Cytochrome P450 2D6

Details

Name
Cytochrome P450 2D6
Synonyms
  • 1.14.14.1
  • Cholesterol 25-hydroxylase
  • CYP2DL1
  • CYPIID6
  • Cytochrome P450-DB1
  • Debrisoquine 4-hydroxylase
Gene Name
CYP2D6
Organism
Human
Amino acid sequence
>lcl|BSEQ0004641|Cytochrome P450 2D6
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Number of residues
497
Molecular Weight
55768.94
Theoretical pI
7.26
GO Classification
Functions
drug binding / oxidoreductase activity / iron ion binding / heme binding / arachidonic acid epoxygenase activity / monooxygenase activity / steroid hydroxylase activity / aromatase activity / oxygen binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Processes
drug catabolic process / small molecule metabolic process / heterocycle metabolic process / oxidation-reduction process / monoterpenoid metabolic process / steroid metabolic process / oxidative demethylation / xenobiotic metabolic process / arachidonic acid metabolic process / drug metabolic process / coumarin metabolic process / exogenous drug catabolic process / negative regulation of binding / alkaloid catabolic process / isoquinoline alkaloid metabolic process / negative regulation of cellular organofluorine metabolic process / alkaloid metabolic process
Components
cytoplasm / mitochondrion / endoplasmic reticulum / endoplasmic reticulum membrane
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019275|Cytochrome P450 2D6 (CYP2D6)
ATGGGGCTAGAAGCACTGGTGCCCCTGGCCGTGATAGTGGCCATCTTCCTGCTCCTGGTG
GACCTGATGCACCGGCGCCAACGCTGGGCTGCACGCTACCCACCAGGCCCCCTGCCACTG
CCCGGGCTGGGCAACCTGCTGCATGTGGACTTCCAGAACACACCATACTGCTTCGACCAG
TTGCGGCGCCGCTTCGGGGACGTGTTCAGCCTGCAGCTGGCCTGGACGCCGGTGGTCGTG
CTCAATGGGCTGGCGGCCGTGCGCGAGGCGCTGGTGACCCACGGCGAGGACACCGCCGAC
CGCCCGCCTGTGCCCATCACCCAGATCCTGGGTTTCGGGCCGCGTTCCCAAGGGGTGTTC
CTGGCGCGCTATGGGCCCGCGTGGCGCGAGCAGAGGCGCTTCTCCGTGTCCACCTTGCGC
AACTTGGGCCTGGGCAAGAAGTCGCTGGAGCAGTGGGTGACCGAGGAGGCCGCCTGCCTT
TGTGCCGCCTTCGCCAACCACTCCGGACGCCCCTTTCGCCCCAACGGTCTCTTGGACAAA
GCCGTGAGCAACGTGATCGCCTCCCTCACCTGCGGGCGCCGCTTCGAGTACGACGACCCT
CGCTTCCTCAGGCTGCTGGACCTAGCTCAGGAGGGACTGAAGGAGGAGTCGGGCTTTCTG
CGCGAGGTGCTGAATGCTGTCCCCGTCCTCCTGCATATCCCAGCGCTGGCTGGCAAGGTC
CTACGCTTCCAAAAGGCTTTCCTGACCCAGCTGGATGAGCTGCTAACTGAGCACAGGATG
ACCTGGGACCCAGCCCAGCCCCCCCGAGACCTGACTGAGGCCTTCCTGGCAGAGATGGAG
AAGGCCAAGGGGAACCCTGAGAGCAGCTTCAATGATGAGAACCTGCGCATAGTGGTGGCT
GACCTGTTCTCTGCCGGGATGGTGACCACCTCGACCACGCTGGCCTGGGGCCTCCTGCTC
ATGATCCTACATCCGGATGTGCAGCGCCGTGTCCAACAGGAGATCGACGACGTGATAGGG
CAGGTGCGGCGACCAGAGATGGGTGACCAGGCTCACATGCCCTACACCACTGCCGTGATT
CATGAGGTGCAGCGCTTTGGGGACATCGTCCCCCTGGGTGTGACCCATATGACATCCCGT
GACATCGAAGTACAGGGCTTCCGCATCCCTAAGGGAACGACACTCATCACCAACCTGTCA
TCGGTGCTGAAGGATGAGGCCGTCTGGGAGAAGCCCTTCCGCTTCCACCCCGAACACTTC
CTGGATGCCCAGGGCCACTTTGTGAAGCCGGAGGCCTTCCTGCCTTTCTCAGCAGGCCGC
CGTGCATGCCTCGGGGAGCCCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTCCCTG
CTGCAGCACTTCAGCTTCTCGGTGCCCACTGGACAGCCCCGGCCCAGCCACCATGGTGTC
TTTGCTTTCCTGGTGAGCCCATCCCCCTATGAGCTTTGTGCTGTGCCCCGCTAG
Chromosome Location
22
Locus
22q13.1
External Identifiers
ResourceLink
UniProtKB IDP10635
UniProtKB Entry NameCP2D6_HUMAN
GenBank Protein ID181350
GenBank Gene IDM20403
GenAtlas IDCYP2D6
HGNC IDHGNC:2625
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00176Fluvoxamineapproved, investigationalunknownsubstrateinhibitorDetails
DB00182Amphetamineapproved, illicitunknownsubstrateinhibitorDetails
