Cytochrome P450 3A4

Details

Name
Cytochrome P450 3A4
Synonyms
  • 1,8-cineole 2-exo-monooxygenase
  • 1.14.13.-
  • Albendazole monooxygenase
  • Albendazole sulfoxidase
  • Cholesterol 25-hydroxylase
  • CYP3A3
  • CYPIIIA3
  • CYPIIIA4
  • Cytochrome P450 3A3
  • Cytochrome P450 HLp
  • Cytochrome P450 NF-25
  • Cytochrome P450-PCN1
  • Nifedipine oxidase
  • Quinine 3-monooxygenase
  • Taurochenodeoxycholate 6-alpha-hydroxylase
Gene Name
CYP3A4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021936|Cytochrome P450 3A4
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
Number of residues
503
Molecular Weight
57342.67
Theoretical pI
8.25
GO Classification
Functions
albendazole monooxygenase activity / aromatase activity / caffeine oxidase activity / enzyme binding / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxygen binding / quinine 3-monooxygenase activity / steroid binding / steroid hydroxylase activity / taurochenodeoxycholate 6alpha-hydroxylase activity / testosterone 6-beta-hydroxylase activity / vitamin D 24-hydroxylase activity / vitamin D3 25-hydroxylase activity
Processes
alkaloid catabolic process / androgen metabolic process / calcitriol biosynthetic process from calciol / drug catabolic process / drug metabolic process / exogenous drug catabolic process / heterocycle metabolic process / lipid metabolic process / monoterpenoid metabolic process / oxidation-reduction process / oxidative demethylation / small molecule metabolic process / steroid catabolic process / steroid metabolic process / vitamin D metabolic process / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / integral component of membrane / intracellular membrane-bounded organelle
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
Pfam Domain Function
Transmembrane Regions
2-22
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0021937|Cytochrome P450 3A4 (CYP3A4)
ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG
CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG
CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT
GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT
GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT
GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA
GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA
AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG
AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC
ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA
GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT
CTCTCAATAATCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTT
CCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTC
GAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCA
AAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATC
TTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTG
GCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAAT
AAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAAT
GAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTT
GAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTT
CACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAG
AAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAAC
TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG
AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGA
CTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGT
GGAGCCTGA
Chromosome Location
7
Locus
7q21.1
External Identifiers
ResourceLink
UniProtKB IDP08684
UniProtKB Entry NameCP3A4_HUMAN
GenBank Gene IDM18907
GenAtlas IDCYP3A4
HGNC IDHGNC:2637
General References
  1. Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5311-5. [Article]
  2. Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA. 1988 Mar;7(2):79-86. [Article]
  3. Beaune PH, Umbenhauer DR, Bork RW, Lloyd RS, Guengerich FP: Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8064-8. [Article]
  4. Spurr NK, Gough AC, Stevenson K, Wolf CR: The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter. Hum Genet. 1989 Jan;81(2):171-4. [Article]
  5. Bork RW, Muto T, Beaune PH, Srivastava PK, Lloyd RS, Guengerich FP: Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem. 1989 Jan 15;264(2):910-9. [Article]
  6. Chen Q, Wu J, Yu Y: [Establishment of transgenic cell line CHL-3A4 and its metabolic activation]. Zhonghua Yu Fang Yi Xue Za Zhi. 1998 Sep;32(5):281-4. [Article]
  7. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [Article]
  8. Hsieh KP, Lin YY, Cheng CL, Lai ML, Lin MS, Siest JP, Huang JD: Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos. 2001 Mar;29(3):268-73. [Article]
  9. Komori M, Hashizume T, Ohi H, Miura T, Kitada M, Nagashima K, Kamataki T: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization. J Biochem. 1988 Dec;104(6):912-6. [Article]
  10. Watkins PB, Wrighton SA, Maurel P, Schuetz EG, Mendez-Picon G, Parker GA, Guzelian PS: Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6310-4. [Article]
  11. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem. 1989 Jun 25;264(18):10388-95. [Article]
  12. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther. 1994 Jul;270(1):414-23. [Article]
  13. Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM, Watkins PB: CYP3A gene expression in human gut epithelium. Pharmacogenetics. 1994 Oct;4(5):247-59. [Article]
  14. Zhang H, Coville PF, Walker RJ, Miners JO, Birkett DJ, Wanwimolruk S: Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. Br J Clin Pharmacol. 1997 Mar;43(3):245-52. [Article]
  15. Zhao XJ, Kawashiro T, Ishizaki T: Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways. Drug Metab Dispos. 1998 Feb;26(2):188-91. [Article]
  16. Miyazawa M, Shindo M, Shimada T: Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metab Dispos. 2001 Feb;29(2):200-5. [Article]
  17. Finta C, Zaphiropoulos PG: Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem. 2002 Feb 22;277(8):5882-90. Epub 2001 Nov 28. [Article]
  18. Dauchy S, Dutheil F, Weaver RJ, Chassoux F, Daumas-Duport C, Couraud PO, Scherrmann JM, De Waziers I, Decleves X: ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. J Neurochem. 2008 Dec;107(6):1518-28. doi: 10.1111/j.1471-4159.2008.05720.x. [Article]
  19. Agarwal V, Kommaddi RP, Valli K, Ryder D, Hyde TM, Kleinman JE, Strobel HW, Ravindranath V: Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite. PLoS One. 2008 Jun 11;3(6):e2337. doi: 10.1371/journal.pone.0002337. [Article]
  20. Pabarcus MK, Hoe N, Sadeghi S, Patterson C, Wiertz E, Correia MA: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch Biochem Biophys. 2009 Mar 1;483(1):66-74. doi: 10.1016/j.abb.2008.12.001. Epub 2008 Dec 10. [Article]
  21. Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottee L, Bieche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Decleves X, Duyckaerts C, Loriot MA: Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos. 2009 Jul;37(7):1528-38. doi: 10.1124/dmd.109.027011. Epub 2009 Apr 9. [Article]
  22. Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y, Teramoto T, Matsuzaki Y: Cholesterol 25-hydroxylation activity of CYP3A. J Lipid Res. 2011 Aug;52(8):1509-16. doi: 10.1194/jlr.M014084. Epub 2011 May 16. [Article]
  23. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  24. Yano JK, Wester MR, Schoch GA, Griffin KJ, Stout CD, Johnson EF: The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution. J Biol Chem. 2004 Sep 10;279(37):38091-4. Epub 2004 Jul 16. [Article]
  25. Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H: Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15. [Article]
  26. Sata F, Sapone A, Elizondo G, Stocker P, Miller VP, Zheng W, Raunio H, Crespi CL, Gonzalez FJ: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clin Pharmacol Ther. 2000 Jan;67(1):48-56. [Article]
  27. Dai D, Tang J, Rose R, Hodgson E, Bienstock RJ, Mohrenweiser HW, Goldstein JA: Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther. 2001 Dec;299(3):825-31. [Article]
  28. Eiselt R, Domanski TL, Zibat A, Mueller R, Presecan-Siedel E, Hustert E, Zanger UM, Brockmoller J, Klenk HP, Meyer UA, Khan KK, He YA, Halpert JR, Wojnowski L: Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics. 2001 Jul;11(5):447-58. [Article]
  29. Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, Zhang J, Schuetz EG: Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics. 2002 Mar;12(2):121-32. [Article]
  30. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05478Pradefovir mesylateinvestigationalunknownDetails
DB00180Flunisolideapproved, investigationalunknownsubstrateinducerDetails
DB00185CevimelineapprovedunknownsubstrateDetails
DB00188Bortezomibapproved, investigationalnosubstrateDetails
DB00196Fluconazoleapproved, investigationalunknowninhibitorDetails
DB00204Dofetilideapproved, investigationalunknownsubstrateDetails
DB00213PantoprazoleapprovedunknownsubstrateDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB00220NelfinavirapprovednosubstrateinhibitorDetails
DB00224IndinavirapprovedunknownsubstrateinhibitorDetails
DB00227Lovastatinapproved, investigationalunknownsubstrateinhibitorDetails
DB00234Reboxetineapproved, experimentalunknownsubstrateinhibitorDetails
DB00238NevirapineapprovedunknownsubstrateinducerDetails
