Cytochrome P450 2C9

Details

Name
Cytochrome P450 2C9
Synonyms
  • (R)-limonene 6-monooxygenase
  • (S)-limonene 6-monooxygenase
  • (S)-limonene 7-monooxygenase
  • 1.14.13.-
  • Cholesterol 25-hydroxylase
  • CYP2C10
  • CYPIIC9
  • Cytochrome P-450MP
  • Cytochrome P450 MP-4
  • Cytochrome P450 MP-8
  • Cytochrome P450 PB-1
  • S-mephenytoin 4-hydroxylase
Gene Name
CYP2C9
Organism
Human
Amino acid sequence
>lcl|BSEQ0005471|Cytochrome P450 2C9
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
Number of residues
490
Molecular Weight
55627.365
Theoretical pI
7.99
GO Classification
Functions
drug binding / oxidoreductase activity / iron ion binding / heme binding / arachidonic acid epoxygenase activity / monooxygenase activity / steroid hydroxylase activity / (R)-limonene 6-monooxygenase activity / oxygen binding / (S)-limonene 6-monooxygenase activity / aromatase activity / (S)-limonene 7-monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / caffeine oxidase activity
Processes
drug catabolic process / oxidation-reduction process / monoterpenoid metabolic process / steroid metabolic process / omega-hydroxylase P450 pathway / xenobiotic metabolic process / oxidative demethylation / arachidonic acid metabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / monocarboxylic acid metabolic process / cellular amide metabolic process / small molecule metabolic process / urea metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016893|Cytochrome P450 2C9 (CYP2C9)
ATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCACTCTGG
AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA
AATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAATCTCTCAAAGGTC
TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATAT
GAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTC
CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG
GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC
ATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAG
TTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCT
CCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATG
AAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCT
CAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCT
GAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAG
ACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAA
GACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGAC
CTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTC
ATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAA
TTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAG
AAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG
GCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCT
CTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCG
CCCTTCTACCAGCTGTGCTTCATTCCTGTCTGA
Chromosome Location
10
Locus
10q24
External Identifiers
ResourceLink
UniProtKB IDP11712
UniProtKB Entry NameCP2C9_HUMAN
GenBank Gene IDAY341248
GenAtlas IDCYP2C9
HGNC IDHGNC:2623
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB025074-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-OneexperimentalunknownDetails
DB03317Heme CexperimentalunknownDetails
DB00196Fluconazoleapproved, investigationalunknowninhibitorDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateinhibitorDetails
DB00222GlimepirideapprovedunknownsubstrateDetails
DB00250Dapsoneapproved, investigationalunknownsubstrateinducerDetails
DB00327Hydromorphoneapproved, illicitunknownsubstrateDetails
DB00469TenoxicamapprovedunknownsubstrateDetails
DB00470Dronabinolapproved, illicitunknownsubstrateDetails
DB00471MontelukastapprovedunknownsubstrateDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateDetails
DB00549Zafirlukastapproved, investigationalunknownsubstrateinhibitorDetails
DB00559Bosentanapproved, investigationalunknownsubstrateinducerDetails
DB00580Valdecoxibapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00582Voriconazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateDetails
DB00617ParamethadioneapprovedunknownsubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorDetails
DB00678LosartanapprovedunknownsubstrateDetails
DB00682WarfarinapprovedunknownsubstrateDetails
DB00712Flurbiprofenapproved, investigationalunknownsubstrateDetails
DB00731Nateglinideapproved, investigationalunknownsubstrateDetails
DB00744Zileutonapproved, investigational, withdrawnunknownsubstrateDetails
