Protein ArsC

Details

Name
Protein ArsC
Synonyms
  • Arsenate reductase
  • Arsenical pump modifier
  • Low molecular weight protein-tyrosine-phosphatase
Gene Name
arsC
Organism
Staphylococcus aureus
Amino acid sequence
>lcl|BSEQ0011344|Protein ArsC
MDKKTIYFICTGNSCRSQMAEGWGKEILGEGWNVYSAGIETHGVNPKAIEAMKEVDIDIS
NHTSDLIDNDILKQSDLVVTLCSDADNNCPILPPNVKKEHWGFDDPAGKEWSEFQRVRDE
IKLAIEKFKLR
Number of residues
131
Molecular Weight
14812.62
Theoretical pI
4.68
GO Classification
Functions
arsenate reductase (thioredoxin) activity / protein tyrosine phosphatase activity
Processes
response to arsenic-containing substance
General Function
Protein tyrosine phosphatase activity
Specific Function
Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011345|Protein ArsC (arsC)
ATGGATAAGAAAACAATTTATTTTATATGTACAGGAAACTCTTGTCGTAGCCAAATGGCT
GAAGGTTGGGGAAAGGAAATATTGGGTGAAGGTTGGAATGTCTATTCTGCTGGTATTGAA
ACACATGGTGTTAATCCTAAAGCAATAGAAGCTATGAAAGAAGTAGATATTGATATATCA
AACCATACGTCAGACTTGATTGATAATGATATTTTAAAACAATCAGATTTGGTCGTAACG
TTATGTAGTGATGCAGACAATAATTGTCCTATTTTACCACCAAACGTTAAAAAAGAGCAT
TGGGGTTTTGATGATCCAGCAGGTAAAGAATGGTCAGAATTCCAACGTGTTAGAGACGAG
ATTAAATTAGCTATAGAAAAGTTTAAATTGAGATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A006
UniProtKB Entry NameARSC_STAAU
GenBank Protein ID150729
GenBank Gene IDM86824
General References
  1. Ji G, Silver S: Regulation and expression of the arsenic resistance operon from Staphylococcus aureus plasmid pI258. J Bacteriol. 1992 Jun;174(11):3684-94. [Article]
  2. Ji G, Silver S: Reduction of arsenate to arsenite by the ArsC protein of the arsenic resistance operon of Staphylococcus aureus plasmid pI258. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9474-8. [Article]
  3. Ji G, Garber EA, Armes LG, Chen CM, Fuchs JA, Silver S: Arsenate reductase of Staphylococcus aureus plasmid pI258. Biochemistry. 1994 Jun 14;33(23):7294-9. [Article]
  4. Messens J, Hayburn G, Desmyter A, Laus G, Wyns L: The essential catalytic redox couple in arsenate reductase from Staphylococcus aureus. Biochemistry. 1999 Dec 21;38(51):16857-65. [Article]
  5. Messens J, Martins JC, Brosens E, Van Belle K, Jacobs DM, Willem R, Wyns L: Kinetics and active site dynamics of Staphylococcus aureus arsenate reductase. J Biol Inorg Chem. 2002 Jan;7(1-2):146-56. Epub 2001 Jul 24. [Article]
  6. Zegers I, Martins JC, Willem R, Wyns L, Messens J: Arsenate reductase from S. aureus plasmid pI258 is a phosphatase drafted for redox duty. Nat Struct Biol. 2001 Oct;8(10):843-7. [Article]
  7. Messens J, Martins JC, Van Belle K, Brosens E, Desmyter A, De Gieter M, Wieruszeski JM, Willem R, Wyns L, Zegers I: All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8506-11. Epub 2002 Jun 18. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB027635-Mercapto-2-Nitro-Benzoic AcidexperimentalunknownDetails
DB03138PerchlorateexperimentalunknownDetails
DB03352S-ArsonocysteineexperimentalunknownDetails