DB00243Ranolazineapproved, investigationalnosubstrateinhibitorDetails
DB00246ZiprasidoneapprovedunknownsubstrateDetails
DB00270Isradipineapproved, investigationalunknownsubstrateinhibitorDetails
DB00280DisopyramideapprovedunknownsubstrateDetails
DB00286Conjugated estrogensapprovednosubstrateDetails
DB00294Etonogestrelapproved, investigationalnosubstrateDetails
DB00297Bupivacaineapproved, investigationalunknownsubstrateDetails
DB00307Bexaroteneapproved, investigationalunknownsubstrateinducerDetails
DB00309Vindesineapproved, investigationalunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00320Dihydroergotamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00324Fluorometholoneapproved, investigationalunknownsubstrateinducerDetails
DB00342Terfenadineapproved, withdrawnunknownsubstrateinhibitorDetails
DB00343Diltiazemapproved, investigationalunknownsubstrateinhibitorDetails
DB00346Alfuzosinapproved, investigationalunknownsubstrateDetails
DB00361Vinorelbineapproved, investigationalnosubstrateDetails
DB00365Grepafloxacinapproved, investigational, withdrawnunknownsubstrateDetails
DB00370MirtazapineapprovedunknownsubstrateinhibitorDetails
DB00381AmlodipineapprovednosubstrateDetails
DB00393Nimodipineapproved, investigationalunknownsubstrateDetails
DB00398Sorafenibapproved, investigationalunknownsubstrateinhibitorDetails
DB00401NisoldipineapprovedunknownsubstrateDetails
DB00402Eszopicloneapproved, investigationalunknownsubstrateDetails
DB00404Alprazolamapproved, illicit, investigationalunknownsubstrateDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB00443Betamethasoneapproved, vet_approvedunknownsubstrateinducerDetails
DB00455Loratadineapproved, investigationalnosubstrateinhibitorDetails
DB00468QuinineapprovedunknownsubstrateinhibitorinducerDetails
DB00470Dronabinolapproved, illicitnosubstrateinhibitorDetails
DB00471MontelukastapprovedunknownsubstrateDetails
DB00490Buspironeapproved, investigationalunknownsubstrateDetails
DB00496Darifenacinapproved, investigationalunknownsubstrateDetails
DB00518Albendazoleapproved, vet_approvedunknownsubstrateDetails
DB00528Lercanidipineapproved, investigationalunknownsubstrateinhibitorDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00533Rofecoxibapproved, investigational, withdrawnunknownsubstrateinducerDetails
DB00539Toremifeneapproved, investigationalunknownsubstrateinhibitorDetails
DB00541Vincristineapproved, investigationalunknownsubstrateDetails
DB00559Bosentanapproved, investigationalunknownsubstrateinducerDetails
DB00570VinblastineapprovedunknownsubstrateinhibitorinducerDetails
DB00582VoriconazoleapprovedunknownsubstrateinhibitorDetails
DB00588Fluticasone propionateapprovedunknownsubstrateinhibitorDetails
DB00593EthosuximideapprovedunknownsubstrateDetails
DB00603Medroxyprogesterone acetateapproved, investigationalunknownsubstrateinducerDetails
DB00604Cisaprideapproved, investigational, withdrawnunknownsubstrateDetails
DB00615Rifabutinapproved, investigationalunknownsubstrateinducerDetails
DB00619ImatinibapprovednosubstrateinhibitorDetails
DB00622Nicardipineapproved, investigationalunknownsubstrateinhibitorDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateinducerDetails
DB00625Efavirenzapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00635Prednisoneapproved, vet_approvedunknownsubstrateinducerDetails
DB00636Clofibrateapproved, investigationalunknownsubstrateinducerDetails
DB00637Astemizoleapproved, withdrawnunknownsubstrateinhibitorDetails
DB00641SimvastatinapprovedunknownsubstrateDetails
DB00673Aprepitantapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00674GalantamineapprovednosubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorinducerDetails
DB00678LosartanapprovedunknownsubstrateinhibitorDetails
DB00683Midazolamapproved, illicitunknownsubstrateinhibitorDetails
DB00696ErgotamineapprovedunknownsubstrateinhibitorDetails
DB00700EplerenoneapprovedunknownsubstrateDetails
DB00701Amprenavirapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00705DelavirdineapprovedunknownsubstrateinhibitorDetails
DB00731Nateglinideapproved, investigationalunknownsubstrateDetails
DB00736Esomeprazoleapproved, investigationalunknownsubstrateDetails
DB00741Hydrocortisoneapproved, vet_approvedunknownsubstrateinducerDetails
DB00744Zileutonapproved, investigational, withdrawnunknownsubstrateDetails
DB00745Modafinilapproved, investigationalunknownsubstrateinducerDetails
DB00757Dolasetronapproved, investigationalunknownsubstrateDetails
DB00758ClopidogrelapprovednosubstrateDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateinhibitorDetails
DB00769HydrocortamateapprovedunknowninducerDetails
DB00773EtoposideapprovedunknownsubstrateinhibitorinducerDetails
DB00778Roxithromycinapproved, investigational, withdrawnnosubstrateinhibitorDetails
DB00802Alfentanilapproved, illicitunknownsubstrateDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB00820Tadalafilapproved, investigationalnosubstrateDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00834Mifepristoneapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00836LoperamideapprovedunknownsubstrateinhibitorDetails
DB00843DonepezilapprovedunknownsubstrateDetails
DB00860Prednisoloneapproved, vet_approvedunknownsubstrateinducerDetails
DB00862VardenafilapprovedunknownsubstrateinhibitorDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateDetails
DB00872Conivaptanapproved, investigationalunknownsubstrateinhibitorDetails
DB00877Sirolimusapproved, investigationalnosubstrateDetails
DB00889Granisetronapproved, investigationalunknownsubstrateDetails
DB00897Triazolamapproved, investigationalunknownsubstrateDetails
DB00904Ondansetronapproved, withdrawnunknownsubstrateDetails
DB00906Tiagabineapproved, investigationalunknownsubstrateDetails
DB00907Cocaineapproved, illicitunknownsubstrateDetails
DB00909Zonisamideapproved, investigationalunknownsubstrateDetails
DB00910Paricalcitolapproved, investigationalunknownsubstrateDetails
DB00911Tinidazoleapproved, investigationalunknownsubstrateDetails
DB00918Almotriptanapproved, investigationalunknownsubstrateDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00932Tipranavirapproved, investigationalunknownsubstrateinhibitorDetails
DB00938SalmeterolapprovedunknownsubstrateDetails
DB00956Hydrocodoneapproved, illicit, investigationalunknownsubstrateDetails
DB00959Methylprednisoloneapproved, vet_approvedunknownsubstrateinducerDetails
DB00962Zaleplonapproved, illicit, investigationalunknownsubstrateDetails
DB00976TelithromycinapprovedunknownsubstrateinhibitorDetails
DB00977EthinylestradiolapprovedunknownsubstrateDetails
DB00990Exemestaneapproved, investigationalunknownsubstrateDetails
DB00997Doxorubicinapproved, investigationalnosubstrateinhibitorDetails
DB01002Levobupivacaineapproved, investigationalunknownsubstrateDetails
DB01006Letrozoleapproved, investigationalunknownsubstrateDetails
DB01008Busulfanapproved, investigationalunknownsubstrateDetails
DB01012CinacalcetapprovedunknownsubstrateDetails
DB01023Felodipineapproved, investigationalunknownsubstrateDetails
DB01026Ketoconazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01045RifampicinapprovedunknowninducerDetails
DB01054Nitrendipineapproved, investigationalunknownsubstrateDetails
DB01062Oxybutyninapproved, investigationalunknownsubstrateinhibitorDetails
DB01068Clonazepamapproved, illicitunknownsubstrateDetails
DB01072Atazanavirapproved, investigationalnosubstrateinhibitorDetails
DB01076AtorvastatinapprovednosubstrateDetails
DB01100PimozideapprovedunknownsubstrateDetails
DB01105Sibutramineapproved, illicit, investigational, withdrawnunknownsubstrateDetails
DB01114ChlorpheniramineapprovedunknownsubstrateDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorinducerDetails
DB01129Rabeprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01132Pioglitazoneapproved, investigationalunknownsubstrateinducerDetails
DB01149Nefazodoneapproved, withdrawnunknownsubstrateinhibitorDetails
DB01166Cilostazolapproved, investigationalunknownsubstrateDetails
DB01167Itraconazoleapproved, investigationalnosubstrateinhibitorDetails
DB01175EscitalopramapprovednosubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB01190Clindamycinapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01200Bromocriptineapproved, investigational, withdrawnnosubstrateinhibitorDetails
DB01206Lomustineapproved, investigationalunknowninhibitorDetails
DB01211ClarithromycinapprovedunknownsubstrateinhibitorDetails
DB01215Estazolamapproved, illicitunknownsubstrateDetails
DB01216FinasterideapprovedunknownsubstrateDetails
DB01218HalofantrineapprovedunknownsubstrateDetails
DB01222BudesonideapprovednosubstrateinducerDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB01227Levacetylmethadolapproved, investigational, withdrawnunknownsubstrateDetails
DB01229Paclitaxelapproved, vet_approvedunknownsubstrateinducerDetails
DB01232Saquinavirapproved, investigationalunknownsubstrateinhibitorDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB01238Aripiprazoleapproved, investigationalnosubstrateDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB01256RetapamulinapprovedunknownsubstrateDetails
DB01261Sitagliptinapproved, investigationalunknownsubstrateDetails