DB00749Etodolacapproved, investigational, vet_approvedunknownsubstrateDetails
DB00784Mefenamic acidapprovedunknownsubstrateDetails
DB00814Meloxicamapproved, vet_approvedunknownsubstrateDetails
DB00870Suprofenapproved, withdrawnunknownsubstrateinhibitorDetails
DB00916MetronidazoleapprovedunknowninhibitorDetails
DB00946Phenprocoumonapproved, investigationalunknownsubstrateDetails
DB00983Formoterolapproved, investigationalunknownsubstrateDetails
DB01015SulfamethoxazoleapprovedunknownsubstrateinhibitorDetails
DB01029Irbesartanapproved, investigationalunknownsubstrateDetails
DB01050IbuprofenapprovedunknownsubstrateDetails
DB01067Glipizideapproved, investigationalunknownsubstrateDetails
DB01095FluvastatinapprovedunknownsubstrateinhibitorDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB01136Carvedilolapproved, investigationalunknownsubstrateDetails
DB01283Lumiracoxibapproved, investigationalunknownsubstrateDetails
DB00969Alosetronapproved, withdrawnunknownsubstrateDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00214TorasemideapprovedunknownsubstrateDetails
DB00252Phenytoinapproved, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00412Rosiglitazoneapproved, investigationalunknownsubstrateDetails
DB00448Lansoprazoleapproved, investigationalunknowninhibitorinducerDetails
DB00503Ritonavirapproved, investigationalunknowninducerDetails
DB00532Mephenytoinapproved, investigational, withdrawnunknownsubstrateDetails
DB00673Aprepitantapproved, investigationalunknowninducerDetails
DB00705DelavirdineapprovedunknowninhibitorDetails
DB00967Desloratadineapproved, investigationalunknownDetails
DB01016GlyburideapprovedunknownsubstrateinhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB01118Amiodaroneapproved, investigationalunknowninhibitorDetails
DB01124Tolbutamideapproved, investigationalunknownsubstrateDetails
DB01241GemfibrozilapprovedunknowninhibitorDetails
DB13179TroleandomycinapprovedunknownDetails
DB01381Ginkgo bilobaapproved, investigational, nutraceuticalunknowninhibitorDetails
DB01418Acenocoumarolapproved, investigationalunknownsubstrateDetails
DB025074-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-OneexperimentalunknownDetails
DB04856DexloxiglumideinvestigationalunknownDetails
DB06442AvasimibeinvestigationalunknowninhibitorDetails
DB01098RosuvastatinapprovedunknownsubstrateDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownsubstrateDetails
DB00796Candesartan cilexetilapprovedunknownsubstrateDetails
DB00227Lovastatinapproved, investigationalunknowninhibitorDetails
DB00641SimvastatinapprovedunknowninhibitorDetails
DB01076AtorvastatinapprovedunknowninhibitorDetails
DB00439Cerivastatinapproved, withdrawnunknowninhibitorDetails
DB01072Atazanavirapproved, investigationalunknownsubstrateDetails
DB01181IfosfamideapprovedunknownsubstrateDetails
DB00619ImatinibapprovedunknownsubstrateinhibitorDetails
DB00468QuinineapprovedunknownsubstrateDetails
DB01142Doxepinapproved, investigationalunknownsubstrateDetails
DB00321AmitriptylineapprovedunknownsubstrateDetails
DB04557Arachidonic AcidexperimentalunknownsubstrateDetails
DB01045RifampicinapprovedunknowninducerDetails
DB01174Phenobarbitalapproved, investigationalunknownsubstrateinducerDetails
DB00404Alprazolamapproved, illicit, investigationalunknownsubstrateDetails
DB00363ClozapineapprovedunknownsubstrateDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB01357MestranolapprovedunknownsubstrateDetails
DB00788Naproxenapproved, vet_approvedunknownsubstrateDetails
DB00531Cyclophosphamideapproved, investigationalunknownsubstrateDetails
DB01355HexobarbitalexperimentalunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateDetails
DB00554Piroxicamapproved, investigationalunknownsubstrateDetails
DB00208TiclopidineapprovedunknowninhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB01435Antipyrineapproved, investigationalunknownsubstrateDetails
DB00177Valsartanapproved, investigationalunknownsubstrateinhibitorDetails
DB00188Bortezomibapproved, investigationalnosubstrateinhibitorDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownsubstrateDetails
DB05109Trabectedinapproved, investigationalunknownsubstrateDetails
DB00285VenlafaxineapprovedunknownsubstrateDetails
DB00313Valproic Acidapproved, investigationalunknownsubstrateinhibitorDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00238NevirapineapprovedunknownDetails
