3-oxoacyl-[acyl-carrier-protein] synthase 3

Details

Name
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms
  • 2.3.1.180
  • 3-oxoacyl-[acyl-carrier-protein] synthase III
  • Beta-ketoacyl-ACP synthase III
  • KAS III
  • MtFabH
Gene Name
fabH
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051249|3-oxoacyl-[acyl-carrier-protein] synthase 3
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
Number of residues
335
Molecular Weight
34872.13
Theoretical pI
Not Available
GO Classification
Functions
3-oxoacyl-[acyl-carrier-protein] synthase activity / beta-ketoacyl-acyl-carrier-protein synthase III activity / fatty-acyl-CoA binding
Processes
fatty acid biosynthetic process / fatty acid elongation / lipid biosynthetic process / long-chain fatty-acyl-CoA metabolic process
Components
cytoplasm
General Function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall.
Specific Function
3-oxoacyl-[acyl-carrier-protein] synthase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051250|3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)
ATGACGGAGATCGCCACGACCAGCGGCGCCAGGAGCGTCGGGCTGCTCAGTGTCGGGGCG
TACCGGCCCGAACGCGTGGTCACCAACGACGAGATATGCCAGCACATCGACTCGTCCGAC
GAGTGGATCTACACCCGAACCGGCATCAAGACCCGCCGATTCGCCGCCGACGACGAGTCG
GCGGCTTCCATGGCGACTGAGGCCTGTCGACGGGCACTGTCGAACGCCGGCCTGTCGGCG
GCCGACATCGATGGCGTGATCGTCACCACCAACACCCATTTCCTGCAAACCCCGCCGGCC
GCCCCAATGGTCGCGGCGTCGCTGGGCGCCAAGGGCATACTCGGGTTCGATCTTTCGGCG
GGGTGCGCCGGATTCGGATATGCGCTTGGCGCAGCGGCCGACATGATCCGGGGCGGAGGT
GCGGCCACGATGCTGGTGGTCGGCACGGAAAAACTGTCCCCCACGATAGACATGTACGAC
CGCGGCAACTGCTTCATCTTCGCCGACGGCGCGGCCGCAGTGGTGGTGGGCGAGACACCG
TTTCAAGGCATTGGACCAACCGTGGCGGGTAGCGACGGCGAACAGGCCGATGCCATACGG
CAGGACATCGACTGGATCACTTTCGCCCAGAATCCCAGCGGCCCACGCCCGTTTGTGCGG
CTCGAAGGTCCCGCGGTCTTCCGTTGGGCAGCGTTCAAAATGGGCGACGTCGGTCGGCGC
GCGATGGACGCCGCCGGGGTGCGACCCGACCAGATAGACGTGTTCGTCCCTCATCAGGCC
AATAGCCGCATCAACGAGCTGCTGGTCAAGAACCTGCAGTTGCGGCCCGACGCGGTGGTC
GCCAACGATATCGAGCACACCGGAAACACCTCGGCGGCCTCCATTCCGCTCGCGATGGCC
GAATTACTGACGACCGGCGCGGCCAAGCCCGGCGATCTGGCCCTGTTGATCGGCTACGGC
GCCGGTCTGAGCTATGCCGCCCAGGTGGTGCGAATGCCGAAGGGTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WNG3
UniProtKB Entry NameFABH_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Choi KH, Kremer L, Besra GS, Rock CO: Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem. 2000 Sep 8;275(36):28201-7. [Article]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT: Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem. 2001 Jun 8;276(23):20516-22. Epub 2001 Mar 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03017Lauric acidapproved, experimentalunknownDetails
DB03264Dodecyl-CoaexperimentalunknownDetails
DB07611DECANE-1-THIOLexperimentalunknownDetails
DB07650Decyl formateexperimentalunknownDetails
DB0817111-MERCAPTOUNDECANOIC ACIDexperimentalunknownDetails
DB08684O-Decyl Hydrogen ThiocarbonateexperimentalunknownDetails
DB0871211-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACIDexperimentalunknownDetails