N-acetylneuraminate lyase

Details

Name
N-acetylneuraminate lyase
Synonyms
  • 4.1.3.3
  • N-acetylneuraminate pyruvate-lyase
  • N-acetylneuraminic acid aldolase
  • NAL
  • NALase
  • Sialate lyase
  • Sialic acid aldolase
  • Sialic acid lyase
Gene Name
nanA
Organism
Shigella flexneri
Amino acid sequence
>lcl|BSEQ0011174|N-acetylneuraminate lyase
MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSERE
QVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCD
HYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRRE
HPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECN
KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
Number of residues
297
Molecular Weight
32593.23
Theoretical pI
5.69
GO Classification
Functions
N-acetylneuraminate lyase activity
Processes
carbohydrate metabolic process / N-acetylneuraminate catabolic process
Components
cytoplasm
General Function
N-acetylneuraminate lyase activity
Specific Function
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011175|N-acetylneuraminate lyase (nanA)
ATGGCAACGAATTTACGTGGCGTAATGGCTGCACTCCTGACTCCTTTTGATCAACAACAA
GCACTGGATAAAGCGAGTCTGCGCCGCCTGGTTCAGTTCAATATTCAGCAGGGCATCGAC
GGTTTATACGTGGGTGGTTCGACCGGCGAAGCCTTTGTACAAAGCCTTTCCGAGCGTGAA
CAGGTACTGGAAATCGTCGCCGAAGAGGCGAAAGGTAAGATTAAACTCATCGCCCACGTC
GGTTGCGTCAGCACCGCCGAAAGCCAACAACTTGCGGCATCGGCTAAACGTTATGGCTTC
GATGCCGTCTCCGCCGTCACGCCGTTCTACTATCCTTTCAGCTTTGAAGAACACTGCGAT
CACTATCGGGCAATTATTGATTCAGCGGATGGTTTGCCGATGGTGGTGTACAACATTCCA
GCCCTGAGTGGGGTAAAACTGACCCTGGATCAGATCAACACCCTGGTTACGTTGCCTGGC
GTCGGTGCGCTGAAACAGACTTCTGGCGATCTCTATCAGATGGAACAGATCCGTCGTGAA
CATCCTGATCTGGTGCTCTATAACGGTTACGACGAAATCTTCGCTTCCGGCTTGCTGGCA
GGCGCTGATGGTGGTATCGGCAGTACTTACAACATCATGGGCTGGCGATATCAGGGGATC
GTGAAGGCGCTGAAAGAAGGCGATATCCAGACCGCGCAGAAACTGCAAACTGAGTGCAAC
AAAGTCATTGATTTACTGATCAAAACGGGCGTATTCCGCGGCCTGAAAACTGTCCTGCAT
TATATGGATGTCGTTTCTGTGCCGCTGTGCCGCAAACCGTTTGGACCGGTAGATGAAAAA
TATCTGCCAGAACTGAAGGCGCTGGCCCAGCAGTTGATGCAAGAGCGCGGGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A6L6
UniProtKB Entry NameNANA_SHIFL
GenBank Protein ID24053696
GenBank Gene IDAE005674
General References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB029513-Hydroxypyruvic AcidexperimentalunknownDetails