Xylose isomerase

Details

Name
Xylose isomerase
Synonyms
  • 5.3.1.5
Gene Name
xylA
Organism
Arthrobacter sp. (strain NRRL B3728)
Amino acid sequence
>lcl|BSEQ0016355|Xylose isomerase
MSVQPTPADHFTFGLWTVGWTGADPFGVATRKNLDPVEAVHKLAELGAYGITFHDNDLIP
FDATEAEREKILGDFNQALKDTGLKVPMVTTNLFSHPVFKDGGFTSNDRSIRRFALAKVL
HNIDLAAEMGAETFVMWGGREGSEYDGSKDLAAALDRMREGVDTAAGYIKDKGYNLRIAL
EPKPNEPRGDIFLPTVGHGLAFIEQLEHGDIVGLNPETGHEQMAGLNFTHGIAQALWAEK
LFHIDLNGQRGIKYDQDLVFGHGDLTSAFFTVDLLENGFPNGGPKYTGPRHFDYKPSRTD
GYDGVWDSAKANMSMYLLLKERALAFRADPEVQEAMKTSGVFELGETTLNAGESAADLMN
DSASFAGFDAEAAAERNFAFIRLNQLAIEHLLGSR
Number of residues
395
Molecular Weight
43291.15
Theoretical pI
4.73
GO Classification
Functions
magnesium ion binding / xylose isomerase activity
Processes
D-xylose metabolic process / pentose-phosphate shunt
Components
cytoplasm
General Function
Xylose isomerase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0002428|1188 bp
ATGAGCGTTCAGCCGACCCCTGCAGACCACTTCACCTTTGGCCTCTGGACCGTAGGATGG
ACCGGCGCCGACCCATTCGGTGTCGCCACCCGCAAGAACCTGGACCCGGTAGAAGCCGTC
CACAAGCTGGCCGAGCTCGGCGCCTACGGCATCACCTTCCACGACAATGACCTGATTCCT
TTTGACGCCACCGAGGCAGAGCGCGAAAAGATCCTTGGTGACTTCAACCAGGCGCTGAAG
GACACCGGCCTGAAGGTCCCAATGGTGACCACCAACCTGTTCAGCCACCCGGTCTTCAAG
GACGGCGGCTTCACCTCTAACGACCGCTCGATCCGTCGTTTTGCACTGGCTAAGGTCCTG
CACAACATCGACTTGGCAGCCGAGATGGGCGCCGAAACCTTCGTCATGTGGGGCGGGCGC
GAAGGCAGCGAATACGACGGTTCCAAGGACCTGGCCGCAGCACTTGATCGCATGCGCGAA
GGCGTGGACACGGCAGCTGGCTACATCAAGGACAAGGGTTACAACCTGCGCATCGCGCTG
GAGCCAAAGCCAAATGAACCACGCGGCGACATCTTCCTGCCTACCGTCGGCCACGGCCTG
GCCTTCATCGAGCAGCTGGAGCACGGCGACATCGTCGGCCTGAACCCAGAAACCGGCCAC
GAGCAGATGGCCGGCCTGAACTTCACCCACGGCATCGCTCAGGCACTGTGGGCCGAGAAG
CTGTTCCACATTGACCTCAACGGCCAGCGCGGCATCAAGTACGACCAGGACCTGGTCTTC
GGCCACGGCGATCTGACCAGCGCGTTCTTCACCGTAGACCTGCTGGAAAACGGCTTCCCT
AACGGCGGACCAAAGTACACCGGCCCACGCCACTTCGACTACAAGCCATCGCGCACCGAC
GGCTACGACGGCGTGTGGGACTCGGCCAAGGCCAACATGTCCATGTACCTGCTGCTCAAG
GAACGTGCCCTGGCCTTCCGTGCGGATCCAGAGGTACAGGAAGCCATGAAGACCTCGGGC
GTCTTCGAACTGGGCGAAACCACCCTGAACGCCGGGGAAAGCGCAGCGGATCTGATGAAT
GATTCCGCGAGCTTCGCAGGCTTTGACGCCGAGGCCGCCGCAGAGCGCAACTTCGCGTTC
ATCCGCCTGAACCAGCTGGCCATCGAGCACCTGCTCGGCTCCCGCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP12070
UniProtKB Entry NameXYLA_ARTS7
GenBank Protein ID39059
GenBank Gene IDX59466
General References
  1. Loviny-Anderton T, Shaw PC, Shin MK, Hartley BS: D-Xylose (D-glucose) isomerase from Arthrobacter strain N.R.R.L. B3728. Gene cloning, sequence and expression. Biochem J. 1991 Jul 1;277 ( Pt 1):263-71. [Article]
  2. Smith CA, Rangarajan M, Hartley BS: D-Xylose (D-glucose) isomerase from Arthrobacter strain N.R.R.L. B3728. Purification and properties. Biochem J. 1991 Jul 1;277 ( Pt 1):255-61. [Article]
  3. Collyer CA, Henrick K, Blow DM: Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. J Mol Biol. 1990 Mar 5;212(1):211-35. [Article]
  4. Henrick K, Collyer CA, Blow DM: Structures of D-xylose isomerase from Arthrobacter strain B3728 containing the inhibitors xylitol and D-sorbitol at 2.5 A and 2.3 A resolution, respectively. J Mol Biol. 1989 Jul 5;208(1):129-57. [Article]
  5. Henrick K, Blow DM, Carrell HL, Glusker JP: Comparison of backbone structures of glucose isomerase from Streptomyces and Arthrobacter. Protein Eng. 1987 Dec;1(6):467-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11195Xylitolexperimental, investigationalunknownDetails
DB021722,5-Dideoxy-2,5-Imino-D-GlucitolexperimentalunknownDetails
DB03206DuvoglustatinvestigationalunknownDetails