DB06652VicrivirocinvestigationalunknownsubstrateDetails
DB00972AzelastineapprovedunknownsubstrateinhibitorDetails
DB00568Cinnarizineapproved, investigationalunknownsubstrateDetails
DB04841FlunarizineapprovedunknownsubstrateDetails
DB01075Diphenhydramineapproved, investigationalunknownsubstrateDetails
DB06725Lornoxicamapproved, investigationalunknownsubstrateDetails
DB01039FenofibrateapprovedunknowninhibitorDetails
DB00951Isoniazidapproved, investigationalunknowninhibitorDetails
DB00812Phenylbutazoneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB06729SulfaphenazoleapprovedunknowninhibitorDetails
DB00444TeniposideapprovedunknowninhibitorDetails
DB06414EtravirineapprovedunknownsubstrateinhibitorinducerDetails
DB01320Fosphenytoinapproved, investigationalunknownsubstrateinducerDetails
DB01221Ketamineapproved, vet_approvedunknownsubstrateinducerDetails
DB00359Sulfadiazineapproved, investigational, vet_approvedunknowninhibitorDetails
DB01138SulfinpyrazoneapprovedunknownsubstrateinhibitorDetails
DB00263Sulfisoxazoleapproved, vet_approvedunknowninhibitorDetails
DB01198ZopicloneapprovedunknownsubstrateDetails
DB00564Carbamazepineapproved, investigationalunknowninducerDetails
DB00794Primidoneapproved, vet_approvedunknownsubstrateinducerDetails
DB01201Rifapentineapproved, investigationalunknowninducerDetails
DB00418Secobarbitalapproved, vet_approvedunknowninducerDetails
DB00625Efavirenzapproved, investigationalunknowninhibitorDetails
DB01097Leflunomideapproved, investigationalunknownsubstrateinhibitorDetails
DB04868Nilotinibapproved, investigationalunknowninhibitorDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB01101Capecitabineapproved, investigationalunknowninhibitorDetails
DB00544FluorouracilapprovedunknowninhibitorDetails
DB06268Sitaxentanapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00752Tranylcypromineapproved, investigationalunknowninhibitorDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB00758ClopidogrelapprovedunknownsubstrateinhibitorDetails
DB00843DonepezilapprovedunknownsubstrateDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB01036Tolterodineapproved, investigationalunknownsubstrateDetails
DB00328Indomethacinapproved, investigationalunknownsubstrateDetails
DB00936Salicylic acidapproved, investigational, vet_approvedunknownsubstrateDetails
DB01628Etoricoxibapproved, investigationalunknownsubstrateinhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB00818Propofolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00672Chlorpropamideapproved, investigationalunknownsubstrateDetails
DB01120GliclazideapprovedunknownsubstrateDetails
DB00201CaffeineapprovedunknownsubstrateDetails
DB00514DextromethorphanapprovedunknownsubstrateDetails
DB01009Ketoprofenapproved, vet_approvedunknownsubstrateinhibitorDetails
DB04725LicofeloneinvestigationalunknownsubstrateDetails
DB06737ZaltoprofenexperimentalunknownsubstrateDetails
DB06739SeratrodastexperimentalunknownsubstrateDetails
DB06738KetobemidoneexperimentalunknownsubstrateDetails
DB06736Aceclofenacapproved, investigationalunknownsubstrateDetails
DB00402Eszopicloneapproved, investigationalunknownsubstrateDetails
DB08798SulfamoxoleexperimentalunknowninhibitorDetails
DB06697ArtemetherapprovedunknownsubstrateDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknownsubstrateDetails
DB00381AmlodipineapprovedunknowninhibitorDetails
DB00613Amodiaquineapproved, investigationalunknowninhibitorDetails
DB00701Amprenavirapproved, investigationalunknownsubstrateDetails
DB01217Anastrozoleapproved, investigationalunknowninhibitorDetails
DB01117AtovaquoneapprovedunknowninhibitorDetails
DB00307Bexaroteneapproved, investigationalunknownsubstrateDetails
DB01156BupropionapprovedunknownsubstrateDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB00604Cisaprideapproved, investigational, withdrawnunknownsubstrateDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorDetails
DB01176CyclizineapprovedunknowninhibitorDetails
DB00266DicoumarolapprovedunknownsubstrateDetails
DB00757Dolasetronapproved, investigationalunknownsubstrateDetails
DB00869DorzolamideapprovedunknownsubstrateDetails
DB00668Epinephrineapproved, vet_approvedunknowninhibitorDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00655EstroneapprovedunknownsubstrateDetails
DB00898EthanolapprovedunknowninhibitorDetails
DB01023Felodipineapproved, investigationalunknowninhibitorDetails
