Purine nucleoside phosphorylase

Details

Name
Purine nucleoside phosphorylase
Synonyms
  • 2.4.2.1
  • deoD
  • Inosine phosphorylase
  • Inosine-guanosine phosphorylase
  • PNP
Gene Name
punA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051177|Purine nucleoside phosphorylase
MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGF
VPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNA
AGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVY
AGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEP
LSHAEVLAAGAASATRMGALLADVIARF
Number of residues
268
Molecular Weight
27571.215
Theoretical pI
Not Available
GO Classification
Functions
purine-nucleoside phosphorylase activity
Processes
deoxyguanosine catabolic process
General Function
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
Specific Function
Purine-nucleoside phosphorylase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051178|Purine nucleoside phosphorylase (punA)
GTGGCTGACCCGCGCCCCGATCCCGACGAACTGGCCCGGCGGGCGGCGCAGGTCATCGCT
GACCGCACCGGGATCGGCGAACATGACGTCGCGGTCGTGCTCGGGTCGGGATGGTTACCG
GCCGTTGCGGCGTTGGGCTCCCCGACCACCGTGCTGCCGCAGGCCGAACTGCCCGGGTTT
GTGCCGCCAACCGCAGCCGGGCATGCGGGCGAGCTACTGTCCGTGCCCATCGGTGCGCAC
CGGGTGCTGGTGCTGGCCGGTCGCATCCACGCCTACGAGGGACACGACCTGCGCTACGTC
GTGCATCCGGTTCGGGCGGCCCGTGCGGCAGGGGCGCAGATTATGGTGCTCACCAACGCC
GCCGGTGGGCTGCGGGCGGACCTTCAGGTCGGCCAGCCGGTGCTGATCAGCGATCACCTG
AACCTGACCGCACGTTCGCCACTGGTTGGCGGGGAGTTCGTCGACCTGACCGACGCCTAC
TCACCGCGACTGCGGGAACTCGCCCGCCAATCCGACCCGCAGCTGGCCGAAGGCGTCTAC
GCCGGCCTGCCGGGGCCGCACTACGAGACACCGGCGGAGATCCGGATGTTGCAGACACTG
GGCGCCGACCTGGTCGGCATGTCCACGGTGCACGAGACCATCGCGGCCCGGGCGGCGGGC
GCTGAGGTACTGGGCGTATCCCTGGTGACAAATCTGGCGGCCGGGATCACCGGCGAGCCG
CTGAGCCACGCCGAGGTGCTCGCCGCCGGAGCCGCATCGGCGACTCGGATGGGCGCGCTG
CTAGCCGACGTGATCGCCCGGTTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WP01
UniProtKB Entry NamePUNA_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  3. Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL: Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry. 2001 Jul 27;40(28):8204-15. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB034112-Hydroxymethyl-Pyrrolidine-3,4-DiolexperimentalunknownDetails
DB03551(3R,4R)-3-Hydroxy-4-(hydroxymethyl)-1-[(4-oxo-4,4a,5,7a-tetrahydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]pyrrolidiniumexperimentalunknownDetails
DB040959-DeazahypoxanthineexperimentalunknownDetails