Acyl-CoA thioesterase 2

Details

Name

Acyl-CoA thioesterase 2

Synonyms

• 3.1.2.-
• Acyl-CoA thioesterase II
• TEII

Gene Name

tesB

Organism

Escherichia coli (strain K12)

Amino acid sequence

>lcl|BSEQ0011471|Acyl-CoA thioesterase 2
MSQALKNLLTLLNLEKIEEGLFRGQSEDLGLRQVFGGQVVGQALYAAKETVPEERLVHSF
HSYFLRPGDSKKPIIYDVETLRDGNSFSARRVAAIQNGKPIFYMTASFQAPEAGFEHQKT
MPSAPAPDGLPSETQIAQSLAHLLPPVLKDKFICDRPLEVRPVEFHNPLKGHVAEPHRQV
WIRANGSVPDDLRVHQYLLGYASDLNFLPVALQPHGIGFLEPGIQIATIDHSMWFHRPFN
LNEWLLYSVESTSASSARGFVRGEFYTQDGVLVASTVQEGVMRNHN

Number of residues

286

Molecular Weight

31966.095

Theoretical pI

6.65

GO Classification

Functions

acyl-CoA hydrolase activity

Processes

acyl-CoA metabolic process / fatty acid catabolic process

Components

cytosol

General Function

Acyl-coa hydrolase activity

Specific Function

Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known.

Pfam Domain Function

• Acyl_CoA_thio (PF02551)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasmic

Gene sequence

>lcl|BSEQ0011472|Acyl-CoA thioesterase 2 (tesB)
ATGAGTCAGGCGCTAAAAAATTTACTGACATTGTTAAATCTGGAAAAAATTGAGGAAGGA
CTCTTTCGCGGCCAGAGTGAAGATTTAGGTTTACGCCAGGTGTTTGGCGGCCAGGTCGTG
GGTCAGGCCTTGTATGCTGCAAAAGAGACCGTCCCTGAAGAGCGGCTGGTACATTCGTTT
CACAGCTACTTTCTTCGCCCTGGCGATAGTAAGAAGCCGATTATTTATGATGTCGAAACG
CTGCGTGACGGTAACAGCTTCAGCGCCCGCCGGGTTGCTGCTATTCAAAACGGCAAACCG
ATTTTTTATATGACTGCCTCTTTCCAGGCACCAGAAGCGGGTTTCGAACATCAAAAAACA
ATGCCGTCCGCGCCAGCGCCTGATGGCCTCCCTTCGGAAACGCAAATCGCCCAATCGCTG
GCGCACCTGCTGCCGCCAGTGCTGAAAGATAAATTCATCTGCGATCGTCCGCTGGAAGTC
CGTCCGGTGGAGTTTCATAACCCACTGAAAGGTCACGTCGCAGAACCACATCGTCAGGTG
TGGATCCGCGCAAATGGTAGCGTGCCGGATGACCTGCGCGTTCATCAGTATCTGCTCGGT
TACGCTTCTGATCTTAACTTCCTGCCGGTAGCTCTACAGCCGCACGGCATCGGTTTTCTC
GAACCGGGGATTCAGATTGCCACCATTGACCATTCCATGTGGTTCCATCGCCCGTTTAAT
TTGAATGAATGGCTGCTGTATAGCGTGGAGAGCACCTCGGCGTCCAGCGCACGTGGCTTT
GTGCGCGGTGAGTTTTATACCCAAGACGGCGTACTGGTTGCCTCGACCGTTCAGGAAGGG
GTGATGCGTAATCACAATTAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P0AGG2
UniProtKB Entry Name	TESB_ECOLI
GenBank Protein ID	147932
GenBank Gene ID	M63308

General References

1. Naggert J, Narasimhan ML, DeVeaux L, Cho H, Randhawa ZI, Cronan JE Jr, Green BN, Smith S: Cloning, sequencing, and characterization of Escherichia coli thioesterase II. J Biol Chem. 1991 Jun 15;266(17):11044-50. [Article]
2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
4. Li J, Derewenda U, Dauter Z, Smith S, Derewenda ZS: Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme. Nat Struct Biol. 2000 Jul;7(7):555-9. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04147	Dodecyldimethylamine N-oxide	experimental	unknown		Details