Interleukin-8

Details

Name
Interleukin-8
Synonyms
  • C-X-C motif chemokine 8
  • Chemokine (C-X-C motif) ligand 8
  • Emoctakin
  • GCP-1
  • Granulocyte chemotactic protein 1
  • IL-8
  • IL8
  • MDNCF
  • MONAP
  • Monocyte-derived neutrophil chemotactic factor
  • Monocyte-derived neutrophil-activating peptide
  • NAP-1
  • Neutrophil-activating protein 1
  • Protein 3-10C
  • T-cell chemotactic factor
Gene Name
CXCL8
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001913|Interleukin-8
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
Number of residues
99
Molecular Weight
11097.98
Theoretical pI
9.09
GO Classification
Functions
chemokine activity / interleukin-8 receptor binding
Processes
angiogenesis / calcium-mediated signaling / cell cycle arrest / cellular protein metabolic process / cellular response to fibroblast growth factor stimulus / cellular response to interleukin-1 / cellular response to lipopolysaccharide / cellular response to tumor necrosis factor / chemokine-mediated signaling pathway / chemotaxis / embryonic digestive tract development / endoplasmic reticulum unfolded protein response / G-protein coupled receptor signaling pathway / immune response / induction of positive chemotaxis / inflammatory response / intracellular signal transduction / movement of cell or subcellular component / negative regulation of cell proliferation / negative regulation of G-protein coupled receptor protein signaling pathway / neutrophil activation / neutrophil chemotaxis / PERK-mediated unfolded protein response / positive regulation of angiogenesis / positive regulation of neutrophil chemotaxis / receptor internalization / regulation of cell adhesion / regulation of single stranded viral RNA replication via double stranded DNA intermediate / response to endoplasmic reticulum stress / response to molecule of bacterial origin / signal transduction
Components
extracellular region / extracellular space / intracellular
General Function
Interleukin-8 receptor binding
Specific Function
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010675|Interleukin-8 (CXCL8)
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA
Chromosome Location
4
Locus
4q13-q21
External Identifiers
ResourceLink
UniProtKB IDP10145
UniProtKB Entry NameIL8_HUMAN
GenBank Protein ID34519
GenBank Gene IDY00787
GenAtlas IDIL8
HGNC IDHGNC:6025
General References
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  8. Van Damme J, Van Beeumen J, Conings R, Decock B, Billiau A: Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin. Eur J Biochem. 1989 May 1;181(2):337-44. [Article]
  9. Van Damme J, Rampart M, Conings R, Decock B, Van Osselaer N, Willems J, Billiau A: The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. Eur J Immunol. 1990 Sep;20(9):2113-8. [Article]
  10. Yoshimura T, Robinson EA, Appella E, Matsushima K, Showalter SD, Skeel A, Leonard EJ: Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence. Mol Immunol. 1989 Jan;26(1):87-93. [Article]
  11. Suzuki K, Miyasaka H, Ota H, Yamakawa Y, Tagawa M, Kuramoto A, Mizuno S: Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. J Exp Med. 1989 Jun 1;169(6):1895-901. [Article]
  12. Schroder JM: Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale. Adv Exp Med Biol. 1991;305:97-107. [Article]
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  14. Suzuki K, Yamakawa Y, Matsuo Y, Kamiya T, Minowada J, Mizuno S: Isolation and amino acid sequence of a chemotactic protein, LECT/interleukin 8, from a human myeloid leukemia cell line, ML-1. Immunol Lett. 1993 Apr;36(1):71-81. [Article]
  15. Gregory H, Young J, Schroder JM, Mrowietz U, Christophers E: Structure determination of a human lymphocyte derived neutrophil activating peptide (LYNAP). Biochem Biophys Res Commun. 1988 Mar 15;151(2):883-90. [Article]
  16. Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ: Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9233-7. [Article]
  17. Walz A, Peveri P, Aschauer H, Baggiolini M: Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun. 1987 Dec 16;149(2):755-61. [Article]
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  27. Clore GM, Appella E, Yamada M, Matsushima K, Gronenborn AM: Determination of the secondary structure of interleukin-8 by nuclear magnetic resonance spectroscopy. J Biol Chem. 1989 Nov 15;264(32):18907-11. [Article]
  28. Clore GM, Appella E, Yamada M, Matsushima K, Gronenborn AM: Three-dimensional structure of interleukin 8 in solution. Biochemistry. 1990 Feb 20;29(7):1689-96. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05434ABT-510investigationalunknownDetails
DB05484MDX-018investigationalunknownDetails
DB05855RivaniclineinvestigationalunknownantagonistDetails
DB12843Oleandrinexperimental, investigationalunknowninhibitorDetails