DB00185CevimelineapprovedunknownsubstrateDetails
DB00193Tramadolapproved, investigationalunknownsubstrateinhibitorDetails
DB00243Ranolazineapproved, investigationalunknowninhibitorDetails
DB00264Metoprololapproved, investigationalunknownsubstrateinhibitorDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00285VenlafaxineapprovedunknownsubstrateinhibitorDetails
DB00289AtomoxetineapprovedunknownsubstrateinhibitorDetails
DB00295Morphineapproved, investigationalunknownsubstrateDetails
DB00318Codeineapproved, illicitunknownsubstrateinhibitorDetails
DB00332Ipratropium bromideapprovedunknownsubstrateDetails
DB00370MirtazapineapprovedunknownsubstrateinhibitorinducerDetails
DB00373TimololapprovedunknownsubstrateinhibitorDetails
DB00379MexiletineapprovedunknownsubstrateDetails
DB00433Prochlorperazineapproved, vet_approvedunknownsubstrateDetails
DB00454PethidineapprovedunknownsubstrateDetails
DB00476DuloxetineapprovedunknownsubstrateinhibitorDetails
DB00477Chlorpromazineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00496Darifenacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00497Oxycodoneapproved, illicit, investigationalunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateinhibitorinducerDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinhibitorDetails
DB00514DextromethorphanapprovedunknownsubstrateinhibitorDetails
DB00521CarteololapprovedunknownsubstrateinhibitorDetails
DB00557HydroxyzineapprovedunknowninhibitorDetails
DB00574Fenfluramineillicit, investigational, withdrawnunknowninhibitorDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB00612BisoprololapprovedunknownsubstrateDetails
DB00623FluphenazineapprovedunknownsubstrateinhibitorDetails
DB00647Dextropropoxypheneapproved, illicit, investigational, withdrawnunknowninhibitorDetails
DB00656Trazodoneapproved, investigationalunknownsubstrateDetails
DB00674GalantamineapprovedunknownsubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorDetails
DB00679Thioridazineapproved, withdrawnunknownsubstrateinhibitorDetails
DB00699Nicergolineapproved, investigationalunknownsubstrateDetails
DB00715Paroxetineapproved, investigationalunknownsubstrateinhibitorDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateinhibitorDetails
DB00757DolasetronapprovedunknownsubstrateinhibitorDetails
DB00805MinaprineapprovedunknownsubstrateDetails
DB00843DonepezilapprovedunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateinhibitorDetails
DB00863RanitidineapprovedunknownsubstrateinhibitorDetails
DB00866Alprenololapproved, withdrawnunknownsubstrateDetails
DB00904OndansetronapprovedunknownsubstrateinhibitorDetails
DB00914Phenforminapproved, investigational, withdrawnunknownsubstrateDetails
DB00918Almotriptanapproved, investigationalunknownsubstrateDetails
DB00934MaprotilineapprovedunknownsubstrateDetails
DB00956Hydrocodoneapproved, illicitunknownsubstrateDetails
DB00960PindololapprovedunknownsubstrateinhibitorinducerDetails
DB00983Formoterolapproved, investigationalunknownsubstrateDetails
DB01012CinacalcetapprovedunknowninhibitorDetails
DB01035ProcainamideapprovedunknownsubstrateDetails
DB01036Tolterodineapproved, investigationalunknownsubstrateDetails
DB01069PromethazineapprovedunknownsubstrateinhibitorDetails
DB01074Perhexilineapproved, investigationalunknownsubstrateinhibitorDetails
DB01114ChlorphenamineapprovedunknownsubstrateinhibitorDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01142DoxepinapprovedunknownsubstrateinhibitorDetails
