Glucose-6-phosphate 1-dehydrogenase

Details

Name
Glucose-6-phosphate 1-dehydrogenase
Synonyms
  • 1.1.1.49
  • G6PD
Gene Name
zwf
Organism
Leuconostoc mesenteroides
Amino acid sequence
>lcl|BSEQ0022275|Glucose-6-phosphate 1-dehydrogenase
MVSEIKTLVTFFGGTGDLAKRKLYPSVFNLYKKGYLQKHFAIVGTARQALNDDEFKQLVR
DSIKDFTDDQAQAEAFIEHFSYRAHDVTDAASYAVLKEAIEEAADKFDIDGNRIFYMSVA
PRFFGTIAKYLKSEGLLADTGYNRLMIEKPFGTSYDTAAELQNDLENAFDDNQLFRIDHY
LGKEMVQNIAALRFGNPIFDAAWNKDYIKNVQVTLSEVLGVEERAGYYDTAGALLDMIQN
HTMQIVGWLAMEKPESFTDKDIRAAKNAAFNALKIYDEAEVNKYFVRAQYGAGDSADFKP
YLEELDVPADSKNNTFIAGELQFDLPRWEGVPFYVRSGKRLAAKQTRVDIVFKAGTFNFG
SEQEAQEAVLSIIIDPKGAIELKLNAKSVEDAFNTRTIDLGWTVSDEDKKNTPEPYERMI
HDTMNGDGSNFADWNGVSIAWKFVDAISAVYTADKAPLETYKSGSMGPEASDKLLAANGD
AWVFKG
Number of residues
486
Molecular Weight
54440.585
Theoretical pI
4.57
GO Classification
Functions
glucose-6-phosphate dehydrogenase activity / NADP binding
Processes
glucose metabolic process / pentose-phosphate shunt
General Function
Nadp binding
Specific Function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Can utilize either NADP(+) or NAD(+).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0002855|1461 bp
ATGGTTTCAGAAATCAAGACGTTAGTAACTTTCTTTGGTGGCACTGGTGACTTGGCCAAG
CGTAAGCTTTACCCATCAGTTTTCAATCTTTATAAAAAAGGCTACTTGCAAAAGCATTTT
GCCATTGTTGGAACGGCCCGTCAAGCCCTCAATGATGACGAATTCAAACAATTGGTTCGT
GATTCAATTAAAGATTTCACTGACGATCAAGCACAAGCTGAGGCGTTCATCGAACATTTC
TCATACCGTGCACACGACGTAACAGATGCTGCTTCATACGCTGTTTTAAAAGAGGCGATT
GAAGAAGCTGCCGACAAATTTGATATCGATGGCAACCGCATTTTCTATATGTCAGTTGCG
CCACGTTTCTTTGGTACAATTGCCAAATATCTTAAGTCAGAAGGCCTACTAGCTGACACT
GGTTACAACCGTTTGATGATTGAAAAGCCTTTCGGTACATCATATGACACAGCTGCCGAA
CTCCAAAATGACTTGGAAAACGCATTTGATGATAACCAACTATTCCGTATTGACCACTAC
CTTGGTAAGGAAATGGTTCAAAACATTGCTGCCCTTCGCTTTGGTAACCCAATTTTCGAT
GCTGCTTGGAACAAGGATTACATCAAGAACGTTCAAGTAACATTGTCAGAAGTCTTGGGT
GTCGAAGAACGTGCCGGCTACTATGACACAGCCGGTGCATTGCTTGACATGATTCAAAAC
CACACCATGCAAATTGTTGGTTGGTTAGCCATGGAAAAACCAGAATCATTCACTGACAAA
GACATTCGTGCCGCTAAAAACGCAGCCTTTAATGCTTTGAAGATCTATGATGAAGCAGAA
GTTAACAAATACTTTGTTCGTGCACAATATGGTGCCGGTGATTCAGCTGACTTCAAGCCA
TACCTTGAAGAATTAGACGTACCTGCTGATTCTAAAAACAATACCTTCATCGCCGGCGAA
TTGCAATTTGATTTGCCACGTTGGGAGGGTGTCCCATTCTATGTCCGTTCAGGTAAGCGC
TTAGCTGCTAAACAGACACGGGTTGATATCGTCTTTAAGGCTGGCACGTTTAACTTTGGT
TCAGAACAAGAAGCACAAGAAGCTGTCTTGTCAATTATCATTGATCCAAAGGGTGCTATC
GAATTGAAGTTGAACGCCAAGTCAGTTGAAGATGCTTTCAACACACGTACAATTGACTTA
GGTTGGACTGTATCTGACGAAGATAAGAAGAACACGCCAGAACCATACGAACGTATGATT
CACGACACTATGAATGGTGATGGCTCTAACTTCGCTGACTGGAATGGCGTTTCAATCGCT
TGGAAGTTCGTTGATGCTATTTCAGCCGTTTATACCGCAGATAAAGCACCACTTGAAACT
TACAAGTCGGGCTCAATGGGTCCTGAAGCATCCGATAAATTATTGGCTGCCAATGGTGAT
GCTTGGGTGTTTAAAGGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP11411
UniProtKB Entry NameG6PD_LEUME
GenBank Protein ID149631
GenBank Gene IDM64446
General References
  1. Lee WT, Flynn TG, Lyons C, Levy HR: Cloning of the gene and amino acid sequence for glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. J Biol Chem. 1991 Jul 15;266(20):13028-34. [Article]
  2. Bhadbhade MM, Adams MJ, Flynn TG, Levy HR: Sequence identity between a lysine-containing peptide from Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase and an active site peptide from human erythrocyte glucose-6-phosphate dehydrogenase. FEBS Lett. 1987 Jan 26;211(2):243-6. [Article]
  3. Olive C, Geroch ME, Levy HR: Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies. J Biol Chem. 1971 Apr 10;246(7):2047-57. [Article]
  4. Lee WT, Levy HR: Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction. Protein Sci. 1992 Mar;1(3):329-34. [Article]
  5. Vought V, Ciccone T, Davino MH, Fairbairn L, Lin Y, Cosgrove MS, Adams MJ, Levy HR: Delineation of the roles of amino acids involved in the catalytic functions of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase. Biochemistry. 2000 Dec 12;39(49):15012-21. [Article]
  6. Rowland P, Basak AK, Gover S, Levy HR, Adams MJ: The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution. Structure. 1994 Nov 15;2(11):1073-87. [Article]
  7. Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR: On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase. Biochemistry. 1998 Mar 3;37(9):2759-67. [Article]
  8. Cosgrove MS, Gover S, Naylor CE, Vandeputte-Rutten L, Adams MJ, Levy HR: An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme. Biochemistry. 2000 Dec 12;39(49):15002-11. [Article]
  9. Naylor CE, Gover S, Basak AK, Cosgrove MS, Levy HR, Adams MJ: NADP+ and NAD+ binding to the dual coenzyme specific enzyme Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: different interdomain hinge angles are seen in different binary and ternary complexes. Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):635-48. Epub 2001 Apr 24. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02338NADPHexperimentalunknownDetails
DB03461Nicotinamide adenine dinucleotide phosphateexperimentalunknownDetails
DB04122beta-D-glucose 6-phosphateexperimentalunknownDetails