vet_approvedunknowninhibitorDetails
DB00590DoxazosinapprovedunknowninhibitorDetails
DB01340CilazaprilapprovedunknowninhibitorDetails
DB01197CaptoprilapprovedunknowninhibitorDetails
DB00796Candesartan cilexetilapprovedunknowninhibitorDetails
DB00335AtenololapprovedunknownsubstrateinhibitorDetails
DB00518Albendazoleapproved, vet_approvedunknowninhibitorDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00696ErgotamineapprovedunknowninhibitorDetails
DB01253ErgonovineapprovedunknowninhibitorDetails
DB00320DihydroergotamineapprovedunknowninhibitorDetails
DB01200Bromocriptineapproved, investigationalunknownsubstrateinhibitorDetails
DB00836LoperamideapprovedunknownsubstrateinhibitorDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB00802Alfentanilapproved, illicitunknowninhibitorDetails
DB00401NisoldipineapprovedunknowninhibitorDetails
DB04832ZimelidinewithdrawnunknowninhibitorDetails
DB00382TacrinewithdrawnunknowninhibitorDetails
DB00669Sumatriptanapproved, investigationalunknowninhibitorDetails
DB01037Selegilineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00747ScopolamineapprovedunknowninhibitorDetails
DB01595NitrazepamapprovedunknowninhibitorDetails
DB00704Naltrexoneapproved, investigational, vet_approvedunknowninhibitorDetails
DB00371Meprobamateapproved, illicitunknowninhibitorDetails
DB00934MaprotilineapprovedunknowninhibitorDetails
DB01221Ketamineapproved, vet_approvedunknowninhibitorDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00502HaloperidolapprovedunknownsubstrateinhibitorDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00690Flurazepamapproved, illicitunknowninhibitorDetails
DB00472Fluoxetineapproved, vet_approvedunknowninhibitorDetails
DB01142DoxepinapprovedunknowninhibitorDetails
DB01151DesipramineapprovedunknowninhibitorDetails
DB01242Clomipramineapproved, vet_approvedunknowninhibitorDetails
DB01239Chlorprothixeneapproved, withdrawnunknowninhibitorDetails
DB00490Buspironeapproved, investigationalunknowninhibitorDetails
DB00810BiperidenapprovedunknowninhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateinhibitorDetails
DB00915AmantadineapprovedunknowninhibitorDetails
DB01100PimozideapprovedunknowninhibitorDetails
DB00295Morphineapproved, investigationalunknownsubstrateinhibitorDetails
DB00602Ivermectinapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00741Hydrocortisoneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00637Astemizoleapproved, withdrawnunknowninhibitorDetails
DB00508Triflupromazineapproved, vet_approvedunknowninhibitorDetails
DB00344ProtriptylineapprovedunknowninhibitorDetails
DB01069PromethazineapprovedunknowninhibitorDetails
DB00672ChlorpropamideapprovedunknowninhibitorDetails
DB01244Bepridilapproved, withdrawnunknowninhibitorDetails
DB00455LoratadineapprovedunknowninhibitorDetails
DB00967Desloratadineapproved, investigationalunknowninhibitorDetails
DB00285VenlafaxineapprovedunknownsubstrateinhibitorDetails
DB01104SertralineapprovedunknowninhibitorDetails
DB00234Reboxetineapproved, investigationalunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB00215CitalopramapprovedunknownsubstrateinhibitorDetails
DB01196EstramustineapprovedunknowninhibitorDetails
DB04348Taurocholic AcidexperimentalunknownsubstrateinhibitorDetails
DB00875Flupentixolapproved, withdrawnunknowninhibitorDetails
DB00351Megestrol acetateapproved, vet_approvedunknowninhibitorDetails
DB02010StaurosporineexperimentalunknowninhibitorDetails
DB01103QuinacrineapprovedunknowninhibitorDetails
DB01645GenisteininvestigationalunknowninhibitorDetails
DB04216QuercetinexperimentalunknowninhibitorDetails
DB00345Aminohippuric acidapprovedunknowninhibitorDetails
DB01137Levofloxacinapproved, investigationalunknownsubstrateinhibitorDetails
DB03467NaringeninexperimentalunknowninhibitorDetails
DB01016GlyburideapprovedunknowninhibitorDetails
DB00201CaffeineapprovedunknownsubstrateinhibitorDetails
DB00950FexofenadineapprovedunknownsubstrateinhibitorDetails
DB01138SulfinpyrazoneapprovedunknowninhibitorDetails
DB03796Palmitic AcidexperimentalunknowninhibitorDetails
DB09462Glycerinapproved, investigationalunknowninhibitorDetails
DB00726TrimipramineapprovedunknowninhibitorDetails
DB00571Propranololapproved, investigationalunknownsubstrateinhibitorDetails