DB01151DesipramineapprovedunknownsubstrateinhibitorDetails
DB01193AcebutololapprovedunknowninhibitorDetails
DB01195Flecainideapproved, withdrawnunknownsubstrateinhibitorDetails
DB01197CaptoprilapprovedunknownsubstrateDetails
DB01228Encainideapproved, investigational, withdrawnunknownsubstrateDetails
DB01233Metoclopramideapproved, investigationalunknownsubstrateinhibitorDetails
DB01242Clomipramineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01171MoclobemideapprovedunknownsubstrateinhibitorinducerDetails
DB01274Arformoterolapproved, investigationalunknownsubstrateDetails
DB01410Ciclesonideapproved, investigationalunknownDetails
DB01466Ethylmorphineapproved, illicitunknownsubstrateDetails
DB01409TiotropiumapprovedunknownsubstrateDetails
DB01075DiphenhydramineapprovedunknownsubstrateinhibitorDetails
DB04840Debrisoquinapproved, investigationalunknownsubstrateDetails
DB00215CitalopramapprovedunknownsubstrateinhibitorDetails
DB00234Reboxetineapproved, investigationalunknowninhibitorinducerDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateinhibitorDetails
DB00327Hydromorphoneapproved, illicitunknownsubstrateDetails
DB00342TerfenadinewithdrawnunknownsubstrateinhibitorDetails
DB00343DiltiazemapprovedunknownsubstrateinhibitorDetails
DB00356ChlorzoxazoneapprovedunknownsubstrateDetails
DB00363ClozapineapprovedunknownsubstrateinhibitorDetails
DB00455LoratadineapprovedunknownsubstrateinhibitorinducerDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00468QuinineapprovedunknownsubstrateinhibitorDetails
DB00482Celecoxibapproved, investigationalunknowninhibitorDetails
DB00501CimetidineapprovedunknowninhibitorDetails
DB00532Mephenytoininvestigational, withdrawnunknownsubstrateDetails
DB00540NortriptylineapprovedunknownsubstrateinhibitorDetails
DB00613Amodiaquineapproved, investigationalunknowninhibitorDetails
DB00622NicardipineapprovedunknownsubstrateinhibitorDetails
DB00705DelavirdineapprovedunknownsubstrateinhibitorDetails
DB00726TrimipramineapprovedunknownsubstrateDetails
DB00752TranylcypromineapprovedunknowninhibitorDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00908QuinidineapprovedunknowninhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00933Mesoridazineapproved, investigationalunknownsubstrateDetails
DB00967Desloratadineapproved, investigationalunknowninhibitorDetails
DB00972AzelastineapprovedunknownsubstrateinhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01071MequitazineapprovedunknownsubstrateDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorDetails
DB01118Amiodaroneapproved, investigationalunknownsubstrateinhibitorDetails
DB01131ProguanilapprovedunknowninhibitorDetails
DB01149Nefazodoneapproved, withdrawnunknownsubstrateinhibitorDetails
DB01156BupropionapprovedunknownsubstrateinhibitorDetails
DB01167Itraconazoleapproved, investigationalunknowninhibitorDetails
DB01175Escitalopramapproved, investigationalunknownsubstrateinhibitorDetails
DB01182PropafenoneapprovedunknownsubstrateinhibitorDetails
DB01191Dexfenfluramineapproved, illicit, investigational, withdrawnunknownsubstrateinhibitorDetails
DB01192Oxymorphoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB01218HalofantrineapprovedunknownsubstrateinhibitorDetails
DB01238Aripiprazoleapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB01403MethotrimeprazineapprovedunknownsubstrateinhibitorDetails