DB01259Lapatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB01264DarunavirapprovedunknownsubstrateinhibitorDetails
DB01268Sunitinibapproved, investigationalnosubstrateinhibitorDetails
DB01263Posaconazoleapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknownsubstrateinhibitorDetails
DB00197Troglitazoneapproved, investigational, withdrawnunknowninducerDetails
DB01601LopinavirapprovedunknownsubstrateinhibitorDetails
DB01411PranlukastinvestigationalnosubstrateDetails
DB01410Ciclesonideapproved, investigationalnosubstrateDetails
DB00969Alosetronapproved, withdrawnunknownsubstrateDetails
DB04835Maravirocapproved, investigationalunknownsubstrateDetails
DB01409TiotropiumapprovedunknownsubstrateDetails
DB01591SolifenacinapprovednosubstrateDetails
DB01011Metyraponeapproved, investigationalunknowninhibitorinducerDetails
DB00377Palonosetronapproved, investigationalunknownsubstrateDetails
DB04856DexloxiglumideinvestigationalunknownsubstrateDetails
DB04886Calanolide AinvestigationalunknownsubstrateDetails
DB00580Valdecoxibapproved, investigational, withdrawnunknownsubstrateDetails
DB06144Sertindoleapproved, investigational, withdrawnunknownsubstrateDetails
DB04977PlitidepsininvestigationalunknownsubstrateDetails
DB04905TesmilifeneinvestigationalunknownsubstrateinhibitorinducerDetails
DB00333MethadoneapprovedunknownsubstrateinhibitorinducerDetails
DB04934RifalazilinvestigationalunknownsubstrateDetails
DB04957AzimilideinvestigationalunknownsubstrateDetails
DB00199Erythromycinapproved, investigational, vet_approvednosubstrateinhibitorDetails
DB01628Etoricoxibapproved, investigationalunknownsubstrateinhibitorDetails
DB00564Carbamazepineapproved, investigationalunknownsubstrateinducerDetails
DB06155Rimonabantapproved, investigationalunknownsubstrateDetails
DB06267Udenafilapproved, investigationalunknownsubstrateDetails
DB06287TemsirolimusapprovedunknownsubstrateDetails
DB06442AvasimibeinvestigationalunknowninducerDetails
DB08502CapravirineinvestigationalunknownsubstrateDetails
DB06652VicrivirocinvestigationalunknownsubstrateDetails
DB06685LaquinimodinvestigationalunknownsubstrateDetails
DB01095FluvastatinapprovedunknownsubstrateinhibitorDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateDetails
DB00248CabergolineapprovedunknownsubstrateDetails
DB00589Lisurideapproved, investigationalunknownsubstrateDetails
DB01186Pergolideapproved, investigational, vet_approved, withdrawnunknowninhibitorDetails
DB05271RotigotineapprovedunknownsubstrateDetails
DB00439Cerivastatinapproved, withdrawnunknownsubstrateinhibitorinducerDetails
DB00257Clotrimazoleapproved, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateDetails
DB01159Halothaneapproved, vet_approvedunknownsubstrateDetails
DB01181IfosfamideapprovedunknownsubstrateinhibitorinducerDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00814Meloxicamapproved, vet_approvedunknownsubstrateDetails
DB00908Quinidineapproved, investigationalunknownsubstrateinhibitorDetails
DB00656Trazodoneapproved, investigationalunknownsubstrateDetails
DB00176Fluvoxamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateDetails
DB00540NortriptylineapprovedunknownsubstrateDetails
DB00215CitalopramapprovednosubstrateinhibitorDetails
DB00924CyclobenzaprineapprovedunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvednosubstrateinhibitorDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB06148Mianserinapproved, investigationalunknownsubstrateDetails
DB01435Antipyrineapproved, investigationalunknownsubstrateDetails
DB01118Amiodaroneapproved, investigationalnosubstrateinhibitorDetails
DB00250Dapsoneapproved, investigationalunknownsubstrateDetails
DB00531Cyclophosphamideapproved, investigationalunknownsubstrateinducerDetails
DB05109Trabectedinapproved, investigationalunknownsubstrateDetails
DB00946Phenprocoumonapproved, investigationalunknownsubstrateDetails
DB00682WarfarinapprovedunknownsubstrateinducerDetails
DB00285VenlafaxineapprovedunknownsubstrateDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB00972AzelastineapprovedunknownsubstrateinhibitorDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateinducerDetails
DB00201CaffeineapprovedunknownsubstrateDetails
DB00318Codeineapproved, illicitunknownsubstrateDetails
DB00514DextromethorphanapprovedunknownsubstrateDetails
DB01248Docetaxelapproved, investigationalunknownsubstrateinhibitorDetails
DB00502HaloperidolapprovedunknownsubstrateinhibitorDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB00446Chloramphenicolapproved, vet_approved, withdrawnunknowninhibitorDetails
DB00537Ciprofloxacinapproved, investigationalunknowninhibitorDetails
DB01059NorfloxacinapprovedunknowninhibitorDetails
DB06403Ambrisentanapproved, investigationalunknownsubstrateDetails
DB06413Armodafinilapproved, investigationalunknowninducerDetails
DB00865Benzphetamineapproved, illicitunknownsubstrateDetails
DB00612BisoprololapprovedunknownsubstrateDetails
DB00136Calcitriolapproved, nutraceuticalunknownsubstrateinducerDetails
DB00608Chloroquineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00349Clobazamapproved, illicitnosubstrateinducerDetails
DB00628Clorazepic acidapproved, illicitunknownsubstrateDetails
DB01396Digitoxinapproved, investigationalunknownsubstrateDetails
DB04855DronedaroneapprovedunknownsubstrateinhibitorDetails
DB04574Estrone sulfateapprovedunknownsubstrateDetails
DB06414EtravirineapprovedunknownsubstrateinducerDetails
DB01590EverolimusapprovedunknownsubstrateDetails
DB00949FelbamateapprovedunknownsubstrateinducerDetails
DB06702FesoterodineapprovedunknownsubstrateDetails
DB00690Flurazepamapproved, illicit, investigationalunknownsubstrateDetails
DB00499Flutamideapproved, investigationalunknownsubstrateDetails
DB01018Guanfacineapproved, investigationalunknownsubstrateDetails
DB04845Ixabepiloneapproved, investigationalunknownsubstrateDetails
DB00448Lansoprazoleapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00367Levonorgestrelapproved, investigationalunknownsubstrateDetails
DB00358Mefloquineapproved, investigationalunknownsubstrateinhibitorDetails
DB04868Nilotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB06712Nilvadipineapproved, investigationalunknownsubstrateinhibitorDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownsubstrateDetails
DB06589PazopanibapprovedunknownsubstrateinhibitorDetails
DB01621Pipotiazineapproved, investigationalunknownsubstrateDetails
DB01058Praziquantelapproved, investigational, vet_approvednosubstrateDetails
DB01087PrimaquineapprovedunknownsubstrateinhibitorDetails
DB00647Dextropropoxypheneapproved, illicit, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00912Repaglinideapproved, investigationalunknownsubstrateDetails
DB06228RivaroxabanapprovedunknownsubstrateDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB06207SilodosinapprovedunknownsubstrateDetails
DB00706Tamsulosinapproved, investigationalunknownsubstrateDetails
DB00444TeniposideapprovedunknownsubstrateinhibitorDetails
DB00759Tetracyclineapproved, vet_approved, withdrawnunknownsubstrateinhibitorDetails
DB00277TheophyllineapprovedunknownsubstrateDetails
DB01036Tolterodineapproved, investigationalunknownsubstrateDetails
DB06212TolvaptanapprovedunknownsubstrateDetails
DB00193Tramadolapproved, investigationalunknownsubstrateDetails
DB00440Trimethoprimapproved, vet_approvedunknownsubstrateDetails
DB01198ZopicloneapprovedunknownsubstrateDetails
DB00357Aminoglutethimideapproved, investigationalunknowninducerDetails
DB01320Fosphenytoinapproved, investigationalunknownsubstrateinducerDetails
DB00607Nafcillinapproved, investigationalunknowninducerDetails
DB00776OxcarbazepineapprovedunknowninhibitorinducerDetails
DB00312Pentobarbitalapproved, investigational, vet_approvedunknowninducerDetails
DB01174Phenobarbitalapproved, investigationalunknowninducerDetails
DB00252Phenytoinapproved, vet_approvednosubstrateinducerDetails
DB00794Primidoneapproved, vet_approvedunknowninducerDetails
DB01201Rifapentineapproved, investigationalunknownsubstrateinducerDetails
DB01394ColchicineapprovedunknownsubstrateinhibitorDetails
DB01253ErgometrineapprovedunknownsubstrateDetails
DB01221Ketamineapproved, vet_approvedunknownsubstrateinducerDetails
DB00353MethylergometrineapprovedunknownsubstrateinhibitorDetails
DB06335SaxagliptinapprovedunknownsubstrateDetails
DB00708Sufentanilapproved, investigationalunknownsubstrateDetails
DB01128BicalutamideapprovedunknownsubstrateinhibitorDetails
DB01151Desipramineapproved, investigationalunknowninhibitorDetails
DB00916MetronidazoleapprovedunknowninhibitorDetails
DB06268Sitaxentanapproved, investigational, withdrawnunknowninhibitorDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00363ClozapineapprovednosubstrateinhibitorinducerDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB00549Zafirlukastapproved, investigationalunknownsubstrateinhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateDetails
DB01016GlyburideapprovedunknownsubstrateinhibitorDetails
DB01138SulfinpyrazoneapprovedunknownsubstrateinducerDetails
DB06739SeratrodastexperimentalunknownsubstrateinducerDetails
DB06738KetobemidoneinvestigationalunknownsubstrateDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00655EstroneapprovednosubstrateDetails
DB00458ImipramineapprovedunknownsubstrateDetails