DB01195Flecainideapproved, withdrawnunknowninhibitorDetails
DB01544Flunitrazepamapproved, illicitunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB01159Halothaneapproved, vet_approvedunknownsubstrateDetails
DB05381Histamineapproved, investigationalunknownsubstrateDetails
DB01177IdarubicinapprovedunknownsubstrateDetails
DB00281Lidocaineapproved, vet_approvedunknownsubstrateDetails
DB01601LopinavirapprovedunknowninhibitorinducerDetails
DB00603Medroxyprogesterone acetateapproved, investigationalunknowninhibitorDetails
DB00333MethadoneapprovedunknownsubstrateDetails
DB01028Methoxyfluraneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00370MirtazapineapprovedunknownsubstrateDetails
DB01171Moclobemideapproved, investigationalunknownsubstrateDetails
DB00745Modafinilapproved, investigationalunknowninhibitorinducerDetails
DB00184NicotineapprovedunknownsubstrateDetails
DB00904OndansetronapprovedunknownsubstrateDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB01132Pioglitazoneapproved, investigationalunknownsubstrateDetails
DB01411PranlukastinvestigationalunknowninhibitorDetails
DB01131ProguanilapprovedunknownsubstrateDetails
DB01069Promethazineapproved, investigationalunknowninhibitorDetails
DB01589Quazepamapproved, illicitunknownsubstrateDetails
DB00908Quinidineapproved, investigationalunknownsubstrateinhibitorDetails
DB00533Rofecoxibapproved, investigational, withdrawnunknownsubstrateDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateDetails
DB06150Sulfadimethoxineapproved, vet_approvedunknowninhibitorDetails
DB00576Sulfamethizoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00891SulfapyridineapprovedunknowninhibitorDetails
DB00231Temazepamapproved, investigationalunknownsubstrateDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB00323Tolcaponeapproved, withdrawnnoinhibitorDetails
DB00347TrimethadioneapprovedunknownsubstrateDetails
DB00726TrimipramineapprovedunknownsubstrateDetails
DB00197Troglitazoneinvestigational, withdrawnunknownsubstrateinhibitorDetails
DB04898Ximelagatranapproved, investigational, withdrawnunknownsubstrateDetails
DB00495ZidovudineapprovedunknownsubstrateDetails
DB00755Tretinoinapproved, investigational, nutraceuticalunknownsubstrateDetails
DB01128BicalutamideapprovedunknowninhibitorDetails
DB01129Rabeprazoleapproved, investigationalunknowninhibitorDetails
DB01274Arformoterolapproved, investigationalunknownsubstrateDetails
DB04574Estrone sulfateapprovedunknownsubstrateinhibitorDetails
DB06413Armodafinilapproved, investigationalnoinhibitorDetails
DB00255Diethylstilbestrolapproved, investigationalunknowninhibitorDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateDetails
DB06594Agomelatineapproved, investigationalunknowninhibitorDetails
DB04831TicrynafenwithdrawnunknownDetails
DB06174NoscapineinvestigationalunknowninhibitorDetails
DB04920Clevidipineapproved, investigationalunknowninhibitorDetails
DB06370IndisulaminvestigationalunknownsubstrateDetails
DB06803Niclosamideapproved, investigational, vet_approvedunknownsubstrateDetails
DB00515CisplatinapprovedunknowninhibitorDetails
DB06820SulconazoleapprovedunknowninhibitorDetails
DB01154Thiamylalapproved, vet_approvedunknownsubstrateDetails
DB08828Vismodegibapproved, investigationalnosubstrateinhibitorDetails
DB00374Treprostinilapproved, investigationalunknownsubstrateDetails
DB06204TapentadolapprovedunknownsubstrateDetails
DB06209PrasugrelapprovedyessubstrateDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB08875Cabozantinibapproved, investigationalnosubstrateDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB08896RegorafenibapprovedunknowninhibitorDetails
DB08899EnzalutamideapprovedunknownsubstrateinducerDetails
DB04938Ospemifeneapproved, investigationalunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknowninhibitorDetails
DB06292DapagliflozinapprovednosubstrateDetails
DB09048Netupitantapproved, investigationalyessubstrateDetails
DB09080OlodaterolapprovednosubstrateDetails
DB09068Vortioxetineapproved, investigationalnosubstrateDetails
DB08439ParecoxibapprovedunknownsubstrateinhibitorDetails
DB09280LumacaftorapprovednoinhibitorinducerDetails
DB09570Ixazomibapproved, investigationalunknownsubstrateDetails
DB11560Lesinuradapproved, investigationalnosubstrateDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB08816TicagrelorapprovedunknowninhibitorDetails