DB01551Dihydrocodeineapproved, illicitunknownsubstrateDetails
DB00377Palonosetronapproved, investigationalunknownsubstrateDetails
DB04861Nebivololapproved, investigationalunknownsubstrateDetails
DB04889BicifadineinvestigationalunknownDetails
DB015621-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidineexperimental, illicitunknownDetails
DB06144Sertindoleapproved, investigational, withdrawnunknownsubstrateDetails
DB06148Mianserinapproved, investigationalunknownsubstrateinhibitorDetails
DB04905TesmilifeneinvestigationalunknownsubstrateDetails
DB01624Zuclopenthixolapproved, investigationalunknownsubstrateDetails
DB01576Dextroamphetamineapproved, illicitunknownsubstrateinhibitorDetails
DB00571Propranololapproved, investigationalunknownsubstrateinhibitorDetails
DB01186Pergolideapproved, investigational, vet_approved, withdrawnunknowninhibitorDetails
DB05271RotigotineapprovedunknownsubstrateinhibitorDetails
DB00268Ropiniroleapproved, investigationalunknowninhibitorDetails
DB00589Lisurideapproved, investigationalunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01095FluvastatinapprovedunknownsubstrateinhibitorDetails
DB01076AtorvastatinapprovedunknowninhibitorDetails
DB00439CerivastatinwithdrawnunknowninhibitorDetails
DB00619ImatinibapprovedunknownsubstrateinhibitorDetails
DB00334Olanzapineapproved, investigationalunknownsubstrateinhibitorDetails
DB00792Tripelennamineapproved, vet_approvedunknowninhibitorDetails
DB00188Bortezomibapproved, investigationalunknownsubstrateinhibitorDetails
DB05109Trabectedinapproved, investigationalunknownsubstrateDetails
DB00568Cinnarizineapproved, investigationalunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB06726Bufuralolexperimental, investigationalunknownsubstrateDetails
DB014724-Methoxyamphetamineexperimental, illicitunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB06727SparteineexperimentalunknownsubstrateinhibitorDetails
DB00283ClemastineapprovedunknowninhibitorDetails
DB00907Cocaineapproved, illicitunknowninhibitorDetails
DB00997Doxorubicinapproved, investigationalunknownsubstrateinhibitorDetails
DB00333MethadoneapprovedunknownsubstrateinhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB00211MidodrineapprovedunknowninhibitorDetails
DB00208TiclopidineapprovedunknownsubstrateinhibitorDetails
DB00543AmoxapineapprovedunknownsubstrateDetails
DB00608Chloroquineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB04946IloperidoneapprovedunknownsubstrateDetails
DB01577Methamphetamineapproved, illicitunknownsubstrateinhibitorDetails
DB01621Pipotiazineapproved, investigationalunknownsubstrateinhibitorDetails
DB00344ProtriptylineapprovedunknownsubstrateDetails
DB00706Tamsulosinapproved, investigationalunknownsubstrateDetails
DB04844TetrabenazineapprovedunknownsubstrateDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB00932Tipranavirapproved, investigationalunknownsubstrateinhibitorDetails
DB04855DronedaroneapprovedunknownsubstrateinhibitorDetails
DB00951IsoniazidapprovedunknowninhibitorDetails
DB06708LumefantrineapprovedunknowninhibitorDetails
DB04868Nilotinibapproved, investigationalunknowninhibitorDetails
DB00205Pyrimethamineapproved, vet_approvedunknowninhibitorDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00238NevirapineapprovedunknownsubstrateinhibitorDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB01628Etoricoxibapproved, investigationalunknownsubstrateinhibitorDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateinhibitorDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB00924CyclobenzaprineapprovedunknownsubstrateDetails