DB00546AdinazolamexperimentalunknownsubstrateDetails
DB00231Temazepamapproved, investigationalunknownsubstrateDetails
DB03701VanoxerineinvestigationalunknownsubstrateDetails
DB00169Cholecalciferolapproved, nutraceuticalunknownsubstrateDetails
DB01192Oxymorphoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB01173OrphenadrineapprovedunknownsubstrateinhibitorDetails
DB06772CabazitaxelapprovedunknownsubstrateDetails
DB02709ResveratrolinvestigationalnoinhibitorDetails
DB06700Desvenlafaxineapproved, investigationalnosubstrateinhibitorDetails
DB06697ArtemetherapprovedunknownsubstrateinducerDetails
DB06708LumefantrineapprovedunknownsubstrateDetails
DB00819Acetazolamideapproved, vet_approvedunknowninhibitorDetails
DB06742Ambroxolapproved, investigationalunknownsubstrateDetails
DB01223AminophyllineapprovedunknownsubstrateDetails
DB00278Argatrobanapproved, investigationalunknownsubstrateDetails
DB01169Arsenic trioxideapproved, investigationalunknowninhibitorDetails
DB00207AzithromycinapprovedunknownsubstrateinhibitorDetails
DB01393Bezafibrateapproved, investigationalunknownsubstrateDetails
DB04794Bifonazoleapproved, investigationalunknowninhibitorDetails
DB01194BrinzolamideapprovednosubstrateDetails
DB00520CaspofunginapprovedunknowninhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknowninducerDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateinhibitorDetails
DB00845Clofazimineapproved, investigationalunknowninhibitorDetails
DB06470ClomethiazoleinvestigationalunknownsubstrateDetails
DB01559Clotiazepamapproved, illicitunknownsubstrateDetails
DB00987Cytarabineapproved, investigationalunknownsubstrateDetails
DB01406DanazolapprovedunknowninhibitorDetails
DB00694DaunorubicinapprovedunknownsubstrateinhibitorDetails
DB01093Dimethyl sulfoxideapproved, vet_approvedunknowninhibitorDetails
DB00822DisulfiramapprovedunknownsubstrateDetails
DB00254Doxycyclineapproved, investigational, vet_approvedunknowninhibitorDetails
DB01127EconazoleapprovednoinhibitorDetails
DB00751Epinastineapproved, investigationalunknownsubstrateDetails
DB00668Epinephrineapproved, vet_approvedunknowninhibitorDetails
DB01196Estramustineapproved, investigationalunknownsubstrateDetails
DB00898EthanolapprovedunknownsubstrateinhibitorinducerDetails
DB01466Ethylmorphineexperimental, illicitunknownsubstrateDetails
DB00301Flucloxacillinapproved, investigationalunknownsubstrateinducerDetails
DB01544Flunitrazepamapproved, illicitunknownsubstrateDetails
DB00947Fulvestrantapproved, investigationalunknownsubstrateDetails
DB01275HydralazineapprovednoinhibitorDetails
DB00724Imiquimodapproved, investigationalunknownsubstrateDetails
DB01029Irbesartanapproved, investigationalnoinhibitorDetails
DB00602Ivermectinapproved, investigational, vet_approvednosubstrateDetails
DB01103QuinacrineinvestigationalunknownsubstrateDetails
DB01071MequitazineexperimentalunknowninhibitorDetails
DB04817Metamizoleapproved, investigational, withdrawnunknowninducerDetails
DB04833Methaqualoneillicit, withdrawnunknownsubstrateDetails
DB01028Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownsubstrateDetails
DB06710MethyltestosteroneapprovedunknownsubstrateDetails
DB00379Mexiletineapproved, investigationalunknownsubstrateDetails
DB01204Mitoxantroneapproved, investigationalunknowninhibitorDetails
DB00295Morphineapproved, investigationalnosubstrateDetails
DB01183Naloxoneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB02701Nicotinamideapproved, investigationalunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateDetails
DB01595NitrazepamapprovedunknownsubstrateDetails
DB00768OlopatadineapprovednosubstrateDetails
DB00316AcetaminophenapprovedunknownsubstrateinducerDetails
DB01074Perhexilineapproved, investigationalunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateDetails
DB00454MeperidineapprovedunknownsubstrateinducerDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB00780PhenelzineapprovedunknowninhibitorDetails
DB00812Phenylbutazoneapproved, vet_approvedunknowninducerDetails
DB01085Pilocarpineapproved, investigationalunknowninhibitorDetails
DB01588Prazepamapproved, illicitunknownsubstrateDetails
DB01032Probenecidapproved, investigationalunknowninducerDetails
DB01182PropafenoneapprovedunknownsubstrateDetails
DB01589Quazepamapproved, illicitnosubstrateDetails
DB00481Raloxifeneapproved, investigationalunknowninhibitorDetails
DB00863Ranitidineapproved, withdrawnunknowninhibitorDetails
DB01220Rifaximinapproved, investigationalunknownsubstrateinducerDetails
DB00296RopivacaineapprovedunknownsubstrateDetails
DB01698Rutinapproved, experimental, investigationalunknowninducerDetails
DB01001Salbutamolapproved, vet_approvedunknowninhibitorDetails
DB01236Sevofluraneapproved, vet_approvedunknownsubstrateDetails
DB00359Sulfadiazineapproved, investigational, vet_approvedunknownsubstrateDetails
DB01015SulfamethoxazoleapprovedunknownsubstrateDetails
DB01349TasosartanexperimentalunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB04572Thiotepaapproved, investigationalunknownsubstrateDetails
DB01007TioconazoleapprovedunknowninhibitorDetails
DB00273TopiramateapprovedunknowninducerDetails
DB00347TrimethadioneapprovedunknownsubstrateDetails
DB13179TroleandomycinapprovedunknownsubstrateinhibitorDetails
DB00313Valproic acidapproved, investigationalunknowninhibitorDetails
DB01392Yohimbineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00495ZidovudineapprovedunknownsubstrateDetails
DB04828ZomepiracwithdrawnunknownsubstrateDetails
DB01380Cortisone acetateapproved, investigationalunknownsubstrateinducerDetails
DB01384ParamethasoneexperimentalunknownsubstrateinhibitorinducerDetails
DB01587KetazolamapprovedunknownsubstrateinhibitorDetails
DB08811TofisopamexperimentalunknowninhibitorDetails
DB00617ParamethadioneapprovedunknownsubstrateDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownsubstrateDetails
DB00980Ramelteonapproved, investigationalunknownsubstrateDetails
DB04946IloperidoneapprovedunknownsubstrateDetails
DB01418Acenocoumarolapproved, investigationalunknownsubstrateDetails
DB06684VilazodoneapprovedunknownsubstrateDetails
DB00255Diethylstilbestrolapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB00973EzetimibeapprovedunknowninhibitorDetails
DB00400Griseofulvinapproved, investigational, vet_approvedunknowninducerDetails
DB00808IndapamideapprovedunknownsubstrateDetails
DB05521Telaprevirapproved, withdrawnunknownsubstrateinhibitorDetails
DB08820IvacaftorapprovednosubstrateinhibitorDetails
DB06634CasopitantinvestigationalunknownDetails
DB04975BanoxantroneinvestigationalunknownsubstrateDetails
DB05039IndacaterolapprovedunknownsubstrateDetails
DB08816TicagrelorapprovedunknownsubstrateinhibitorDetails
DB06774CapsaicinapprovedunknowninhibitorDetails
DB06174Noscapineapproved, investigationalunknowninhibitorDetails
DB01333CefradineapprovedunknowninducerDetails
DB06777Chenodeoxycholic acidapprovedunknownsubstrateDetails
DB00856Chlorphenesinapproved, experimentalunknowninducerDetails
DB04920Clevidipineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB01764DalfopristinapprovedunknowninhibitorDetails
DB01609Deferasiroxapproved, investigationalunknowninducerDetails
DB00485Dicloxacillinapproved, investigational, vet_approvedunknowninducerDetails
DB06370IndisulaminvestigationalunknowninhibitorDetails
DB01083Orlistatapproved, investigationalunknowninducerDetails
DB00239OxiconazoleapprovedunknowninducerDetails
DB00082PegvisomantapprovedunknowninducerDetails
DB06762PinacidilapprovedunknownsubstrateDetails
DB01369QuinupristinapprovedunknowninhibitorDetails
DB00337Pimecrolimusapproved, investigationalunknownsubstrateDetails
DB00041AldesleukinapprovedunknowninhibitorDetails
DB06605ApixabanapprovednosubstrateDetails
DB08827Lomitapideapproved, investigationalnosubstrateDetails
DB08828Vismodegibapproved, investigationalnosubstrateDetails
DB00620Triamcinoloneapproved, vet_approvedunknownsubstrateinducerDetails
DB08864RilpivirineapprovednosubstrateinhibitorinducerDetails
DB06209PrasugrelapprovednosubstrateDetails
DB06216AsenapineapprovedunknownsubstrateDetails
DB00435Nitric OxideapprovedunknowninhibitorDetails
DB08867UlipristalapprovednosubstrateDetails
DB08815Lurasidoneapproved, investigationalunknownsubstrateDetails
DB08870Brentuximab vedotinapproved, investigationalnosubstrateinhibitorDetails
DB04871Lorcaserinapproved, withdrawnnosubstrateDetails
DB05294VandetanibapprovedunknownsubstrateDetails
DB08873Boceprevirapproved, withdrawnunknownsubstrateinhibitorDetails
DB08875Cabozantinibapproved, investigationalnosubstrateDetails
DB08877RuxolitinibapprovedunknownsubstrateDetails
DB05812AbirateroneapprovedunknownsubstrateinhibitorDetails
DB08881VemurafenibapprovedunknownsubstrateinducerDetails
DB08882LinagliptinapprovedunknownsubstrateinhibitorDetails
DB08883PerampanelapprovednosubstrateinducerDetails
DB08865Crizotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08893MirabegronapprovednosubstrateDetails
DB06237AvanafilapprovedunknownsubstrateDetails
DB08896RegorafenibapprovedunknownsubstrateinhibitorDetails
DB08899EnzalutamideapprovednosubstrateinducerDetails
DB08895Tofacitinibapproved, investigationalnosubstrateDetails
DB06616BosutinibapprovednosubstrateinhibitorDetails
DB08901Ponatinibapproved, investigationalunknownsubstrateDetails