DB00635Prednisoneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00276AmsacrineapprovedunknowninhibitorDetails
DB00305MitomycinapprovedunknowninhibitorDetails
DB00027Gramicidin DapprovedunknowninhibitorDetails
DB01086BenzocaineapprovedunknowninhibitorDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB00520CaspofunginapprovedunknowninhibitorDetails
DB00175PravastatinapprovedunknownsubstrateinhibitorDetails
DB00619ImatinibapprovedunknownsubstrateinhibitorDetails
DB00398Sorafenibapproved, investigationalunknownsubstrateinhibitorDetails
DB01268Sunitinibapproved, investigationalunknowninhibitorDetails
DB01162TerazosinapprovedunknowninhibitorDetails
DB00470Dronabinolapproved, illicitunknowninhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB00966Telmisartanapproved, investigationalunknowninhibitorDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB04868Nilotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00655EstroneapprovedunknownsubstrateinducerDetails
DB01259Lapatinibapproved, investigationalunknowninhibitorDetails
DB01263Posaconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00365GrepafloxacinwithdrawnunknownsubstrateinhibitorDetails
DB00829Diazepamapproved, illicit, vet_approvedunknownsubstrateDetails
DB01396DigitoxinapprovedunknownsubstrateDetails
DB01208SparfloxacinapprovedunknownsubstrateDetails
DB00959Methylprednisoloneapproved, vet_approvedunknownsubstrateDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB00334Olanzapineapproved, investigationalunknownsubstrateDetails
DB00363ClozapineapprovedunknownsubstrateDetails
DB01183Naloxoneapproved, vet_approvedunknownsubstrateDetails
DB00515CisplatinapprovedunknownsubstrateDetails
DB04690CamptothecinexperimentalunknownsubstrateDetails
DB00860Prednisoloneapproved, vet_approvedunknownsubstrateDetails
DB01193AcebutololapprovedunknownsubstrateDetails
DB01050IbuprofenapprovedunknownsubstrateDetails
DB00936Salicylic acidapproved, vet_approvedunknownsubstrateDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknownsubstrateDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00742Mannitolapproved, investigationalunknownsubstrateDetails
DB00443Betamethasoneapproved, vet_approvedunknownsubstrateDetails
DB00539Toremifeneapproved, investigationalunknownsubstrateDetails
DB00255DiethylstilbestrolapprovedunknownsubstrateDetails
DB00882Clomifeneapproved, investigationalunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB01248Docetaxelapproved, investigationalunknownsubstrateDetails
DB00563MethotrexateapprovedunknownsubstrateDetails
DB00373TimololapprovedunknownsubstrateDetails
DB01203NadololapprovedunknownsubstrateDetails
DB00523Alitretinoinapproved, investigationalunknownsubstrateDetails
DB01339VecuroniumapprovedunknownsubstrateDetails
DB04840DebrisoquinapprovedunknownsubstrateDetails
DB00441GemcitabineapprovedunknownsubstrateDetails
DB01030Topotecanapproved, investigationalunknownsubstrateDetails
DB02901DihydrotestosteroneillicitunknownsubstrateDetails
DB00751Epinastineapproved, investigationalunknownsubstrateDetails
DB00717NorethisteroneapprovedunknowninducerDetails
DB04573Estriolapproved, vet_approvedunknownsubstrateinducerDetails
DB03203SphingosineexperimentalunknownsubstrateDetails
DB00439CerivastatinwithdrawnunknownsubstrateDetails
DB00286Conjugated estrogensapprovedunknownsubstrateDetails
DB01202Levetiracetamapproved, investigationalunknownsubstrateDetails
DB00252Phenytoinapproved, vet_approvedunknownsubstrateDetails
DB00585NizatidineapprovedunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00555Lamotrigineapproved, investigationalunknownsubstrateDetails
DB01261Sitagliptinapproved, investigationalunknownsubstrateDetails
DB01072Atazanavirapproved, investigationalunknownsubstrateinhibitorDetails
DB01169Arsenic trioxideapproved, investigationalunknownsubstrateDetails
DB06772CabazitaxelapprovedunknownsubstrateinhibitorDetails
DB01583LiotrixapprovedunknowninducerDetails
DB06287TemsirolimusapprovedunknownsubstrateinhibitorDetails
DB01587KetazolamapprovedunknownsubstrateDetails
DB04877Voacamineapproved, investigationalunknownDetails
DB00977Ethinyl EstradiolapprovedunknownsubstrateDetails
DB01182PropafenoneapprovedunknowninhibitorDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB04855DronedaroneapprovedunknowninhibitorDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB06207SilodosinapprovedunknownsubstrateDetails