DB03128AcetylcholineapprovedunknownsubstrateDetails
DB01426Ajmalineapproved, investigationalunknownsubstrateinhibitorDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB00701AmprenavirapprovedunknownsubstrateDetails
DB00276AmsacrineapprovedunknownsubstrateDetails
DB01429AprindineapprovedunknownsubstrateDetails
DB06697ArtemetherapprovedunknownsubstrateinhibitorDetails
DB00637Astemizoleapproved, withdrawnunknownsubstrateDetails
DB00245BenzatropineapprovedunknownsubstrateDetails
DB01244Bepridilapproved, withdrawnunknownsubstrateDetails
DB00195BetaxololapprovedunknownsubstrateinhibitorDetails
DB00810Biperidenapproved, investigationalunknowninhibitorDetails
DB00835BrompheniramineapprovedunknownsubstrateinhibitorDetails
DB00297Bupivacaineapproved, investigationalunknownsubstrateDetails
DB00490Buspironeapproved, investigationalunknownsubstrateDetails
DB00201CaffeineapprovedunknownsubstrateDetails
DB00748CarbinoxamineapprovedunknowninhibitorDetails
DB00567Cephalexinapproved, vet_approvedunknownsubstrateDetails
DB00475Chlordiazepoxideapproved, illicitunknownsubstrateDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00604Cisaprideapproved, investigational, withdrawnunknowninhibitorDetails
DB00169Cholecalciferolapproved, nutraceuticalunknowninhibitorDetails
DB00531Cyclophosphamideapproved, investigationalunknownsubstrateDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknowninducerDetails
DB01093Dimethyl sulfoxideapproved, vet_approvedunknowninhibitorDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00988DopamineapprovedunknownsubstrateDetails
DB00590DoxazosinapprovedunknownsubstrateDetails
DB00625Efavirenzapproved, investigationalunknowninhibitorDetails
DB00751Epinastineapproved, investigationalunknownsubstrateinhibitorDetails
DB01023Felodipineapproved, investigationalunknowninhibitorDetails
DB00950FexofenadineapprovedunknowninhibitorDetails
DB00889Granisetronapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB01159Halothaneapproved, vet_approvedunknownsubstrateDetails
DB05381Histamineapproved, investigationalunknowninhibitorDetails
DB01005HydroxyureaapprovedunknowninhibitorDetails
DB01611HydroxychloroquineapprovedunknowninhibitorDetails
DB01177IdarubicinapprovedunknownsubstrateinhibitorDetails
DB00224IndinavirapprovedunknowninhibitorDetails
DB01029Irbesartanapproved, investigationalunknowninhibitorDetails
DB00598LabetalolapprovedunknownsubstrateinhibitorDetails
DB00448Lansoprazoleapproved, investigationalunknowninhibitorDetails
DB00528Lercanidipineapproved, investigationalunknowninhibitorDetails
DB01235LevodopaapprovedunknownsubstrateDetails
DB01206LomustineapprovedunknownsubstrateinhibitorDetails
DB00227Lovastatinapproved, investigationalunknowninhibitorDetails
DB00358MefloquineapprovedunknowninhibitorDetails
DB06691Mepyramineapproved, vet_approvedunknowninhibitorDetails
DB00703MethazolamideapprovedunknowninhibitorDetails
DB01028Methoxyfluraneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00422Methylphenidateapproved, investigationalunknownsubstrateinhibitorDetails
DB01107Methyprylonapproved, illicit, withdrawnunknownsubstrateDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorDetails
DB00731Nateglinideapproved, investigationalunknownsubstrateDetails
DB00220NelfinavirapprovedunknowninhibitorDetails
DB02701NicotinamideapprovedunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateDetails
DB00627Niacinapproved, investigational, nutraceuticalunknowninhibitorDetails
DB00336Nitrofuralapproved, investigational, vet_approvedunknownsubstrateDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01096OxamniquineapprovedunknowninhibitorDetails
DB01580OxprenololapprovedunknowninhibitorDetails
DB01062Oxybutyninapproved, investigationalunknowninhibitorDetails
DB00738PentamidineapprovedunknownsubstrateinhibitorDetails
DB01435AntipyrineapprovedunknownsubstrateinhibitorDetails
DB00191Phentermineapproved, illicitunknowninhibitorDetails
DB01100PimozideapprovedunknowninhibitorDetails
DB01132Pioglitazoneapproved, investigationalunknowninhibitorDetails
DB00592Piperazineapproved, vet_approvedunknownsubstrateDetails
DB00175PravastatinapprovedunknowninhibitorDetails
DB01058Praziquantelapproved, vet_approvedunknowninhibitorDetails
DB01087PrimaquineapprovedunknowninhibitorDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateDetails
DB00818Propofolapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00852PseudoephedrineapprovedunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateinhibitorDetails
DB00409Remoxiprideapproved, withdrawnunknownsubstrateDetails
DB01201RifapentineapprovedunknowninducerDetails
DB00989Rivastigmineapproved, investigationalunknowninhibitorDetails
DB00296RopivacaineapprovedunknownsubstrateDetails
DB00412Rosiglitazoneapproved, investigationalunknowninhibitorDetails
DB01698Rutinexperimental, investigationalunknowninhibitorDetails
DB01232Saquinavirapproved, investigationalunknownsubstrateinhibitorDetails
DB01037Selegilineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00641SimvastatinapprovedunknownsubstrateinhibitorDetails
DB00259SulfanilamideapprovedunknowninhibitorDetails
DB06729SulfaphenazoleapprovedunknowninhibitorDetails
DB01079Tegaserodinvestigational, withdrawnunknownsubstrateinhibitorDetails
DB00976TelithromycinapprovedunknowninhibitorDetails
DB00277TheophyllineapprovedunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB01623ThiothixeneapprovedunknowninhibitorDetails
DB00427TriprolidineapprovedunknowninhibitorDetails
DB00209TrospiumapprovedunknowninhibitorDetails
DB00661VerapamilapprovedunknowninhibitorDetails
DB00570VinblastineapprovedunknownsubstrateinhibitorDetails
DB00361Vinorelbineapproved, investigationalunknownsubstrateinhibitorDetails
DB01392Yohimbineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00549Zafirlukastapproved, investigationalunknowninhibitorDetails
DB00943Zalcitabineapproved, investigationalunknownsubstrateDetails
DB00246ZiprasidoneapprovedunknowninhibitorDetails
DB06287TemsirolimusapprovedunknowninhibitorDetails
DB01437Glutethimideapproved, illicitunknowninducerDetails
DB06701DexmethylphenidateapprovedunknownsubstrateinhibitorDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB01128BicalutamideapprovedunknowninhibitorDetails
DB01129Rabeprazoleapproved, investigationalunknowninhibitorDetails
DB01166CilostazolapprovedunknownsubstrateDetails
DB06216AsenapineapprovedunknowninhibitorDetails
DB06589PazopanibapprovedunknownsubstrateinhibitorDetails
DB06702FesoterodineapprovedunknownsubstrateDetails
DB06684VilazodoneapprovedunknownsubstrateinhibitorDetails
DB00836LoperamideapprovedunknownsubstrateDetails
DB01267PaliperidoneapprovedunknownDetails
DB06770Benzyl alcoholapprovedunknownsubstrateDetails
DB04920ClevidipineapprovedunknownsubstrateDetails
DB00633Dexmedetomidineapproved, vet_approvedunknowninhibitorDetails
DB06735EnclomipheneinvestigationalunknownsubstrateDetails
DB06204TapentadolapprovedunknownsubstrateinhibitorDetails
DB08868Fingolimodapproved, investigationalunknownsubstrateDetails
DB04871LorcaserinapprovednosubstrateinhibitorDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB08881VemurafenibapprovedunknowninhibitorDetails
DB08893MirabegronapprovedunknownsubstrateinhibitorDetails
DB08899EnzalutamideapprovedunknowninhibitorDetails
DB08901PonatinibapprovedunknownsubstrateDetails
DB06800MethylnaltrexoneapprovedunknowninhibitorDetails
DB06203AlogliptinapprovedunknownsubstrateDetails
DB08918LevomilnacipranapprovedunknownsubstrateDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB09039EliglustatapprovedunknownsubstrateinhibitorDetails
DB09048NetupitantapprovedyessubstrateDetails
DB09049NaloxegolapprovedunknowninhibitorDetails
DB09053IbrutinibapprovedunknownsubstrateDetails
DB09076UmeclidiniumapprovednosubstrateDetails
DB09065CobicistatapprovednoinhibitorDetails
DB09068VortioxetineapprovednosubstrateDetails
DB06016CariprazineapprovedunknownsubstrateDetails
DB00349Clobazamapproved, illicitunknowninhibitorDetails
DB09128BrexpiprazoleapprovednosubstrateDetails
DB09291RolapitantapprovednoinhibitorDetails
DB06678EsmirtazapineinvestigationalunknownsubstrateDetails
DB06603Panobinostatapproved, investigationalyesinhibitorDetails
DB09570IxazomibapprovedunknownsubstrateDetails
DB06412Oxymetholoneapproved, illicitunknowninhibitorDetails
DB09183DasabuvirapprovednosubstrateDetails
DB06512DeramciclaneinvestigationalunknowninhibitorDetails
DB00022Peginterferon alfa-2bapprovedunknowninhibitorDetails
DB00494Entacaponeapproved, investigationalunknowninhibitorDetails
DB00553MethoxsalenapprovedunknowninhibitorDetails
DB00822DisulfiramapprovedunknowninhibitorDetails
DB01007TioconazoleapprovedunknowninhibitorDetails
DB04839Cyproterone acetateapproved, investigationalunknowninhibitorDetails
DB04938OspemifeneapprovedunknowninhibitorDetails
DB06819Phenylbutyric acidapproved, investigationalunknowninhibitorDetails
DB06820SulconazoleapprovedunknowninhibitorDetails
DB08816TicagrelorapprovedunknowninhibitorDetails
DB08909Glycerol PhenylbutyrateapprovedunknowninhibitorDetails
DB00420Promazineapproved, vet_approvedunknowninhibitorDetails
DB09118StiripentolapprovedunknowninhibitorDetails
DB12332Rucaparibapproved, investigationalyessubstrateinhibitorDetails
DB09396Propoxyphene napsylateapprovedunknowninhibitorDetails
DB13139LevosalbutamolapprovedunknowninhibitorDetails
DB09555Dexchlorpheniramine maleateapprovednosubstrateDetails
DB12161Deutetrabenazineapproved, investigationalyessubstrateDetails
DB06217Vernakalantapproved, investigationalunknownsubstrateinhibitorDetails
DB06595MidostaurinapprovedunknowninhibitorDetails
DB11915Valbenazineapproved, investigationalnosubstrateDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB08922PerospironeapprovedunknownsubstrateDetails
DB09120ZucapsaicinapprovedunknowninhibitorDetails
DB09167DosulepinapprovedunknowninhibitorDetails
DB11614RupatadineapprovednosubstrateDetails
DB09238Manidipineapproved, investigationalunknowninhibitorDetails
DB13874EnasidenibapprovedunknownsubstrateinhibitorDetails
DB12070LetermovirapprovednosubstrateDetails