DB09063CeritinibapprovedunknowninhibitorDetails
DB00322FloxuridineapprovedunknowninhibitorDetails
DB05219Crisaboroleapproved, investigationalnoinhibitorDetails
DB06595Midostaurinapproved, investigationalunknowninhibitorinducerDetails
DB05015Belinostatapproved, investigationalunknowninhibitorDetails
DB05541Brivaracetamapproved, investigationalnosubstrateDetails
DB11611LifitegrastapprovedunknowninhibitorDetails
DB13174RheinexperimentalunknowninhibitorDetails
DB11994Diacereinapproved, investigationalunknowninhibitorDetails
DB03756Doconexentapproved, investigationalunknownsubstrateinhibitorDetails
DB11943Delafloxacinapproved, investigationalunknowninducerDetails
DB01685TopiroxostatexperimentalunknowninhibitorDetails
DB09120Zucapsaicinapproved, investigationalunknowninhibitorDetails
DB09118StiripentolapprovedunknowninhibitorDetails
DB09198LobeglitazoneexperimentalnoinhibitorDetails
DB09167DosulepinapprovedunknowninhibitorDetails
DB11614RupatadineapprovednosubstrateDetails
DB12319Benzbromaroneinvestigational, withdrawnunknowninhibitorDetails
DB09238Manidipineapproved, investigationalunknowninhibitorDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB13919CandesartanexperimentalunknownsubstrateinhibitorDetails
DB12070Letermovirapproved, investigationalnoinducerDetails
DB12332Rucaparibapproved, investigationalunknowninhibitorDetails
DB09061Cannabidiolapproved, investigationalnosubstrateDetails
DB13943Testosterone cypionateapprovedunknownsubstrateDetails
DB13944Testosterone enanthateapprovedunknownsubstrateDetails
DB13946Testosterone undecanoateapproved, investigationalunknownsubstrateDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13941Piperaquineexperimental, investigationalunknownsubstrateDetails
DB11901Apalutamideapproved, investigationalunknowninducerDetails
DB11633Isavuconazoleapproved, investigationalunknowninhibitorinducerDetails
DB11586Asunaprevirapproved, investigational, withdrawnnosubstrateDetails
DB13975Cimicifuga racemosaapproved, experimentalnoinhibitorDetails
DB14011NabiximolsinvestigationalnosubstrateDetails
DB14009Medical Cannabisexperimental, investigationalnosubstrateinhibitorDetails
DB13746Bioallethrinapproved, experimentalnosubstrateDetails
DB00486Nabiloneapproved, investigationalnoinhibitorDetails
DB14033Acetyl sulfisoxazoleapproved, vet_approvedunknowninhibitorDetails
DB11995Avatrombopagapproved, investigationalunknowninducerDetails
DB11672Curcuminapproved, experimental, investigationalnoinhibitorDetails
DB00949FelbamateapprovedunknowninhibitorDetails
DB12582PiperineinvestigationalunknowninhibitorDetails
DB13136Fluindioneapproved, investigationalunknownsubstrateDetails
DB14568Ivosidenibapproved, investigationalunknowninducerDetails
DB12474Lynestrenolapproved, investigationalnosubstrateDetails
DB00615Rifabutinapproved, investigationalnoinducerDetails
DB11753RifamycininvestigationalnoinducerDetails
DB06654Safinamideapproved, investigationalunknowninhibitorDetails
DB04818IproniazidwithdrawnunknowninhibitorDetails
DB01645GenisteininvestigationalunknowninhibitorDetails
DB09078Lenvatinibapproved, investigationalunknowninhibitorDetails
DB08881VemurafenibapprovedunknowninhibitorDetails
DB00839Tolazamideapproved, investigationalunknownsubstrateDetails
DB00414Acetohexamideapproved, investigational, withdrawnunknownsubstrateDetails
DB01251Gliquidoneapproved, investigationalunknownsubstrateDetails
DB01289GlisoxepideinvestigationalunknownsubstrateDetails
DB08962Glibornurideinvestigational, withdrawnunknownsubstrateDetails
DB08496(R)-warfarinexperimentalunknownsubstrateDetails
DB14055(S)-Warfarinexperimental, investigationalunknownsubstrateDetails
DB00022Peginterferon alfa-2bapprovedunknowninducerDetails
DB04911Oritavancinapproved, investigationalunknowninhibitorDetails
DB06717FosaprepitantapprovedunknowninducerDetails
DB09288PropacetamolexperimentalnosubstrateDetails
DB14635Curcumin sulfateexperimentalnoDetails
DB01080VigabatrinapprovedunknowninducerDetails
DB06218LacosamideapprovednosubstrateDetails
DB09213Dexibuprofenapproved, investigationalunknownDetails
DB08912Dabrafenibapproved, investigationalnoinducerDetails
DB00834Mifepristoneapproved, investigationalnoinhibitorDetails
DB00980Ramelteonapproved, investigationalnosubstrateDetails
DB00440Trimethoprimapproved, vet_approvedunknownsubstrateDetails
DB04665CoumarinexperimentalnosubstrateDetails