3-oxoacyl-[acyl-carrier-protein] synthase 3
Details
- Name
- 3-oxoacyl-[acyl-carrier-protein] synthase 3
- Synonyms
- 2.3.1.180
- 3-oxoacyl-[acyl-carrier-protein] synthase III
- Beta-ketoacyl-ACP synthase III
- KAS III
- MtFabH
- Gene Name
- fabH
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051249|3-oxoacyl-[acyl-carrier-protein] synthase 3 MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
- Number of residues
- 335
- Molecular Weight
- 34872.13
- Theoretical pI
- Not Available
- GO Classification
- Functions3-oxoacyl-[acyl-carrier-protein] synthase activity / beta-ketoacyl-acyl-carrier-protein synthase III activity / fatty-acyl-CoA bindingProcessesfatty acid biosynthetic process / fatty acid elongation / lipid biosynthetic process / long-chain fatty-acyl-CoA metabolic processComponentscytoplasm
- General Function
- Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall.
- Specific Function
- 3-oxoacyl-[acyl-carrier-protein] synthase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051250|3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH) ATGACGGAGATCGCCACGACCAGCGGCGCCAGGAGCGTCGGGCTGCTCAGTGTCGGGGCG TACCGGCCCGAACGCGTGGTCACCAACGACGAGATATGCCAGCACATCGACTCGTCCGAC GAGTGGATCTACACCCGAACCGGCATCAAGACCCGCCGATTCGCCGCCGACGACGAGTCG GCGGCTTCCATGGCGACTGAGGCCTGTCGACGGGCACTGTCGAACGCCGGCCTGTCGGCG GCCGACATCGATGGCGTGATCGTCACCACCAACACCCATTTCCTGCAAACCCCGCCGGCC GCCCCAATGGTCGCGGCGTCGCTGGGCGCCAAGGGCATACTCGGGTTCGATCTTTCGGCG GGGTGCGCCGGATTCGGATATGCGCTTGGCGCAGCGGCCGACATGATCCGGGGCGGAGGT GCGGCCACGATGCTGGTGGTCGGCACGGAAAAACTGTCCCCCACGATAGACATGTACGAC CGCGGCAACTGCTTCATCTTCGCCGACGGCGCGGCCGCAGTGGTGGTGGGCGAGACACCG TTTCAAGGCATTGGACCAACCGTGGCGGGTAGCGACGGCGAACAGGCCGATGCCATACGG CAGGACATCGACTGGATCACTTTCGCCCAGAATCCCAGCGGCCCACGCCCGTTTGTGCGG CTCGAAGGTCCCGCGGTCTTCCGTTGGGCAGCGTTCAAAATGGGCGACGTCGGTCGGCGC GCGATGGACGCCGCCGGGGTGCGACCCGACCAGATAGACGTGTTCGTCCCTCATCAGGCC AATAGCCGCATCAACGAGCTGCTGGTCAAGAACCTGCAGTTGCGGCCCGACGCGGTGGTC GCCAACGATATCGAGCACACCGGAAACACCTCGGCGGCCTCCATTCCGCTCGCGATGGCC GAATTACTGACGACCGGCGCGGCCAAGCCCGGCGATCTGGCCCTGTTGATCGGCTACGGC GCCGGTCTGAGCTATGCCGCCCAGGTGGTGCGAATGCCGAAGGGTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WNG3 UniProtKB Entry Name FABH_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Choi KH, Kremer L, Besra GS, Rock CO: Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. J Biol Chem. 2000 Sep 8;275(36):28201-7. [Article]
- Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT: Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem. 2001 Jun 8;276(23):20516-22. Epub 2001 Mar 8. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03017 Lauric acid approved, experimental unknown Details DB03264 Dodecyl-Coa experimental unknown Details DB07611 DECANE-1-THIOL experimental unknown Details DB07650 Decyl formate experimental unknown Details DB08171 11-MERCAPTOUNDECANOIC ACID experimental unknown Details DB08684 O-Decyl Hydrogen Thiocarbonate experimental unknown Details DB08712 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID experimental unknown Details