DB08903BedaquilineapprovednosubstrateDetails
DB06201RufinamideapprovedunknowninducerDetails
DB08906Fluticasone furoateapprovednosubstrateinhibitorinducerDetails
DB08907CanagliflozinapprovedunknownsubstrateDetails
DB06203AlogliptinapprovedunknownsubstrateDetails
DB04938Ospemifeneapproved, investigationalunknownsubstrateDetails
DB08910PomalidomideapprovedunknownsubstrateDetails
DB08911TrametinibapprovedunknownsubstrateinducerDetails
DB08912Dabrafenibapproved, investigationalnosubstrateinhibitorinducerDetails
DB05773Trastuzumab emtansineapproved, investigationalunknownsubstrateDetails
DB08833Taurochenodeoxycholic acidexperimentalunknownsubstrateDetails
DB01142Doxepinapproved, investigationalnosubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB08918Levomilnacipranapproved, investigationalunknownsubstrateDetails
DB08932MacitentanapprovednosubstrateDetails
DB08933LuliconazoleapprovednoinhibitorDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB09039Eliglustatapproved, investigationalnosubstrateDetails
DB05676Apremilastapproved, investigationalnosubstrateDetails
DB09049NaloxegolapprovedunknownsubstrateDetails
DB09053IbrutinibapprovedunknownsubstrateDetails
DB00951Isoniazidapproved, investigationalunknownDetails
DB09074OlaparibapprovedunknownsubstrateinhibitorDetails
DB09078Lenvatinibapproved, investigationalnosubstrateinhibitorinducerDetails
DB09073Palbociclibapproved, investigationalnosubstrateinhibitorDetails
DB09054IdelalisibapprovednosubstrateinhibitorinducerDetails
DB09068Vortioxetineapproved, investigationalnosubstrateDetails
DB09082VilanterolapprovednosubstrateDetails
DB09083IvabradineapprovednosubstrateDetails
DB09026Aliskirenapproved, investigationalnosubstrateDetails
DB09101ElvitegravirapprovednosubstrateinhibitorDetails
DB06016Cariprazineapproved, investigationalnosubstrateinhibitorinducerDetails
DB08439ParecoxibapprovedunknownsubstrateDetails
DB09128Brexpiprazoleapproved, investigationalnosubstrateDetails
DB09291Rolapitantapproved, investigationalnosubstrateDetails
DB04908Flibanserinapproved, investigationalnosubstrateDetails
DB09102Daclatasvirapproved, investigationalunknownsubstrateDetails
DB09143Sonidegibapproved, investigationalunknownsubstrateDetails
DB06636Isavuconazoniumapproved, investigationalnosubstrateinhibitorinducerDetails
DB06603Panobinostatapproved, investigationalunknownsubstrateDetails
DB05239Cobimetinibapproved, investigationalnosubstrateinhibitorDetails
DB09570Ixazomibapproved, investigationalunknownsubstrateDetails
DB09330OsimertinibapprovednosubstrateinhibitorinducerDetails
DB11362SelexipagapprovednosubstrateDetails
DB09119Eslicarbazepine acetateapprovednoinducerDetails
DB06789Hydroxyprogesterone caproateapproved, investigationalunknownsubstrateDetails
DB08931RiociguatapprovedunknownsubstrateDetails
DB09183DasabuvirapprovednosubstrateDetails
DB09297Paritaprevirapproved, investigationalnosubstrateDetails
DB09317Synthetic Conjugated Estrogens, AapprovednosubstrateDetails
DB09318Synthetic Conjugated Estrogens, BapprovednosubstrateDetails
DB09389NorgestrelapprovedunknownsubstrateDetails
DB11581Venetoclaxapproved, investigationalnosubstrateinhibitorDetails
DB09280LumacaftorapprovednoinducerDetails
DB01323St. John's Wortapproved, investigational, nutraceuticalunknownsubstrateinduceractivatorDetails
DB09381Esterified estrogensapprovedunknownsubstrateDetails
DB00957Norgestimateapproved, investigationalunknownsubstrateinducerDetails
DB04911Oritavancinapproved, investigationalunknowninhibitorinducerDetails
DB06717FosaprepitantapprovedunknownsubstrateinhibitorinducerDetails
DB00648MitotaneapprovedunknowninducerDetails
DB08909Glycerol phenylbutyrateapprovedunknowninducerDetails
DB09048Netupitantapproved, investigationalnosubstrateinhibitorDetails
DB12332Rucaparibapproved, investigationalnosubstrateinhibitorDetails
DB11921Deflazacortapproved, investigationalnosubstrateinducerDetails
DB11737Icotinibexperimental, investigationalunknownsubstrateDetails
DB06654Safinamideapproved, investigationalunknownsubstrateDetails
DB12161Deutetrabenazineapproved, investigationalnosubstrateDetails
DB09555Dexchlorpheniramine maleateapprovedunknownsubstrateDetails
DB11613Velpatasvirapproved, investigationalnosubstrateDetails
DB05541Brivaracetamapproved, investigationalnosubstrateDetails
DB11915Valbenazineapproved, investigationalnosubstrateDetails
DB06670OdanacatibinvestigationalnosubstrateDetails
DB05351Dexlansoprazoleapproved, investigationalunknownsubstrateDetails
DB06290SimeprevirapprovedunknownsubstrateinhibitorDetails
DB11575GrazoprevirapprovednosubstrateinhibitorDetails
DB11943Delafloxacinapproved, investigationalunknowninducerDetails
DB01685TopiroxostatexperimentalunknowninhibitorDetails
DB08922PerospironeexperimentalunknownsubstrateDetails
DB09118StiripentolapprovedunknownsubstrateinhibitorinducerDetails
DB09166EtizolamexperimentalunknownsubstrateDetails
DB11614RupatadineapprovednosubstrateDetails
DB09262ImidafenacininvestigationalnosubstrateDetails
DB00143Glutathioneapproved, investigational, nutraceuticalunknownDetails
DB09238Manidipineapproved, investigationalunknownsubstrateinhibitorDetails
DB09123DienogestapprovedunknownsubstrateDetails
DB11828Neratinibapproved, investigationalunknownsubstrateDetails
DB12026Voxilaprevirapproved, investigationalnosubstrateDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB06412Oxymetholoneapproved, illicitunknowninhibitorDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinhibitorDetails
DB06595Midostaurinapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB11574ElbasvirapprovedunknownsubstrateDetails
DB12483Copanlisibapproved, investigationalnosubstrateDetails
DB11767Sarilumabapproved, investigationalnoinhibitorinducerDetails
DB12001Abemaciclibapproved, investigationalunknownsubstrateinhibitorDetails
DB12267Brigatinibapproved, investigationalnosubstrateDetails
DB11817Baricitinibapproved, investigationalunknownsubstrateDetails
DB13074Macimorelinapproved, investigationalunknownsubstrateDetails
DB09223BlonanserininvestigationalnosubstrateDetails
DB09236Lacidipineapproved, investigationalunknownsubstrateDetails
DB09061Cannabidiolapproved, investigationalunknownsubstrateinhibitorDetails
DB13943Testosterone cypionateapprovedunknownsubstrateinhibitorinducerDetails
DB13944Testosterone enanthateapprovedunknownsubstrateinhibitorinducerDetails
DB13946Testosterone undecanoateapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB13941Piperaquineapproved, experimental, investigationalunknownsubstrateinhibitorDetails
DB01420Testosterone propionateapproved, investigational, vet_approved, withdrawnnosubstrateDetails
DB09195LorpiprazoleapprovednosubstrateDetails
DB11799Bictegravirapproved, investigationalunknownsubstrateDetails
DB11901Apalutamideapproved, investigationalnosubstrateinducerDetails
DB09225Zotepineapproved, investigational, withdrawnnosubstrateDetails
DB09230AzelnidipineinvestigationalunknownsubstrateDetails
DB09231BenidipineexperimentalnosubstrateinhibitorDetails
DB09235EfonidipineexperimentalunknownsubstrateinhibitorDetails
DB11642Pitolisantapproved, investigationalunknownsubstrateinducerDetails
DB11633Isavuconazoleapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB09237Levamlodipineapproved, investigationalunknownsubstrateDetails
DB11712Tezacaftorapproved, investigationalnosubstrateinhibitorinducerDetails
DB11130Opiumapproved, illicitnosubstrateDetails
DB11251Tocopherolapproved, investigationalnosubstrateDetails
DB14003alpha-Tocopherol acetateapprovednosubstrateDetails
DB11586Asunaprevirapproved, investigational, withdrawnnosubstrateinducerDetails
DB13975Black cohoshexperimentalnoinhibitorDetails
DB12278Propiverineapproved, investigationalnosubstrateDetails
DB14011NabiximolsinvestigationalunknownsubstrateDetails
DB14009Medical Cannabisexperimental, investigationalunknownsubstrateinhibitorDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails
DB11635TocofersolanapprovednosubstrateDetails
DB11637Delamanidapproved, investigationalnosubstrateDetails
DB13746Bioallethrinapproved, experimentalnosubstrateDetails
DB14019FosnetupitantapprovedunknownsubstrateinhibitorDetails
DB12010Fostamatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB01049Ergoloid mesylateapprovednosubstrateDetails
DB11274Dihydro-alpha-ergocryptineapprovednosubstrateDetails
DB13293Ipecacapproved, withdrawnnosubstrateDetails
DB11198Peppermint oilapproved, investigationalunknowninhibitorDetails
DB13456MidecamycinexperimentalnosubstrateinhibitorDetails
DB12532Oxetacaineapproved, investigationalnoinhibitorDetails
DB11672Curcuminapproved, investigationalunknowninhibitorDetails
DB11779DanoprevirinvestigationalnoinhibitorDetails
DB09289TianeptineinvestigationalnosubstrateDetails
DB01357MestranolapprovednosubstrateDetails
DB04829Lysergic acid diethylamideillicit, investigational, withdrawnnosubstrateDetails
DB00247MethysergideapprovednosubstrateDetails
DB13399TergurideexperimentalnosubstrateDetails
DB14185Aripiprazole lauroxilapproved, investigationalunknownsubstrateDetails
DB11718Encorafenibapproved, investigationalnosubstrateinhibitorinducerDetails
DB14538Hydrocortisone aceponateexperimental, vet_approvedunknownsubstrateinducerDetails
DB14539Hydrocortisone acetateapproved, vet_approvedunknownsubstrateinducerDetails
DB14540Hydrocortisone butyrateapproved, vet_approvedunknownsubstrateinducerDetails
DB14541Hydrocortisone cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB14542Hydrocortisone phosphateapproved, vet_approvedunknownsubstrateDetails
DB14543Hydrocortisone probutateapproved, vet_approvedunknownsubstrateinducerDetails
DB14544Hydrocortisone valerateapproved, vet_approvedunknownsubstrateinducerDetails
DB14568Ivosidenibapproved, investigationalunknownsubstrateinducerDetails
DB126293,5-diiodothyropropionic acidinvestigationalnosubstrateDetails
DB014565-androstenedioneexperimental, illicitnosubstrateDetails
DB00240AlclometasoneapprovednosubstrateDetails
DB04630Aldosteroneexperimental, investigationalnosubstrateDetails
DB00288AmcinonideapprovednosubstrateinducerDetails
DB01536Androstenedioneexperimental, illicitnosubstrateDetails
DB00394Beclomethasone dipropionateapproved, investigationalnosubstrateinducerDetails
DB11750Clobetasolapproved, experimental, investigationalnosubstrateinducerDetails
DB01013Clobetasol propionateapprovednosubstrateinducerDetails
DB13158ClobetasoneapprovednosubstrateDetails
DB04652CorticosteroneexperimentalnosubstrateDetails
DB01285Corticotropinapproved, investigational, vet_approvednosubstrateinducerDetails
DB04839Cyproterone acetateapproved, investigationalnosubstrateinhibitorDetails
DB11636NomegestrolapprovednosubstrateDetails
DB13981Nomegestrol acetateapproved, investigationalnosubstrateDetails
DB00304DesogestrelapprovednosubstrateDetails
DB01260Desonideapproved, investigationalnosubstrateinducerDetails
DB06780Desoxycorticosterone acetateapprovednosubstrateDetails
DB01134Desoxycorticosterone pivalateexperimental, vet_approvednosubstrateDetails
DB11487Dexamethasone isonicotinatevet_approvednosubstrateinhibitorinducerDetails
DB09095Difluocortoloneapproved, investigational, withdrawnnosubstrateinducerDetails
DB06781DifluprednateapprovednosubstrateDetails
DB00378Dydrogesteroneapproved, investigational, withdrawnnosubstrateDetails
DB03515EquileninexperimentalnosubstrateDetails
DB02187EquilinexperimentalnosubstrateDetails
DB13866EtynodiolexperimentalnosubstrateDetails
DB00823Ethynodiol diacetateapprovednosubstrateDetails
DB00687Fludrocortisoneapproved, investigationalunknownsubstrateDetails
DB00663Flumethasoneapproved, vet_approvednosubstrateDetails
DB00591Fluocinolone acetonideapproved, investigational, vet_approvednosubstrateinducerDetails
DB01047Fluocinonideapproved, investigationalnosubstrateinducerDetails
DB08971Fluocortoloneapproved, withdrawnnosubstrateinducerDetails
DB08970FluprednideneexperimentalnosubstrateinducerDetails
DB09378FluprednisoloneapprovednosubstrateDetails
DB00846FlurandrenolideapprovednosubstrateDetails
DB13867Fluticasoneapproved, experimentalnosubstrateinhibitorinducerDetails
DB08905Formestaneapproved, investigational, withdrawnnoinducerDetails
DB06730GestodeneinvestigationalnosubstrateinhibitorDetails
DB11619GestrinoneapprovednosubstrateDetails
DB06786Halcinonideapproved, investigational, withdrawnnosubstrateDetails
DB05212HE3286investigationalnosubstrateDetails
DB14545Hydrocortisone succinateapprovedunknownsubstrateinducerDetails
DB14570HydroxyprogesteroneexperimentalnosubstrateDetails
DB01583LiotrixapprovednosubstrateDetails
DB14596Loteprednol etabonateapprovedunknownsubstrateDetails
DB12474Lynestrenolapproved, investigationalnosubstrateDetails
DB09124Medrogestoneapproved, withdrawnnosubstrateDetails
DB00253MedrysoneapprovednosubstrateinducerDetails
DB00351Megestrol acetateapproved, investigational, vet_approvednosubstrateDetails
DB11529Melengestrolvet_approvednosubstrateDetails
DB09383Meprednisoneapproved, investigationalnosubstrateinducerDetails
DB00764MometasoneexperimentalnosubstrateinducerDetails
DB14512Mometasone furoateapproved, investigational, vet_approvednosubstrateinducerDetails
DB06713Norelgestrominapproved, investigationalnosubstrateDetails
DB09371NorethynodrelapprovednosubstrateDetails
DB01130Prednicarbateapproved, investigationalnosubstrateDetails
DB13208PrednylideneexperimentalnosubstrateinducerDetails
DB02789Pregnenoloneapproved, experimentalnosubstrateDetails
DB13602PromegestoneexperimentalnosubstrateDetails
DB00896RimexoloneapprovednosubstrateinducerDetails
DB01117AtovaquoneapprovednosubstrateDetails
DB11753Rifamycinapproved, investigationalnoinhibitorinducerDetails
DB13528ChlormadinoneexperimentalnosubstrateDetails
DB13857DemegestoneexperimentalnosubstrateDetails
DB13685QuingestanolexperimentalnosubstrateDetails
DB14055(S)-Warfarinexperimental, investigationalnosubstrateDetails
DB13347DiphenadioneexperimentalnosubstrateDetails
DB08794Ethyl biscoumacetatewithdrawnunknownsubstrateDetails
DB01483BarbitalillicitnoinducerDetails
DB01154Thiamylalapproved, vet_approvednosubstrateinducerDetails
DB09229AranidipineexperimentalnosubstrateDetails
DB09227BarnidipineexperimentalnosubstrateinhibitorDetails
DB13488BencyclaneexperimentalnosubstrateDetails
DB01244Bepridilapproved, withdrawnnosubstrateDetails
DB08838AgmatineexperimentalnosubstrateDetails
DB11960CarboxyamidotriazoleinvestigationalnosubstrateDetails
DB13835CaroverineexperimentalnosubstrateDetails
DB09232CilnidipineinvestigationalnosubstrateDetails
DB00568Cinnarizineapproved, investigationalnosubstrateDetails
DB04838CyclandelateapprovednosubstrateDetails
DB09234DarodipineexperimentalnosubstrateDetails
DB14068DexniguldipineexperimentalnosubstrateDetails
DB14063DexverapamilexperimentalnosubstrateDetails
DB06446DotarizineinvestigationalnosubstrateDetails
DB14064EmopamilexperimentalnosubstrateDetails
DB08992EperisoneinvestigationalnosubstrateDetails
DB08980FendilinewithdrawnnosubstrateDetails
DB13961Fish oilapproved, nutraceuticalnosubstrateDetails
DB04841FlunarizineapprovednosubstrateDetails
DB04842Fluspirileneapproved, investigationalnosubstrateDetails
DB12923GallopamilinvestigationalnosubstrateDetails
DB13766Lidoflazineapproved, experimentalnosubstrateDetails
DB14065LomerizineexperimentalnosubstrateDetails
DB00825LevomentholapprovednosubstrateDetails
DB12092NaftopidilinvestigationalnosubstrateDetails
DB09239NiguldipineexperimentalnosubstrateDetails
DB09240NiludipineexperimentalnosubstrateDetails
DB04743Nimesulideapproved, investigational, withdrawnnosubstrateDetails
DB06152NylidrinapprovednosubstrateDetails
DB13500Otiloniumexperimental, investigationalnosubstrateDetails
DB13791PenfluridolexperimentalnosubstrateDetails
DB09090PinaveriumapprovednosubstrateDetails
DB04825Prenylamineapproved, withdrawnnosubstrateDetails
DB13725TerodilineexperimentalnosubstrateDetails
DB12093TetrahydropalmatineinvestigationalnosubstrateDetails
DB14066TetrandrineexperimentalnosubstrateDetails
DB09216Tolfenamic acidapproved, investigationalnosubstrateDetails
DB07615TranilastinvestigationalnosubstrateDetails
DB09089TrimebutineapprovednosubstrateDetails
DB05885SeletracetaminvestigationalnosubstrateDetails
DB12131VinpocetineinvestigationalnosubstrateDetails
DB13950WIN 55212-2experimentalnosubstrateinhibitorDetails
DB040706-Deoxyerythronolide BexperimentalnoinhibitorDetails
DB06318AVE9633investigationalnoinhibitorDetails
DB07348Brefeldin AexperimentalnoinhibitorDetails
DB11752Bryostatin 1investigationalnoinhibitorDetails
DB01152Candicidinapproved, withdrawnnoinhibitorDetails
DB11383Carbomycinvet_approvednoinhibitorDetails
DB06419CethromycininvestigationalnosubstrateinhibitorDetails
DB06342Coltuximab ravtansineinvestigationalnoinhibitorDetails
DB00954DirithromycinexperimentalnoinhibitorDetails
DB11400Doramectinvet_approvednoinhibitorDetails
DB12266EpofolateinvestigationalnoinhibitorDetails
DB01873Epothilone DinvestigationalnoinhibitorDetails
DB11405Eprinomectinvet_approvednoinhibitorDetails
DB13338FlurithromycinexperimentalnoinhibitorDetails
DB05814GPI-1485investigationalnoinhibitorDetails
DB09309KitasamycinexperimentalnoinhibitorDetails
DB05903KOS-1584investigationalnoinhibitorDetails
DB12089Lorvotuzumab mertansineinvestigationalnoinhibitorDetails
DB13287MiocamycinapprovednoinhibitorDetails
DB12489Mirvetuximab soravtansineapproved, investigationalnosubstrateinhibitorDetails
DB06587MitemcinalinvestigationalnoinhibitorDetails
DB11442Oleandomycinvet_approvednoinhibitorDetails
DB03010Patupiloneexperimental, investigationalnoinhibitorDetails
DB06233RidaforolimusinvestigationalnoinhibitorDetails
DB13409RokitamycinexperimentalnoinhibitorDetails
DB12391SagopiloneinvestigationalnoinhibitorDetails
DB11459Selamectinvet_approvednoinhibitorDetails
DB09308SolithromycininvestigationalnoinhibitorDetails
DB11470Tildipirosinvet_approvednoinhibitorDetails
DB01241GemfibrozilapprovedunknownsubstrateDetails
DB06791LanreotideapprovednoinhibitorDetails
DB00104Octreotideapproved, investigationalnoinhibitorDetails
DB06663PasireotideapprovednoinhibitorDetails
DB09099Somatostatinapproved, investigationalnoinhibitorDetails
DB04894Vapreotideexperimental, investigationalnoinhibitorDetails
DB12781BalaglitazoneinvestigationalnosubstrateDetails
DB09201CiglitazoneexperimentalnosubstrateDetails
DB09198LobeglitazoneexperimentalnosubstrateDetails
DB09199NetoglitazoneexperimentalnosubstrateDetails
DB09200Rivoglitazoneexperimental, investigationalnosubstrateDetails
DB00412Rosiglitazoneapproved, investigationalnosubstrateinducerDetails