DB06414EtravirineapprovedunknowninhibitorDetails
DB06228RivaroxabanapprovedunknownsubstrateDetails
DB06695Dabigatran etexilateapprovedunknownsubstrateDetails
DB00973EzetimibeapprovedunknownsubstrateDetails
DB06702FesoterodineapprovedunknownsubstrateDetails
DB06212TolvaptanapprovednosubstrateinhibitorDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB06589PazopanibapprovedunknownsubstrateDetails
DB08867UlipristalapprovednosubstrateDetails
DB08870Brentuximab vedotinapprovednosubstrateDetails
DB08864RilpivirineapprovedunknowninhibitorDetails
DB08873BoceprevirwithdrawnunknowninhibitorDetails
DB05521TelaprevirwithdrawnunknownsubstrateinhibitorDetails
DB08874FidaxomicinapprovedunknownsubstrateinhibitorDetails
DB05039IndacaterolapprovedunknownsubstrateDetails
DB00349Clobazamapproved, illicitunknownsubstrateDetails
DB08882LinagliptinapprovedunknownsubstrateDetails
DB08827LomitapideapprovednoinhibitorDetails
DB08816TicagrelorapprovedunknownsubstrateinhibitorDetails
DB08865CrizotinibapprovedunknownsubstrateinhibitorDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08828VismodegibapprovedunknownsubstrateDetails
DB08889CarfilzomibapprovedunknownsubstrateDetails
DB08893MirabegronapprovedunknownsubstrateDetails
DB08896RegorafenibapprovedunknowninhibitorDetails
DB08899EnzalutamideapprovedunknowninhibitorDetails
DB08820IvacaftorapprovednoinhibitorDetails
DB06616BosutinibapprovedunknownsubstrateinhibitorDetails
DB08901PonatinibapprovedunknownsubstrateinhibitorDetails
DB08906Fluticasone furoateapprovedunknownsubstrateDetails
DB08907CanagliflozinapprovedunknownsubstrateinhibitorDetails
DB08910PomalidomideapprovedunknownsubstrateDetails
DB00480LenalidomideapprovedunknownsubstrateDetails
DB08912DabrafenibapprovedunknownsubstrateDetails
DB05773Trastuzumab emtansineapprovedunknownsubstrateDetails
DB00495ZidovudineapprovedunknownsubstrateDetails
DB00758Clopidogrelapproved, nutraceuticalunknownsubstrateDetails
DB08916AfatinibapprovedunknownsubstrateinhibitorDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB00709Lamivudineapproved, investigationalunknownsubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB08918LevomilnacipranapprovedunknownsubstrateDetails
DB06290SimeprevirapprovedunknownsubstrateinhibitorDetails
DB08934SofosbuvirapprovednosubstrateDetails
DB06292DapagliflozinapprovedunknownsubstrateDetails
DB09076UmeclidiniumapprovednosubstrateDetails
DB09075EdoxabanapprovednosubstrateDetails
DB09063CeritinibapprovednosubstrateDetails
DB09078LenvatinibapprovednosubstrateDetails
DB09079NintedanibapprovednosubstrateDetails
DB09054IdelalisibapprovednosubstrateinhibitorDetails
DB09065CobicistatapprovedyesinhibitorDetails
DB09291RolapitantapprovednoinhibitorDetails
DB09102DaclatasvirapprovedunknowninhibitorDetails
DB06636Isavuconazoniumapproved, investigationalyesinhibitorDetails
DB06603Panobinostatapproved, investigationalyessubstrateDetails
DB05239CobimetinibapprovedunknownsubstrateDetails
DB09330OsimertinibapprovednosubstrateDetails
DB11362SelexipagapprovednosubstrateDetails
DB11363AlectinibapprovednoinhibitorDetails
DB06403Ambrisentanapproved, investigationalunknownsubstrateDetails
DB09296OmbitasvirapprovednosubstrateDetails
DB11574ElbasvirapprovednosubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB09161Technetium Tc-99m sestamibiapprovednosubstrateDetails
DB11581VenetoclaxapprovednosubstrateDetails
DB09462Glycerinapproved, investigationalyesinhibitorDetails
DB05015Belinostatapproved, investigationalunknownsubstrateDetails
DB11613VelpatasvirapprovednosubstrateinhibitorDetails
DB06670OdanacatibinvestigationalnosubstrateDetails
DB09027LedipasvirapprovednotransporterDetails
DB09198LobeglitazoneapprovednoDetails
DB09031MiltefosineapprovedunknownDetails
DB09280LumacaftorapprovednoinhibitorinducerDetails
DB12026VoxilaprevirapprovednosubstrateinhibitorDetails
DB13874EnasidenibapprovedunknownsubstrateinhibitorDetails
DB05889Inotuzumab ozogamicinapprovedunknownsubstrateDetails
DB13878PibrentasvirapprovedunknownsubstrateinhibitorDetails
DB13879GlecaprevirapprovedunknownsubstrateinhibitorDetails
DB12483CopanlisibapprovedunknownsubstrateDetails
DB12001AbemaciclibapprovedunknownsubstrateinhibitorDetails
DB12364Betrixabanapproved, investigationalnotransporterDetails