DB09063CeritinibapprovednosubstrateinhibitorDetails
DB06469LestaurtinibinvestigationalnoinhibitorDetails
DB11805SaracatinibinvestigationalnoinhibitorDetails
DB11703Acalabrutinibapproved, investigationalunknownsubstrateinhibitorDetails
DB01267PaliperidoneapprovedunknownsubstrateDetails
DB01645GenisteininvestigationalunknowninducerDetails
DB05928DovitinibinvestigationalunknowninhibitorDetails
DB08496(R)-warfarinexperimentalunknownsubstrateDetails
DB119196-O-benzylguanineinvestigationalnosubstrateDetails
DB14583Segesterone acetateapproved, experimental, investigationalunknownsubstrateDetails
DB00563MethotrexateapprovednosubstrateDetails
DB04884DapoxetineinvestigationalnosubstrateinhibitorDetails
DB08953Indalpineinvestigational, withdrawnnosubstrateinhibitorDetails
DB00715Paroxetineapproved, investigationalnosubstrateinhibitorDetails
DB04832Zimelidineapproved, withdrawnnoinhibitorDetails
DB04896Milnacipranapproved, investigationalnosubstrateinhibitorDetails
DB02703Fusidic acidapproved, investigationalunknownsubstrateinhibitorDetails
DB11730Ribociclibapproved, investigationalnosubstrateinhibitorDetails
DB09079NintedanibapprovednosubstrateDetails
DB14634Fluprednidene acetateexperimentalnoinducerDetails
DB14637Fluprednisolone acetateexperimentalnosubstrateDetails
DB01656RoflumilastapprovednosubstrateDetails
DB09034Suvorexantapproved, investigationalnosubstrateDetails
DB09071Tasimelteonapproved, investigationalnosubstrateDetails
DB09030VorapaxarapprovednosubstrateDetails
DB01624Zuclopenthixolapproved, investigationalnosubstrateDetails
DB13385DihydroergocryptineexperimentalnosubstrateDetails
DB11273DihydroergocornineapprovednosubstrateDetails
DB13345Dihydroergocristineapproved, experimentalnosubstrateDetails
DB06218LacosamideapprovednosubstrateDetails
DB12329Eravacyclineapproved, investigationalunknownsubstrateDetails
DB06458RemacemideinvestigationalnoinhibitorDetails
DB08874FidaxomicinapprovednoinhibitorDetails
DB11742Ebastineapproved, investigationalnosubstrateDetails
DB09036Siltuximabapproved, investigationalnoinducerDetails
DB06273TocilizumabapprovednoinducerDetails
DB12301Doravirineapproved, investigationalunknownsubstrateDetails
DB11952Duvelisibapproved, investigationalnosubstrateDetails
DB13997Baloxavir marboxilapproved, investigationalnosubstrateinhibitorDetails
DB00186LorazepamapprovednosubstrateDetails
DB125159-aminocamptothecininvestigationalnosubstrateDetails
DB12952Methylprednisoneapproved, investigationalnosubstrateDetails
DB04861Nebivololapproved, investigationalunknownsubstrateDetails
DB11963Dacomitinibapproved, investigationalnosubstrateDetails
DB12141Gilteritinibapproved, investigationalnosubstrateDetails
DB14723Larotrectinibapproved, investigationalnosubstrateDetails
DB125371,2-Benzodiazepineapproved, investigationalunknownsubstrateDetails
DB09017Brotizolaminvestigational, withdrawnunknownsubstrateDetails
DB11094Vitamin Dapproved, nutraceutical, vet_approvednosubstrateDetails
DB01352Aprobarbitalexperimental, illicitunknowninducerDetails
DB00590DoxazosinapprovednosubstrateDetails
DB05482SN-38investigationalunknownsubstrateinhibitorDetails
DB06480PrucaloprideapprovednosubstrateDetails
DB11978Glasdegibapproved, investigationalnosubstrateDetails
DB12582PiperineinvestigationalunknowninhibitorDetails
DB00191Phentermineapproved, illicitnosubstrateDetails
DB12245Triclabendazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00264Metoprololapproved, investigationalnosubstrateDetails
DB11823Esketamineapproved, investigationalunknownsubstrateinducerDetails
DB00163Vitamin Eapproved, nutraceutical, vet_approvedunknownsubstrateinducerDetails
DB12371Siponimodapproved, investigationalunknownsubstrateDetails
DB12147Erdafitinibapproved, investigationalnosubstrateinhibitorinducerDetails
DB09299Tenofovir alafenamideapprovednosubstrateDetails
DB00982IsotretinoinapprovedunknownsubstrateDetails
DB12015Alpelisibapproved, investigationalunknownsubstrateDetails
DB12240Polatuzumab vedotinapproved, investigationalnosubstrateDetails
DB00905Bimatoprostapproved, investigationalunknownsubstrateDetails
DB11942Selinexorapproved, investigationalunknownsubstrateDetails
DB14669Betamethasone phosphateapproved, vet_approvedunknownsubstrateinducerDetails
DB14652Clocortolone acetateexperimentalunknowninducerDetails
DB13843CloprednolexperimentalunknowninducerDetails
DB14681CortisoneexperimentalunknowninducerDetails
DB13003CortivazolinvestigationalunknowninducerDetails
DB13728HalometasoneexperimentalunknowninducerDetails
DB14659Melengestrol acetateexperimentalunknowninducerDetails
DB14644Methylprednisolone hemisuccinateapprovedunknowninducerDetails
DB14633Prednisolone hemisuccinateexperimentalunknowninducerDetails
DB14631Prednisolone phosphateapproved, vet_approvedunknownsubstrateinducerDetails
DB14646Prednisone acetateapproved, experimental, investigationalunknowninducerDetails
DB02520DitiocarbexperimentalunknowninhibitorDetails
DB06731SeproxetineinvestigationalunknowninhibitorDetails
DB00627Niacinapproved, investigational, nutraceuticalunknowninhibitorDetails
DB06282LevocetirizineapprovedunknownsubstrateDetails
DB09173ButyrfentanylillicitunknownsubstrateDetails
DB12978Pexidartinibapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB01551Dihydrocodeineapproved, illicitunknownsubstrateDetails
DB05154PretomanidapprovedunknownsubstrateDetails
DB01395DrospirenoneapprovedunknownsubstrateDetails
DB01611HydroxychloroquineapprovedunknownsubstrateDetails
DB11986Entrectinibapproved, investigationalunknownsubstrateDetails
DB12500Fedratinibapproved, investigationalunknownsubstrateDetails
DB12825Lefamulinapproved, investigationalunknownsubstrateDetails
DB11757Istradefyllineapproved, investigationalunknownsubstrateDetails
DB01319FosamprenavirapprovedunknownsubstrateinhibitorDetails
DB01050IbuprofenapprovednosubstrateDetails
DB15489MexazolamexperimentalunknownsubstrateDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB09288PropacetamolexperimentalunknownsubstrateinducerDetails
DB01233Metoclopramideapproved, investigationalunknownsubstrateDetails
DB11761Tenapanorapproved, investigationalunknownsubstrateDetails
DB14635Curcumin sulfateexperimentalunknowninhibitorDetails
DB14600Edetate disodium anhydrousapproved, vet_approvedunknowninhibitorDetails
DB01217Anastrozoleapproved, investigationalunknownsubstrateinhibitorDetails
DB14575EslicarbazepineapprovedunknowninducerDetails
DB12808Trifaroteneapproved, investigationalunknownsubstrateDetails
DB15444Elexacaftorapproved, investigationalnosubstrateinhibitorDetails
DB15566Prednisolone acetateapproved, vet_approvedunknownsubstrateinducerDetails
DB00557HydroxyzineapprovednosubstrateDetails
DB14240Echinaceaapproved, experimentalunknowninducerDetails
DB11560Lesinuradapproved, investigationalunknowninducerDetails
DB15035Zanubrutinibapproved, investigationalnosubstrateDetails
DB01381Ginkgo bilobaapproved, investigational, nutraceuticalunknowninhibitorinducerDetails
DB13879Glecaprevirapproved, investigationalunknowninhibitorDetails
DB14975Voxelotorapproved, investigationalunknownsubstrateDetails
DB00717NorethisteroneapprovedunknownsubstrateDetails
DB06119Cenobamateapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB13007Enfortumab vedotinapproved, investigationalunknownsubstrateDetails
DB14962Trastuzumab deruxtecanapproved, investigationalunknownsubstrateDetails
DB11951Lemborexantapproved, investigationalunknownsubstrateDetails
DB12941Darolutamideapproved, investigationalunknownsubstrateDetails
DB06077Lumateperoneapproved, investigationalnosubstrateDetails
DB15091Upadacitinibapproved, investigationalnosubstrateDetails
DB15328Ubrogepantapproved, investigationalunknownsubstrateDetails
DB15233Avapritinibapproved, investigationalunknownsubstrateDetails
DB12887Tazemetostatapproved, investigationalunknownsubstrateDetails
DB12457Rimegepantapproved, investigationalnosubstrateinhibitorDetails
DB13609UmifenovirinvestigationalunknownsubstrateDetails
DB11837Osilodrostatapproved, investigationalunknownsubstrateinhibitorDetails
DB14678Norethindrone enanthateexperimentalunknownsubstrateDetails
DB09241Methylene blueapproved, investigationalunknowninhibitorDetails
DB12612Ozanimodapproved, investigationalunknownsubstrateDetails
DB14598Edetate calcium disodium anhydrousapprovedunknowninhibitorDetails
DB11689Selumetinibapproved, investigationalnosubstrateDetails
DB15102Pemigatinibapproved, investigationalnosubstrateDetails
DB14761Remdesivirapproved, investigationalunknownsubstrateinhibitorDetails
DB11791Capmatinibapproved, investigationalunknownsubstrateDetails
DB15685Selpercatinibapproved, investigationalunknownsubstrateDetails
DB14840RipretinibapprovedunknownsubstrateDetails
DB00714Apomorphineapproved, investigationalunknownDetails
DB12674Lurbinectedinapproved, investigationalunknownsubstrateDetails
DB14649Dexamethasone acetateapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00574Fenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateDetails
DB05015Belinostatapproved, investigationalunknownsubstrateDetails
DB11796Fostemsavirapproved, investigationalunknownsubstrateDetails
DB11932Abametapirapproved, investigationalnoinhibitorDetails
DB15305Risdiplamapproved, investigationalunknownsubstrateDetails
DB14881Oliceridineapproved, investigationalnosubstrateDetails
DB12499Clascoteroneapproved, investigationalnoinhibitorDetails
DB15822Pralsetinibapproved, investigationalnosubstrateinhibitorinducerDetails
DB06448Lonafarnibapproved, investigationalunknownsubstrateinhibitorDetails
DB15982BerotralstatapprovednoinhibitorDetails
DB06137Tirbanibulinapproved, investigationalnosubstrateinhibitorDetails
DB14895Vibegronapproved, investigationalnosubstrateDetails
DB00475Chlordiazepoxideapproved, illicit, investigationalunknownsubstrateDetails
DB00752Tranylcypromineapproved, investigationalunknowninhibitorDetails
DB00170Menadioneapproved, nutraceuticalunknowninhibitorDetails
DB05667Levoketoconazoleapproved, investigationalnosubstrateinhibitorinducerDetails
DB00476DuloxetineapprovedunknowninhibitorDetails
DB11693Voclosporinapproved, investigationalunknownsubstrateinhibitorDetails
DB15133Tepotinibapproved, investigationalnosubstrateinhibitorDetails
DB00747Scopolamineapproved, investigationalnosubstrateDetails
DB00330EthambutolapprovedunknowninhibitorDetails
DB14989Umbralisibapproved, investigational, withdrawnunknownsubstrateDetails
DB14984Casimersenapproved, investigationalnoinhibitorDetails
DB00545Pyridostigmineapproved, investigationalnoinducerDetails
DB11800Tivozanibapproved, investigationalunknownsubstrateDetails
DB12016Ponesimodapproved, investigationalunknownsubstrateDetails
DB08995Diosminapproved, investigationalunknowninhibitorDetails
DB05316Pimavanserinapproved, investigationalunknownsubstrateDetails
DB00986Glycopyrroniumapproved, investigational, vet_approvedunknownsubstrateDetails
DB12235Estetrolapproved, investigationalunknownsubstrateDetails
DB16222Loncastuximab tesirineapproved, investigationalunknownDetails
DB11886Infigratinibapproved, investigationalnosubstrateDetails
DB12471Ibrexafungerpapproved, investigationalunknownsubstrateinhibitorDetails
DB12543Samidorphanapproved, investigationalnosubstrateDetails
DB16165Finerenoneapproved, investigationalunknownsubstrateDetails
DB16703Belumosudilapproved, investigationalnosubstrateDetails
DB12130Lorlatinibapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB15463Belzutifanapproved, investigationalnosubstrateDetails
DB12265Fexinidazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB16390Mobocertinibapproved, investigationalunknownsubstrateDetails
DB16732Tisotumab vedotinapprovednosubstrateDetails
DB16098Atogepantapproved, investigationalnosubstrateDetails
DB16226Maralixibatapproved, investigationalnoinhibitorDetails
DB15011Avacopanapproved, investigationalnosubstrateinhibitorinducerDetails
DB12597Asciminibapproved, investigationalnosubstrateinhibitorDetails
DB06234Maribavirapproved, investigationalnosubstrateDetails
DB16691Nirmatrelvirapproved, investigationalnosubstrateinhibitorDetails
DB15031DaridorexantapprovednosubstrateDetails
DB12713Sotagliflozinapproved, investigationalnosubstrateinhibitorinducerDetails
DB14973Abrocitinibapproved, investigationalnosubstrateDetails
DB05467Palovaroteneapproved, investigationalnosubstrateinducerDetails
DB16236Mitapivatapproved, investigationalnosubstrateinducerDetails
DB12834SecnidazoleapprovedunknownsubstrateinhibitorDetails
DB14737Cannabinolexperimental, investigationalunknownsubstrateinhibitorDetails
DB00486Nabiloneapproved, investigationalunknownsubstrateinhibitorDetails
DB06230Nalmefeneapproved, investigational, withdrawnnosubstrateDetails
DB11697Pacritinibapproved, investigationalnosubstrateinhibitorinducerDetails
DB05087Ganaxoloneapproved, investigationalnosubstrateDetails
DB01041Thalidomideapproved, investigational, withdrawnnosubstrateinducerDetails
DB14921Mavacamtenapproved, investigationalnosubstrateinducerDetails
DB09185Viloxazineapproved, investigational, withdrawnnoinhibitorDetails
DB00951Isoniazidapproved, investigationalunknowninhibitorDetails
DB12020Tecovirimatapproved, investigationalnoinducerDetails
DB06083Tapinarofapproved, investigationalnosubstrateDetails
DB01024Mycophenolic acidapproved, investigationalunknownsubstrateDetails
DB10534GrapefruitapprovedunknowninhibitorDetails
DB04951Pirfenidoneapproved, investigationalunknowninhibitorDetails
DB15673Lenacapavirapproved, investigationalnosubstrateinhibitorDetails
DB12095Telotristat ethylapproved, investigationalnoinhibitorinducerDetails
DB15149Futibatinibapproved, investigationalnosubstrateDetails
DB17083LinzagolixapprovednosubstrateDetails
DB11739Vonoprazanapproved, investigationalunknownsubstrateDetails
DB09065CobicistatapprovedyesinhibitorDetails
DB16267Olutasidenibapproved, investigationalnosubstrateinducerDetails
DB15568Adagrasibapproved, investigationalunknownsubstrateinhibitorDetails
DB12236Bexagliflozinapproved, investigationalunknownsubstrateDetails
DB17472Pirtobrutinibapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB06374Elacestrantapproved, investigationalunknownsubstrateDetails
DB11682Daprodustatapproved, investigationalnosubstrateDetails
DB09065CobicistatapprovednosubstrateDetails
DB12548Sparsentanapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB12513Omaveloxoloneapproved, investigationalunknownsubstrateinducerDetails
DB15688Zavegepantapproved, investigationalunknownsubstrateDetails
DB06045Trofinetideapproved, investigationalunknowninhibitorDetails
DB16217Leniolisibapproved, investigationalnosubstrateDetails
DB12255Vadadustatapproved, investigationalunknowndownregulatorDetails
DB14924Ritlecitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB12874Quizartinibapproved, investigationalnosubstrateDetails
DB15490Zuranoloneapproved, experimentalnosubstrateDetails
DB11763Momelotinibapproved, investigationalunknownsubstrateDetails
DB12184Gepironeapproved, investigationalnosubstrateDetails
DB14766EtrasimodapprovednosubstrateDetails
DB15114Vamoroloneapproved, investigationalnosubstrateinducerDetails
DB12218Capivasertibapproved, investigationalnosubstrateDetails
DB16826Repotrectinibapproved, investigationalnosubstrateinhibitorinducerDetails
DB11679Fruquintinibapproved, investigationalnosubstrateDetails
DB12005Nirogacestatapproved, investigationalnosubstrateDetails
DB11995Avatrombopagapproved, investigationalnosubstrateDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00599Thiopentalapproved, vet_approvedunknownsubstrateDetails
DB08930DolutegravirapprovednosubstrateDetails
DB06595Midostaurinapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB11605MyrrhapprovedunknowninducerDetails
DB11691Naldemedineapproved, investigationalnosubstrateDetails
DB13878Pibrentasvirapproved, investigationalunknowninhibitorDetails
DB13879Glecaprevirapproved, investigationalunknownsubstrateinhibitorDetails
DB09205Moxisylyteapproved, investigationalnosubstrateDetails
DB09568Omega-3-carboxylic acidsapproved, investigationalnosubstrateDetails
DB01601LopinavirapprovednoinhibitorDetails
DB01149Nefazodoneapproved, withdrawnnoinhibitorDetails
DB13141Ambroxol acefyllinateexperimental, investigationalnosubstrateDetails
DB11792MirodenafilinvestigationalunknownsubstrateDetails
DB11979Elagolixapproved, investigationalnosubstrateDetails
DB08865Crizotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB11703Acalabrutinibapproved, investigationalunknownsubstrateDetails
DB12267Brigatinibapproved, investigationalunknowninducerDetails
DB12307ForetinibinvestigationalunknownsubstrateDetails
DB12130Lorlatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00780PhenelzineapprovedunknowninhibitorDetails
DB00593EthosuximideapprovedunknownsubstrateDetails
DB01201Rifapentineapproved, investigationalunknowninducerDetails
DB00643Mebendazoleapproved, vet_approvedunknownsubstrateDetails
DB11757Istradefyllineapproved, investigationalunknowninhibitorDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB09212LoxoprofenapprovedunknownsubstrateDetails
DB00635Prednisoneapproved, vet_approvedunknowninducerDetails
DB01222BudesonideapprovedunknownsubstrateinducerDetails
DB00959Methylprednisoloneapproved, vet_approvedunknownsubstrateinducerDetails
DB11951Lemborexantapproved, investigationalunknowninhibitorinducerDetails
DB12887Tazemetostatapproved, investigationalunknownsubstrateDetails
DB14631Prednisolone phosphateapproved, vet_approvedunknowninducerDetails
DB11652Tucatinibapproved, investigationalunknownsubstrateDetails
DB15035Zanubrutinibapproved, investigationalunknownsubstrateDetails
DB15685Selpercatinibapproved, investigationalunknowninhibitorDetails
DB00409Remoxiprideapproved, withdrawnunknowninhibitorDetails
DB15305Risdiplamapproved, investigationalunknowninhibitorDetails
DB06448Lonafarnibapproved, investigationalnosubstrateinhibitorDetails
DB11853Relugolixapproved, investigationalunknownsubstrateinducerDetails
DB01586Ursodeoxycholic acidapproved, investigationalunknowninducerDetails
DB11742Ebastineapproved, investigationalunknownsubstrateDetails
DB15569Sotorasibapproved, investigationalunknownsubstrateDetails
DB04216Quercetinexperimental, investigationalnoinhibitorDetails
DB00647Dextropropoxypheneapproved, illicit, investigational, withdrawnunknowninhibitorDetails
DB00333MethadoneapprovednoinhibitorDetails
DB01167Itraconazoleapproved, investigationalnoinhibitorDetails
DB16536Birch bark extractapproved, experimentalunknowninhibitorDetails
DB12070Letermovirapproved, investigationalnosubstrateinhibitorDetails